A5102830331- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Inflammasome and immune disorders
- Liver Disease and Transplantation
- Advanced Glycation End Products research
- Postharvest Quality and Shelf Life Management
- Traditional Chinese Medicine Analysis
- Arsenic contamination and mitigation
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Cancer-related molecular mechanisms research
- Plant Stress Responses and Tolerance
- Hepatitis B Virus Studies
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and disorders
- Immune Response and Inflammation
- Plant-Microbe Interactions and Immunity
- Photosynthetic Processes and Mechanisms
- Liver physiology and pathology
- Ginseng Biological Effects and Applications
Capital Medical University
2011-2025
Fujian Medical University
2024
Jiangxi Agricultural University
2022-2023
Capital University
2011-2023
Ludong University
2020
Zhejiang University
2020
Southwest University
2015
Jiangsu University
2013
Beijing YouAn Hospital
2005
Cross-talk between various hormones is important in regulating many aspects of plant growth, development, and senescence, including fruit ripening. Here, exogenous ethylene (ETH, 100 μL/L, 12 h) rapidly accelerated 'Hayward' kiwifruit (Actinidia deliciosa) softening production was enhanced by supplementing with continuous treatment methyl jasmonate (MeJA, μM/L, (ETH+MeJA). ETH+MeJA ACC synthase (ACS) activities 1-aminocyclopropane-1-carboxylic acid (ACC) accumulation but not oxidase (ACO)...
Catalase (CAT) is an important antioxidant enzyme in plants that plays a key role plant growth and stress responses. CAT usually encoded by small gene family has been cloned functionally studied some species, such as Arabidopsis, wheat cucumber, but its specific roles rice are not clear at present. In this study, we identified three genes (OsCAT1, OsCAT2 OsCAT3) the genome performed systematic bioinformatics analysis. RT-PCR analysis revealed OsCAT1-OsCAT3 was primarily expressed vegetative...
Aroma is an important organoleptic quality for fruit and has a large influence on consumer preference. Kiwifruit esters undergo rapid substantial changes contributing to the flavor during ripening. Part of enzymes their coding genes have been indicated potential candidates flavor-related synthesis. However, there still exist obvious gaps in biosynthetic pathways mechanisms regulating ester biosynthesis kiwifruit remain unknown.Using gas chromatography-mass spectrometry (GC-MS), volatile...
Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue as its progression increases risks of multisystem morbidity and mortality. Recent evidence indicates more complex relationship between hypertension NAFLD than previously thought. In this study, comprehensive literature search was used to gather information supporting the comorbidity phenomenon NAFLD. Then, systems biology approach applied identify potential genes mechanisms simultaneously associated with With...
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent in China. Sinisan (SNS) is a traditional Chinese medicine formula that been widely used treating chronic diseases, including NAFLD. However, its underlying biological mechanisms are still unclear. In this study, we employed network pharmacology approach consisting of overlapped terms- (genes or pathway terms-) based analysis, protein-protein interaction (PPI) network-based and PPI clusters identification. Unlike previous...
Tongxinluo (TXL) is one of the most common traditional Chinese medicines and plays a vital role in treating atherosclerosis (AS). Endothelial cell (EC) pyroptosis crucial development AS. Previous research revealed inhibitory function TXL EC apoptosis autophagy. However, whether can inhibit ECs has not been determined.To explore influence on determine its underlying mechanism action AS.The components were determined by ultra-performance liquid chromatography coupled with photodiode array...
Acute-on-chronic liver failure (ACLF) is a global intractable disease. HMGB1-induced hepatocyte pyroptosis expanding inflammatory responses contributes to the pathogenesis of ACLF. The JDNW formula (JDNWF) has significant clinical effect on ACLF, but its hepatoprotective mechanisms remain elusive. To explore potential molecular JDNWF in ACLF by pyroptosis. Rats were divided into normal, Caspase-1 inhibitor, HMGB1 JDNW, JDNW+Caspase-1 inhibitor and JDNW+HMGB1 groups. rat model was established...
Abstract The pathogenesis of Acute-on-chronic liver failure (ACLF) involves several forms cell death, such as pyroptosis, apoptosis, and necroptosis, which consist PANoptosis. To explore PANoptosis a regulated death pathway in ACLF. Firstly, bioinformatic strategy was used to observe the role ACLF identify differentially expressed genes related Enrichment analysis showed that PANoptosis-related pathways were up-regulated We screened out BAX from intersection DEGs. Secondly, we articles...
