A5101829919- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Echinoderm biology and ecology
- Phytochemicals and Antioxidant Activities
- Antenna Design and Analysis
- Zebrafish Biomedical Research Applications
- Pharmacological Effects of Natural Compounds
- Marine Sponges and Natural Products
- GaN-based semiconductor devices and materials
- Advanced Antenna and Metasurface Technologies
- Seaweed-derived Bioactive Compounds
- Protein Hydrolysis and Bioactive Peptides
- Semiconductor materials and devices
- Molecular Sensors and Ion Detection
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Lipid metabolism and disorders
- Bioactive natural compounds
- Antibiotic Resistance in Bacteria
- Analytical chemistry methods development
- Microbial Natural Products and Biosynthesis
- Phytochemical compounds biological activities
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Lipid Membrane Structure and Behavior
Qilu University of Technology
2018-2025
Shandong Academy of Sciences
2018-2025
Shihezi University
2023-2025
Xi’an University of Posts and Telecommunications
2023-2024
Chang'an University
2024
Xi’an Jiaotong-Liverpool University
2023-2024
Tulane University
2023-2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
University of Liverpool
2023-2024
The overall response of cisplatin-based chemotherapy in bladder urothelial carcinoma (BUC) remains unsatisfactory due to the complex pathological subtypes, genomic difference, and drug resistance. genes that associated with cisplatin resistance remain unclear. Herein, we aimed identify BUC. EXPERIMENTAL DESIGN: cytotoxicity was evaluated six cancer cell lines compare their responses cisplatin. T24 cells exhibited lowest sensitivity therefore selected explore mechanisms We performed...
Although Parkinson's disease (PD) is the second most common neurodegenerative disorder, preventative or therapeutic agents for treatment of PD are limited. Eucommia ulmoides Oliver (EuO) widely used as a traditional herb to treat various diseases. EuO bark extracts have been reported possess anti-PD activity. Here, we investigated whether leaves (EEuOL) also effects on since similar components and clinical applications found between barks this tree. We identified chemical composition EEuOL...
Silibinin is a flavonoid compound extracted from the seeds of Silybum marianum (L.) Gaertn. It has functions liver protection, blood-lipid reduction and anti-tumor effects. However, potential molecular mechanism silibinin against tumors still unknown. This study aimed to assess effects in adenoid cystic carcinoma (ACC2) cells Balb/c nude mice, explore its based on network pharmacology prediction experimental verification. A total 347 targets interacting with were collected, 75 related tumor...
The pathological mechanisms and treatments of osteoarthritis (OA) are critical topics in medical research. This paper reviews the regulatory hydrogen sulfide (H2S) OA therapeutic potential H2S donors. review highlights importance changes endogenous pathway development systematically elaborates on role as a third gaseous transmitter that regulates inflammation, oxidative stress, pain associated with OA. It also explains how can lessen bone joint inflammation by inhibiting leukocyte adhesion...
Marine natural products are important sources of novel drugs. In this study, we isolated 4-hydroxyphenylacetic acid (HPA) from the marine-derived fungus Emericellopsis maritima Y39–2. The antithrombotic activity and mechanism HPA were reported for first time. Using a zebrafish model, found that had strong because it can significantly increase cardiac erythrocytes, blood flow velocity, heart rate, reduce caudal thrombus, reverse inflammatory response caused by Arachidonic Acid (AA). Further...
The scorpion Buthus martensii Karsch is edible and has been an essential resource in traditional Chinese medicine for treating numerous diseases. In this study, two small peptides from B. hydrolysates were examined to elucidate their potential against gastric cancer. (AK GK) identified using the LC-QTOF-MS-based approach. silico prediction of therapeutic targets, MGC-803 cells transgenic zebrafish models, immunoblotting experiments used reveal molecular mechanism action peptides. AK GK...
As dynamic systems, social networks exhibit continuous topological changes over time, and are typically modeled as temporal networks. In order to understand their characteristics, it is essential investigate community detection (TCD), which poses significant challenges compared static network analysis. These arise from the need simultaneously detect structures track evolutionary behaviors. To address these issues, we propose TCDA-NE, a novel TCD algorithm that combines clustering with convex...
