A5101591883- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Inflammasome and immune disorders
- Liver Disease and Transplantation
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Macrophage Migration Inhibitory Factor
- Diet, Metabolism, and Disease
- Medicinal Plant Pharmacodynamics Research
- Healthcare and Venom Research
- Connective Tissue Growth Factor Research
- Cell death mechanisms and regulation
- Lipid metabolism and disorders
- Advancements in Transdermal Drug Delivery
- Bone Metabolism and Diseases
- Dermatology and Skin Diseases
- TGF-β signaling in diseases
- Hepatitis B Virus Studies
Capital Medical University
2020-2025
Capital University
2020-2023
Beijing University of Chinese Medicine
2006
Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue as its progression increases risks of multisystem morbidity and mortality. Recent evidence indicates more complex relationship between hypertension NAFLD than previously thought. In this study, comprehensive literature search was used to gather information supporting the comorbidity phenomenon NAFLD. Then, systems biology approach applied identify potential genes mechanisms simultaneously associated with With...
Abstract The pathogenesis of Acute-on-chronic liver failure (ACLF) involves several forms cell death, such as pyroptosis, apoptosis, and necroptosis, which consist PANoptosis. To explore PANoptosis a regulated death pathway in ACLF. Firstly, bioinformatic strategy was used to observe the role ACLF identify differentially expressed genes related Enrichment analysis showed that PANoptosis-related pathways were up-regulated We screened out BAX from intersection DEGs. Secondly, we articles...
Macrophages are increasingly recognized as crucial therapeutic targets in the treatment of diverse pathological conditions. While considerable research has focused on macrophage-related mechanisms within Traditional Chinese Medicine (TCM), there remains a notable absence comprehensive quantitative analyses this field. This study aims to examine evolutionary trajectory TCM from 2003 2023, providing insights guide future investigative directions. We searched for articles published between and...
Acute-on-chronic liver failure (ACLF) is a severe, complicated human disease. E2F1-mediated apoptosis plays an important role in ACLF development. Jieduan-Niwan (JDNW) formula, traditional Chinese medicine (TCM), has shown remarkable clinical efficacy treatment. However, the hepatoprotective mechanisms of formula are barely understood.This study aimed to investigate JDNW treatment by specifically regulating apoptotic signaling pathways rats.The components were determined high-performance...
Acute-on-chronic liver failure (ACLF) is a clinical syndrome with acute jaundice and coagulation dysfunction caused by various inducements on the basis of chronic disease. Western medical treatment limited. Previous studies have confirmed that Jieduan-Niwan Formula (JDNW Formula), an empirical prescription for ACLF, can inhibit inflammation resist hepatocyte apoptosis. However, potential targets mechanisms still need to be explored.In this study, network pharmacological analysis was...
Acute-on-chronic liver failure (ACLF) is a refractory disease with high mortality, which characterized by pathophysiological process of inflammation-related dysfunction energy metabolism. Jieduan-Niwan formula (JDNWF) eutherapeutic Chinese medicine for ACLF. However, the intrinsic mechanism its anti-ACLF effect still need to be studied systematically.This study aimed investigate JDNWF against ACLF based on altered substance metabolic profile in expression levels related molecules.The...
Acute-on-chronic liver failure (ACLF) is a critical and refractory disease hepatic disorder accompanied by immune dysfunction. Thus, it essential to explore key immune-related genes of ACLF investigate its mechanisms. We used two public datasets (GSE142255 GSE168048) perform various bioinformatics analyses, including WGCNA, CIBERSORT, GSEA. also constructed an protein-protein interaction (PPI) network obtain hub differentially expressed (DEGs) predict corresponding miRNAs. Finally, rat model...
Diabetic nephropathy, one of the major causes death diabetes patients, is diagnosed as thickening glomerular basement membrane and progressive expansion mesangium tubulointerstitium. Intensive studies have shown that hyperglycemia key factor for renal sclerosis which can lead to end-stage disease diabetic patients.1,2 Our previous demonstrated Xiaoke granule inhibit progression nephropathy. However, its mechanisms remain unknown.3,4 In this study, we found coincidently depresses transforming...
Qingdu Decoction (QDD) is a traditional Chinese medicine formula for treating chronic liver injury (CLI). Materials and methods. A network pharmacology combining experimental validation was used to investigate potential mechanisms of QDD against CLI. We firstly screened the bioactive compounds with analysis platform system (TCMSP) gathered targets Then, we constructed compound-target protein-protein interaction (PPI) enriched core in Kyoto Encyclopedia Genes Genomes (KEGG) signaling...
Abstract ACLF (Acute on chronic liver failure) is a systemic inflammatory disease. PANoptosis newly discovered regulated cell death (RCD) that occurs in the infectious and diseases. The purpose of this study to investigate presence failure. We selected articles from PubMed Web Science databases collect data these through bibliometrics, mining, other methods, then integrated analyzed data. Then, we used public dataset (GSE139602) obtain central differentially expressed genes (DEGs) perform...
Objective To develop an method for detecting the characteristic chromatograms of Qihong decoction by high-performance liquid chromatography coupled with diode arry and evaporative light-scattering detectors (HPLC-DAD-ELSD). Methods The determination was carried out Venusil MP-C18 (250 mm × 4.6 mm, 5 μm) column,using acetonitrile-0.2% formic acid as mobile phase gradient elution at a flow rate 1.0 ml/min detected wave length 254 nm, 290 365 nm. The drift tube temperature ELSD set 70 ℃,...
Abstract Background Liver failure is considered as the inability of liver to perform its normal synthetic and metabolic function. Our previous data showed that Jieduan-Niwan formula (JDNW) induced failure, while underlying mechanism remains unknown. Methods In present study, we performed a network pharmacology analyze bioactive ingredients related targets. Compound target JDNW were retrieved from Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), targets diseases obtained...