High mobility group box-1 (HMGB1) plays an important role in various liver injuries. In the case of acute injury, it leads to aseptic inflammation and other reactions, also regulates specific cell death responses chronic injury. HMGB1 has been demonstrated be a good therapeutic target for treating failure. Quercetin (Que), as antioxidant, is potential phytochemical with hepatocyte protection considered inhibitor HMGB1. However, mechanism its hepatoprotective effects remains characterized....
Adenoid hypertrophy can lead to adenoidal mouth breathing, which result in "adenoid face" and, severe cases, even respiratory tract obstruction. The Fujioka ratio method, calculates the of adenoid (A) nasopharyngeal (N) space an adenoidal-cephalogram (A/N), is a well-recognized and effective technique for detecting hypertrophy. However, this process time-consuming relies on personal experience, so fully automated standardized method needs be designed. Most current deep learning-based methods...
Acute-on-chronic liver failure (ACLF) is a critical disease with high fatality rate. Immune dysfunction and inflammatory responses are key risk factors in ACLF. Pyroptosis form of programmed cell death characterized by the release cytokines, which causes strong responses. High mobility group box-1 (HMGB1) could induce pyroptosis closely related to However, role HMGB1-induced hepatocyte ACLF has never been proposed; whether participates development mechanisms involved barely understood.This...
As a frequent cause of death in cancer patients, liver usually occurs hepatitis B and cirrhosis. In China, Chinese people have been using traditional medicine (TCM) treating various chronic diseases, which could effectively improve the symptoms slow down progression diseases. However, due to complexity rules TCM prescription, their action mechanisms are still not clearly understood, may affect popularization effective prescriptions. This study aims identify core herbs treatment B, cirrhosis,...
Acute-on-chronic liver failure (ACLF) is a severe, complicated human disease. E2F1-mediated apoptosis plays an important role in ACLF development. Jieduan-Niwan (JDNW) formula, traditional Chinese medicine (TCM), has shown remarkable clinical efficacy treatment. However, the hepatoprotective mechanisms of formula are barely understood.This study aimed to investigate JDNW treatment by specifically regulating apoptotic signaling pathways rats.The components were determined high-performance...
Radiofrequency (RF) catheter ablation has emerged as an effective alternative for the treatment of atrial fibrillation (AF), but lesions will result in swelling and hematoma local surrounding tissue, triggering inflammatory cell infiltration increased release cytokines. Some studies have shown that response may be related to early occurrence AF. The most direct way inhibit perioperative inflammation is use anti-inflammatory drugs such glucocorticoids. Here, we prepared polylactic-co-glycolic...
Acute-on-chronic liver failure (ACLF) is a serious and complicated disease that threatens human health because its pathogenesis unclear, the outcome of current therapies has been less than satisfactory. A national famous doctor traditional Chinese medicine, Qian Ying, created Jieduan-Niwan Formula (JDNW), based on his long-term clinical experience. However, despite good outcome, biological mechanism by which it works unknown. In study, we established an ACLF rat model administering serum...
Acute on chronic liver failure (ACLF) is a syndrome of acute that occurs the basis disease, which characterized by rapid deterioration in short period and high mortality. High mobility group box 1 (HMGB1) may be involved pathological process ACLF; its specific role remains to further elucidated. Our previous studies have shown quercetin (Que) exerts anti-oxidant anti-apoptotic effects inhibiting HMGB1 vitro. The present study aimed investigate effect Que injury ACLF rats.The contents ALT,...
Acute-on-chronic liver failure (ACLF) is a clinical syndrome with acute jaundice and coagulation dysfunction caused by various inducements on the basis of chronic disease. Western medical treatment limited. Previous studies have confirmed that Jieduan-Niwan Formula (JDNW Formula), an empirical prescription for ACLF, can inhibit inflammation resist hepatocyte apoptosis. However, potential targets mechanisms still need to be explored.In this study, network pharmacological analysis was...
Acute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which characterized by pathophysiological process of inflammation-related dysfunction energy metabolism. Jieduan-Niwan formula (JDNWF) eutherapeutic Chinese medicine for ACLF. However, the intrinsic mechanism its anti-ACLF effect still need to be studied systematically.This study aimed investigate JDNWF against ACLF based on altered substance metabolic profile in expression levels related molecules.The...