A5000481939- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Software Engineering Research
- Toxoplasma gondii Research Studies
- interferon and immune responses
- Congenital Anomalies and Fetal Surgery
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Software Engineering Techniques and Practices
- Pregnancy and preeclampsia studies
- NF-κB Signaling Pathways
- Peroxisome Proliferator-Activated Receptors
- Cell death mechanisms and regulation
- Immune cells in cancer
- Data Quality and Management
Ningxia Center for Diseases Prevention and Control
2025
Dalian Medical University
2018-2024
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2024
Second Affiliated Hospital of Dalian Medical University
2018-2024
Shenzhen University
2022-2023
Ningxia Medical University
2016-2022
ORCID
2021-2022
Zhejiang Chinese Medical University
2022
Weatherford College
2021
Health Foundation
2021
Hypoxia‑induced apoptosis occurs in various diseases. Cobalt chloride (CoCl2) is a hypoxia mimic agent that frequently used studies investigating the mechanisms of hypoxia. Nuclear respiratory factor‑1 (NRF‑1) transcription factor with an important role expression mitochondrial and mitochondria‑associated genes. However, few have evaluated effects NRF‑1 on apoptosis, particularly regard to damage caused by CoCl2. In present study, mediating CoCl2‑induced was investigated using cell viability...
This study aimed to address inconsistencies in results between the H9C2 myocardial hypoxia (MH) cell line and infarction (MI) rat models used MI research. We identified differentially expressed genes (DEGs) underlying molecular mechanisms using RNA sequencing technology.
Cystic echinococcosis (CE) is a parasitic disease that caused by Echinococcus granulosus (Eg). The recombinant antigen P29 (rEg.P29) was shown to confer effective immunity sheep and mice during E. secondary infection in our previous study. In this study, we sought investigate the ability of long noncoding RNA 028466 (lncRNA028466) as regulator for protective mediated rEg.P29 vaccination study effects lncRNA028466 on CD4+T cell differentiation spleen.Female BALB/c were divided into two groups...
Background Recent studies have shown that long non-coding RNAs (lncRNAs) may play key regulatory roles in many malignant tumors. This study investigated the use of novel lncRNA biomarkers diagnosis and prognosis breast cancer. Materials Methods The database subsets Cancer Genome Atlas (TCGA) by RNA-seq for comparing analysis tissue samples between cancer normal control groups were downloaded. Additionally, anticoagulant peripheral blood collected used this cohort study. extracellular...
MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration progression. However, the role of miRNA‑301a‑3p human gastric cancer (GC), specifically activation NF‑κB signaling, remains unclear. The aim present study was to investigate expression GC progression molecular mechanisms as regards regulation signaling. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) used detect paired normal tissues. association...
Hypoxia-induced cardiomyocyte apoptosis is one of the leading causes heart failure. Nuclear respiratory factor 1 (NRF-1) was suggested as a protector against cell apoptosis; However, mechanism not clear. Therefore, aim this study to elucidate role NRF-1 in hypoxia-induced H9C2 and explore its effect on regulating death receptor pathway mitochondrial pathway. overexpressed or knocked down cells, which were then exposed hypoxia condition for 0, 3, 6, 12, 24 h. Changes proliferation, viability,...
This study aimed to delineate the diagnostic significance of miR-182-5p by investigating its influence on myocardial apoptosis and function, employing both in vivo vitro infarction models.A rat model was established. Myocardial area detected using 2,3,5-chlorotriphenyltetrazolium (TTC) method, enzyme spectrums were measured enzyme-linked immunosorbent assay (ELISA), structure hematoxylin eosin (HE) staining, TUNEL expression levels apoptosis-related molecules real-time fluorescence...
Abstract We aim to investigate the association between plasma endothelial microparticles (EMPs) and contrast-induced nephropathy of patients underwent coronary angiography. The were divided into normal renal function group dysfunction based on estimated glomerular filtration rate (eGFR). Among 180 cases, 117 received determination EMP serum creatinine after percutaneous intervention (PCI) and/or contrast-induced-nephropathy (CIN) non-CIN group. EMPs collection performed, together with...
(1) Background: In-stent Restenosis (ISR) is a major factor influencing the prognosis and revascularization of target lesions. The plaque composition unclear; therefore, it critical to investigate ISR identify clinical intervention markers. (2) Methods: This study was conducted on 36 patients with drug-eluting stent restenosis. were classified into Low Neutrophil–Lymphocyte Ratio (L-NLR) High (H-NLR) according median NLR level patients. Discrepancies in current information such as baseline...
Effects of toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway on expression angiotensinogen and AT1a were investigated, to explore the role TLR4/NF-κB signaling in cardiovascular disease. Neonatal rat left ventricular myocytes (NRVMs) cultured cardiomyocytes identified by immunocytochemical staining sarcomeric α-actin. NRVMs treated with lipopolysaccharide (LPS) at a dose 10, 100 1,000 ng/ml, RT-PCR was performed 24 h later detect TLR4, (ATG) mRNA level. pretreated caffeic acid...
Abstract Hypoxia is a primary inducer of cardiomyocyte injury, its significant marker being hypoxia-induced apoptosis. Nuclear respiratory factor-1 (NRF-1) and hypoxia-inducible factor (HIF)-1α are transcriptional regulatory elements implicated in multiple biological functions, including oxidative stress response. However, their roles apoptosis remain unknown. The effect HIF-α, together with NRF-1, exerts on also remains unclear. We established myocardial hypoxia model investigated the...
Abstract Objective There is limited literature on procedure of primary PCI in catheterization laboratory. This study was designed to assess the impact electrocardiogram-guided immediate intervention culprit lesion with a single guiding catheter ST-elevation myocardial infarction (STEMI) patients door-to-balloon (D2B) time and clinical outcomes. Methods In this prospective, randomized center study, 560 STEMI who underwent from February 2017 July 2019 were into two groups. group, (MAC3.5 or JL...
Due to its rarity, duodenal papillary carcinoma (DPC) is seldom studied as a unique disease and no specific molecular features or treatment guidelines are provided.Whole-exome sequencing was performed gain new insights into the DPC mutation landscape identify potential signalling pathways therapeutic targets. Mechanistically, immunohistochemistry (IHC), immunofluorescence, RNA-seq, ATAC-seq in vitro cell function experiments were confirm underlying mechanisms.We described mutational of for...
Abstract Background: Hypoxia is a primary inducer of cardiomyocyte injury, its significant marker being hypoxia-induced apoptosis. Nuclear respiratory factor-1 (NRF-1) and hypoxia-inducible factor-1α (HIF-1α) are transcriptional regulatory elements implicated in multiple biological functions, including oxidative stress response. However, their roles apoptosis remain unknown. The effect HIF-α, together with NRF-1, exerts on also remains unclear. Methods: We established myocardial hypoxia...