A5101579057- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Healthcare and Venom Research
- Cholesterol and Lipid Metabolism
- Nerve injury and regeneration
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Diabetic Foot Ulcer Assessment and Management
- Medical Research and Treatments
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Botulinum Toxin and Related Neurological Disorders
- Flavonoids in Medical Research
- Lipid metabolism and disorders
- Inflammatory mediators and NSAID effects
- Macrophage Migration Inhibitory Factor
- Musculoskeletal synovial abnormalities and treatments
- Exercise and Physiological Responses
- Autophagy in Disease and Therapy
- S100 Proteins and Annexins
- Plant-based Medicinal Research
- Genetic and Kidney Cyst Diseases
Capital Medical University
1998-2025
Shaanxi Provincial People's Hospital
2020
Shanxi Medical University
2020
Northwest A&F University
2017
Shandong Provincial Hospital
2016
Shandong University
2016
Beijing Hospital of Traditional Chinese Medicine
2007-2013
Beijing Shijitan Hospital
2012
Beijing University of Chinese Medicine
2005-2009
Background Treatment of diabetes mellitus with Traditional Chinese Medicine has a long history. The aim this study is to establish the safety and efficacy traditional medicine combined glibenclamide treat type 2 mellitus. Methods In controlled, double blind, multicentre non-inferiority trial, 800 patients unsatisfactory glycemic control (fasting glucose 7–13 mmol/L HbA1c 7–11%) were randomly assigned receive Xiaoke Pill, compound herbs glibenclamide, or Glibenclamide in two groups – drug...
Piglets are characteristically cold intolerant and thus susceptible to high mortality. However, browning of white adipose tissue (WAT) can induce non-shivering thermogenesis as a potential strategy facilitate the animal's response cold. Whether exposure subcutaneous WAT (sWAT) in piglets similar manner it humans remains largely unknown. In this study, were exposed acute (4°C, 10 h) or chronic (8°C, 15 days), genes proteins uncoupling protein 1 (UCP1)-dependent independent thermogenesis,...
This study was devoted to identifying natural thrombin inhibitors from traditional Chinese medicine (TCM) and evaluating its biological activity
Abstract Background Tangshenning (TSN) is a safe and effective formula to treat diabetic nephropathy (DN), clinical studies have demonstrated that its therapeutic effects are related oxidative stress improvements in patients. Herein, this study aims explore the potential mechanism of how TSN alleviates renal tubular injury. Methods The ultrahigh pressure liquid chromatography-quadrupole-time flight mass spectrometry (UPLC-QTOF/MS) was used identify chemical composition serum components TSN....
Giant cell tumour of the distal radius is a locally aggressive lesion. In this study, we performed wrist arthrodesis reconstruction with an ipsilateral double barrel segmental ulnar bone graft combined modified Sauve-Kapandji procedure for giant radius. From January 2007 to September 2013, followed eight patients mean duration 36 months. One patient developed recurrence and was treated by amputation; other seven achieved radiological union in about 8 There no instability, deformation or...
Diabetic peripheral neuropathy (DPN) is a common microvascular complication of diabetes associated with high disability rate and low quality life. Tang-Luo-Ning (TLN) an effective traditional Chinese medicine for the treatment DPN. To illustrate underlying neural protection mechanisms TLN, effect TLN on electrophysiology sciatic nerve morphology was investigated in model streptozotocin-induced DPN, as well mechanism. Sciatic motor conduction velocity digital sensory were reduced DPN...
Diabetic peripheral neuropathy (DPN) is one of the most common complications diabetes with limited therapies. Tang Luo Ning (TLN), a traditional Chinese medicine compound, has been proved to be effective in treatment DPN clinical and experimental studies. However, potential metabolic mechanism TLN for still unclear. Here therapeutic effect on was studied, HPLC-IT-TOF/MS used explore changes related induced by high glucose. Furthermore, pathway analysis TLN. As result, could improve nerve...
Tang-luo-ning (TLN) is a traditional Chinese herbal recipe that has been used to treat diabetic peripheral neuropathy (DPN); nevertheless, the underlying mechanism remains unclear. This study was aimed investigate microRNA (miRNA) expression profile in rats treated with TLN, and target genes were predicted. Male Sprague-Dawley randomly divided into control, diabetes, TLN-treated diabetes groups. Diabetes induced streptozotocin, TLN (5 g/kg/day) orally given for eight weeks. Then, sciatic...
Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the most common cause death in diabetic patients. DN progression associated with podocyte damage due to reduced autophagy caused by mTORC1 activation. Tangshenning (TSN) has been shown reduce proteinuria, protect renal function, damage. Still, effect TSN on autophagic activity podocytes remains unclear. Herein, vitro experiments using high glucose-induced injury model were performed. Results showed that...
Acute-on-chronic liver failure (ACLF) is a critical and refractory disease hepatic disorder accompanied by immune dysfunction. Thus, it essential to explore key immune-related genes of ACLF investigate its mechanisms. We used two public datasets (GSE142255 GSE168048) perform various bioinformatics analyses, including WGCNA, CIBERSORT, GSEA. also constructed an protein-protein interaction (PPI) network obtain hub differentially expressed (DEGs) predict corresponding miRNAs. Finally, rat model...
Objective To observe the effect of treating Diabetic Peripheral Neuropathy with Acupoint Injection. Methods 65 patient DPN were randomly recruited into a control group and treatment after adjusting stage. The was treated acupuncture, while Safflower inoculation fluid acupuncture point injects. Nerve function parameter (MDNS、 NCV) clinical symptoms observed 3 therapeutic courses. Results in apparently improved (P<0.05) . Conclusion Acupuncture injected may improve nerve functions patients....
Alzheimer's Disease (AD) is a neurodegenerative disease that has an insidious onset and slow progression. Despite the vast amount of work done on AD, its pathogenesis still unclear, resulting in lack specific treatments. This deficit currently large focus for both Traditional Chinese Medicine (TCM) as well Western medical research. Although clear mechanism AD missing, current “Aβ cascade” theory core component thinking regarding . One school thought holds β-amyloid (Aβ) aggregation key...