(1) Background: Glycyrrhizic acid (GA) is the main component of traditional Chinese medicine Glycyrrhiza glabra. Many GA preparations in pharmaceutical market have good efficacy hepatoprotection and treatment liver diseases. However, pro-angiogenic effects for GA-based agents not been researched specifically. The aim this study was to investigate activity commonly used clinical practice screen representative angiogenesis promotor further elucidate mechanism action; (2) Methods: A zebrafish...
Fermented black garlic has multiple beneficial biological activities, including cardiovascular protection, anticancer, hepatoprotective, and antibacterial properties. In this study, metabolic differences in the properties of fresh were investigated via liquid chromatography quadrupole/time-of-flight-based metabolomics, leading to identification characteristic components. samples their Amadori products (AC) promoted angiogenesis, prevented thrombus formation by rescuing chemical-induced...
Neptunea arthritica cumingii (Nac) is a marine snail with high nutritional and commercial value; however, little known about its active peptides. In this study, two multi-functional peptides, YSQLENEFDR (Tyr-Ser-Gln-Leu-Glu-Asn-Glu-Phe-Asp-Arg) YIAEDAER (Tyr-Ile-Ala-Glu-Asp-Ala-Glu-Arg), were isolated purified from meat visceral mass extracts of Nac using multi-bioassay-guided method characterized by liquid chromatography-tandem spectrometry. Both peptides showed antioxidant,...
Danggui-Chuanxiong (DC) is a commonly used nourishing and activating blood medicine pair in many gynecological prescriptions modern Chinese medicine. However, its mechanism has not been clearly elucidated. Our research aimed at investigating the mechanisms of DC using network pharmacology zebrafish experiments. Network was to excavate potential targets treating thrombus. The antithrombotic, anti-inflammatory, antioxidant, vasculogenesis activities main components DC, ferulic acid (DC2),...
Abstract The hydrolysates from Apostichopus japonicus sea cucumber are an important source of nitrogen that may be added to foods. We evaluated the effect A. on inflammation‐associated leukocyte recruitment. results revealed migration site injury was significantly blocked by AJH‐1 (<10 kDa), suggesting a protective against CuSO 4 ‐induced neuromast damage in zebrafish model. Based liquid chromatography/time‐of‐flight/mass spectrometry, and metabolomic analysis, nine biomarker candidates...
Lipids are considered to be critical contributors nutrition, structural function, metabolic and other biological roles. They vary from one source another. Here, the lipids three common sources (soybean, egg yolk, shrimp head) were comprehensively compared characterized using lipidomics approach, together with UPLC-Q-Exactive Orbitrap/MS method. A total of 3027 lipid structures containing 778 fatty acids, 750 glycerolipids, 1283 glycerophospholipids, 200 sphingolipids, 16 sterol first...
flowers, associated with diverse biological effects, could be utilized as functional food ingredients to play a crucial role in human health. In this study, we examined the anti-PD activity of
Abstract L1 elements are retrotransposons currently active in mammals. Although L1s typically silenced most normal tissues, elevated expression is associated with a variety of conditions, including cancer, aging, infertility and neurological disease. These associations have raised interest the mapping human endogenous de novo insertions, methods been developed for this purpose. Adapting these to mouse genomes would allow us monitor vivo activity controlled, experimental conditions using...
Acetyl-11-keto-β-boswellic acid (AKBA), a triterpenoid from Boswellia serrate, is regarded as an angiogenesis inhibitor. However, its toxicity unknown. The aim of this study was to examine developmental and cardiotoxicity. A assay in zebrafish embryos/larvae 4 96 hours post-fertilization (hpf) performed cardiotoxicity designed 48 72 hpf. Markers oxidative stress related genes were selected access the possible mechanisms. According results, AKBA induced pericardium edema, yolk-sac abnormal...
The lipidomics and bioactivities of phospholipids from squid by-products were studied, the results provided a basis for their future application in nutritional pharmaceutical industry.
Seven main ginsenosides, including ginsenoside Re, Rb1, pseudoginsenoside F11, Rb2, Rb3, Rd, and F2, were identified by LC-QTOF MS/MS from root, leaf flower extracts of Panax quinquefolius. These promoted intersegmental vessel growth in a zebrafish model, indicating their potential cardiovascular health benefits. Network pharmacology analysis was then conducted to reveal the mechanisms activity treatment coronary artery disease. GO KEGG enrichment analyses elucidated that G protein-coupled...