A5063890719- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Berberine and alkaloids research
- Environmental Toxicology and Ecotoxicology
- Developmental Biology and Gene Regulation
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Heavy Metal Exposure and Toxicity
- Natural Antidiabetic Agents Studies
- Neuroscience and Neuropharmacology Research
- Molecular Sensors and Ion Detection
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Pancreatic function and diabetes
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Drug Transport and Resistance Mechanisms
- Retinal Development and Disorders
- Mercury impact and mitigation studies
- NF-κB Signaling Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biofuel production and bioconversion
Children's Hospital of Capital Institute of Pediatrics
2021-2025
Shandong Academy of Sciences
2018-2025
Qilu University of Technology
2018-2025
North China University of Science and Technology
2025
Ministry of Ecology and Environment
2024
Lockheed Martin (United States)
2024
Jiangsu University
2021-2022
Biology Institute of Shandong Academy of Sciences
2022
North China Electric Power University
2019-2020
Luohe Medical College
2020
With the increasing applications in various fields, release and accumulation of zinc oxide (ZnO) nanomaterials ultimately lead to unexpected consequences environment human health. Therefore, toxicity comparison among ZnO with different shape/size their adverse effects need better characterization. Here, we utilized zebrafish larvae neuroblastoma cells SH-SY5Y compare toxic nanoparticles (ZnO NPs), short nanorods (s-ZnO NRs), long NRs (l-ZnO NRs). We found developmental- neuro-toxicity levels...
Although Parkinson's disease (PD) is the second most common neurodegenerative disorder, preventative or therapeutic agents for treatment of PD are limited. Eucommia ulmoides Oliver (EuO) widely used as a traditional herb to treat various diseases. EuO bark extracts have been reported possess anti-PD activity. Here, we investigated whether leaves (EEuOL) also effects on since similar components and clinical applications found between barks this tree. We identified chemical composition EEuOL...
Nowadays, silica nanoparticles (SiNPs) as one of the most productive nano-powder, has been extensively applied in various filed. The potential harm SiNPs previously received severe attention. A bulk researches have proven adverse effect on health ecological organisms and human. However, neurotoxic impacts SiNPs, still remain stage exploration. effects need to be further explored. And toxic mechanism needs comprehensive clarification. Herein, neurotoxicity concentrations (100, 300, 1000...
The lack of disease-modifying therapeutic strategies against epileptic seizures has caused a surge in preclinical research focused on exploring and developing novel candidates for epilepsy. Compounds from traditional Chinese medicines (TCMs) have gained much attention plethora neurological diseases, including Herein, the first time, we evaluated anticonvulsive effects schaftoside (SS), TCM, pentylenetetrazol (PTZ)-induced zebrafish examined underlying mechanisms. We observed that SS...
Objective: To explore the clinical and genetic characteristics follow-up status of pediatric patients with hepatic glycogen storage disease in order to further improve prognosis. Methods: The data hospitalized children diagnosed Department Gastroenterology at Children's Hospital Capital Institute Pediatrics from January 2010 April 2023 were collected retrospectively analyzed. results laboratory examination gene sequencing analyzed, number cases that exceeded three (n) grouped according...
The scorpion Buthus martensii Karsch is edible and has been an essential resource in traditional Chinese medicine for treating numerous diseases. In this study, two small peptides from B. hydrolysates were examined to elucidate their potential against gastric cancer. (AK GK) identified using the LC-QTOF-MS-based approach. silico prediction of therapeutic targets, MGC-803 cells transgenic zebrafish models, immunoblotting experiments used reveal molecular mechanism action peptides. AK GK...
Inflammatory bowel disease (IBD) is characterized by uncontrolled, chronic relapsing inflammation in the gastrointestinal tract and has become a global healthcare problem. Here, we aimed to illustrate anti-inflammatory activity underlying mechanism of methyl 3-bromo-4,5-dihydroxybenzoate (MBD), compound derived from marine organisms, especially IBD, using zebrafish model. The results indicated that MBD could inhibit inflammatory responses induced CuSO4, tail amputation LPS zebrafish....
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, yet effective agents for its prevention and therapy remain highly limited. Epicoccin A, a significant secondary metabolite from Exserohilum sp., demonstrates various biological activities, however, neuroprotective effects have not been elucidated. Here, we investigated therapeutic potential of epicoccin A PD by evaluating impact on neural phenotype, reactive oxygen species (ROS) generation, locomotor activity...
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder, affecting an increasing number of older adults. Despite extensive research, a definitive cure remains elusive. Eucommia ulmoides Oliv. leaves (EUOL) have been reported to exhibit protective effects on diseases, however, their efficacy, key active constituents, and pharmacological mechanisms are not yet understood. This study aims explore optimal constituents EUOL regarding anti-PD activity its...
Reserpine is used as a cheap and effective first-line antihypertensive, presently, it applied treatment for difficult-to-control cases of hypertension. Despite its significance, reserpine’s neuroendocrine toxicity remains largely underexplored. Here, we investigated the effects reserpine on development, locomotion, central nervous system (CNS) neurons, thyroid expression genes related to neurodevelopment, endocrine, learning memory, depression in zebrafish exposed different doses ranging...