A5066779872- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Lipid metabolism and disorders
- Traditional Chinese Medicine Studies
- Immune Response and Inflammation
- Hematopoietic Stem Cell Transplantation
- Cell death mechanisms and regulation
- Thermal Regulation in Medicine
- Eicosanoids and Hypertension Pharmacology
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Oral Health Pathology and Treatment
- Healthcare and Venom Research
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Dermatological and COVID-19 studies
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
Capital Medical University
2017-2022
Capital University
2020-2022
Beijing Ditan Hospital
2003
Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue as its progression increases risks of multisystem morbidity and mortality. Recent evidence indicates more complex relationship between hypertension NAFLD than previously thought. In this study, comprehensive literature search was used to gather information supporting the comorbidity phenomenon NAFLD. Then, systems biology approach applied identify potential genes mechanisms simultaneously associated with With...
Acute-on-chronic liver failure (ACLF) is a severe, complicated human disease. E2F1-mediated apoptosis plays an important role in ACLF development. Jieduan-Niwan (JDNW) formula, traditional Chinese medicine (TCM), has shown remarkable clinical efficacy treatment. However, the hepatoprotective mechanisms of formula are barely understood.This study aimed to investigate JDNW treatment by specifically regulating apoptotic signaling pathways rats.The components were determined high-performance...
Qingdu Decoction (QDT) is a traditional Chinese medicine (TCM) that was derived from Xiaochengqi Decoction, famous decoction documented in the book of Treatise on Exogenous Febrile Disease Eastern Han Dynasty. According to our years clinical application, QDT showed satisfactory efficacy treatment endotoxemia acute-on-chronic liver failure (ACLF). However, underlying molecular mechanisms remain largely unknown. In this study, we aimed systematically evaluate intervention effect rats and...
Objective: To improve the effects of treatment severe acute respiratory syndrome (SARS) and to explore clinical significance integrated traditional Chinese medicine western (ICWM) in SARS its influence on chief indexes process disease.Methods: The study involving observation 135 patients was conducted randomized, synchronously controlled open way. were divided into two groups, 68 ICWM group 67 control group, all whom treated with same basic medicine, but drugs for clearing Heat, detoxifying...
Objective: Chronic graft-versus-host disease (cGVHD) is a major long-term complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) . It important to study the changes of serum biomarkers expression in patients for early diagnosis and treatment. Methods: The levels five protein markers (IL-1b, IL-16, CXCL9, CCL19, CCL17) with or without cGVHD allo-HSCT were detected by liquid suspension microarray. Results: Compared control group cGVHD, CXCL9 CCL17 significantly...
Qingdu Decoction (QDD) is a traditional Chinese medicine formula for treating chronic liver injury (CLI). Materials and methods. A network pharmacology combining experimental validation was used to investigate potential mechanisms of QDD against CLI. We firstly screened the bioactive compounds with analysis platform system (TCMSP) gathered targets Then, we constructed compound-target protein-protein interaction (PPI) enriched core in Kyoto Encyclopedia Genes Genomes (KEGG) signaling...
To investigate the protective effects and underlying mechanism of Qingdu decoction (QDD) on experimental rats with severe liver injury induced by thioacetamide (TAA).A total 40 Wistar were randomly divided into normal group (n = 10) 30). Rats administrated same content saline in group. The pretreated TAA at dose 12 mg/kg lasting 8 weeks, from 9th week to 12th week, concentration 36 mg/kg. During period, three subgroups 10 each) simultaneously based treatment categories: model group,...
Abstract Background Liver failure is considered as the inability of liver to perform its normal synthetic and metabolic function. Our previous data showed that Jieduan-Niwan formula (JDNW) induced failure, while underlying mechanism remains unknown. Methods In present study, we performed a network pharmacology analyze bioactive ingredients related targets. Compound target JDNW were retrieved from Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), targets diseases obtained...
Ethnopharmacological relevance: Qingdu Decoction (QDT) is a traditional Chinese medicine (TCM) that was derived from Xiaochengqi Decoction, famous decoction documented in the book of Treatise on Exogenous Febrile Disease Eastern Han Dynasty. According to our years clinical application, QDT showed satisfactory efficacy treatment endotoxemia acute-on-chronic liver failure (ACLF). However, underlying molecular mechanisms remain largely unknown.Aim studyIn this study, we aimed systematically...