A5017520572- Schizophrenia research and treatment
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Healthcare Decision-Making and Restraints
- Cognitive Functions and Memory
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Obsessive-Compulsive Spectrum Disorders
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Attention Deficit Hyperactivity Disorder
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- GABA and Rice Research
- Pharmacogenetics and Drug Metabolism
- Neural dynamics and brain function
- Hydrogen Storage and Materials
- Reproductive System and Pregnancy
- Autism Spectrum Disorder Research
- Lipid metabolism and biosynthesis
- Signaling Pathways in Disease
Peking University
2008-2023
Peking University Sixth Hospital
2008-2023
Guangdong Academy of Medical Sciences
2022
Guangdong Provincial People's Hospital
2022
National Clinical Research
2021
Ministry of Health of the Russian Federation
2015
State Key Laboratory of Pharmaceutical Biotechnology
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Objective: Diagnosis of schizophrenia is currently dependent on symptom-based criteria and lacks objective indicators. In this study, the authors investigated whether circulating miRNA can serve as a diagnostic biomarker for schizophrenia. Methods: Global plasma miRNAs were profiled in test cohort 164 patients 187 control subjects, using Solexa sequencing, TaqMan Low Density Array, quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays. The captured then validated by...
Purpose: This study aimed to investigate the efficacy and tolerability of aripiprazole, olanzapine risperidone in first-episode schizophrenia (FES). Methods: The eight-week, open, randomised was conducted six Chinese medical centres. Altogether, 498 FES subjects were aripiprazole ( n = 165), 168) or 165). Efficacy measured with Positive Negative Syndrome Scale (PANSS), Udvalg for Kliniske Undersogelser Side Effect Rating (UKU) functioning Personal Social Performance (PSP). Results: All three...
We performed an association study between three SNPs in the genes of 14-3-3 family and paranoid schizophrenia. SNP rs983583 G/A YWHAZ gene showed significant with Our indicated that was a potential susceptibility for schizophrenia population studied.
Abstract Frizzled 3 ( FZD3 ) gene is located on chromosome 8p21, a region that has been implicated in schizophrenia genetic linkage studies. The transmembrane receptor required for Wnt signal transduction cascades have thought to be involved producing the cytoarchitectural defects observed schizophrenia. Previous work showed strong association between locus and family‐based study. To confirm this issue further, we investigated four single nucleotide polymorphisms (SNPs) by case‐control study...
Abstract Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered being two most important neurotransmitters involved in pathophysiology schizophrenia. To study a possible role MAOA gene conferring susceptibility to schizophrenia, present genotyped variable number tandem repeat (VNTR) polymorphism 41 SNPs across this among 555 unrelated patients with paranoid schizophrenia 567 healthy controls. Quantitative...
Background Sustained attention deficits have been associated with schizophrenia. However, these findings were limited to patients schizophrenia and cannot be generalized a wider nonclinical sample schizotypal personality features. Objectives This study aimed examine the sensitivity of theory-driven test, Attention Response Task (SART), in individuals We also investigated relationships between different parameters SART dimensions Methods One hundred ninety-nine participants (74 schizophrenia,...
Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogenesis schizophrenia. Thus, genes in pathway candidates schizophrenia susceptibility. Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) succinic semialdehyde dehydrogenase (ALDH5A1) five primary enzymes glutamate synthetic degradative pathway. In order to investigate possible involvement these development...
Introduction: Cognitive impairment is a core feature of schizophrenia. The effects atypical antipsychotics on the cognitive functions patients with first-episode schizophrenia have not been comprehensively investigated so far. This study aims to compare neurocognitive risperidone, olanzapine, and aripiprazole for schizophrenia.Methods: was multicenter, randomized, open-label clinical trial. 546 were randomly divided into three medication groups, followed up 1 year. performance evaluated...
Several lines of evidence suggest that dysfunctions neurotransmitters are associated with schizophrenia. DOPA decarboxylase (DDC) is an enzyme involved directly in the synthesis dopamine and serotonin, indirectly noradrenaline. Therefore, DDC gene can be considered a candidate for We performed association study between three single nucleotide polymorphisms paranoid However, our no significant differences were found genotype distributions allele frequencies 80 schizophrenics 108 controls any...
To investigate the persistent remission rate (PRR) and its predictors within first year of antipsychotic treatment in first-episode schizophrenia (FES) patients.In a sample 301 FES patients who remained for 1 year, we assessed symptoms with Positive Negative Syndrome Scale (PANSS), cognition six domains functioning Personal Social Performance (PSP).In total, 75.4% (227/301) remaining reached (PR) one year. The PSP score was higher remitters than non-remitters at endpoint 1-year follow-up (P...
Objective: To explore the effect of long-term antipsychotics use on strength functional connectivity (FC) in brains patients with chronic schizophrenia. Method: We collected resting-state magnetic resonance imaging from 15 continuously treated schizophrenia (TCS), 19 minimally TCS (MTCS), and 20 healthy controls (HCs). Then, we evaluated compared whole-brain FC (FCS; including full-range, short-range, long-range FCS) among TCS, MTCS, HCs. Results: Patients MTCS showed reduced...
Abstract We genotyped six SNPs in the genes of p450 family among paranoid schizophrenics and normal controls. All subjects are unrelated Han Chinese. Three showed polymorphic, no significant differences allele or genotype frequencies were detected between patients Thus we obtained evidence for involvement polymorphisms schizophrenia population investigated.
Environmental stressors may influence immune surveillance in B lymphocytes and stimulate autoimmune responses via epigenetic DNA methylation modifications schizophrenia (SCZ).
Background Lipid storage myopathy (LSM) is an autosomal recessive inherited lipid and amino metabolic disorder with great clinical heterogeneity. Variations in the electron transfer flavoprotein dehydrogenase (ETFDH) gene cause multiple acyl-CoA deficiency (MADD), have a manifestation of LSM. Muscle biopsy helps clarify diagnosis LSM, next-generation sequencing (NGS) can be useful identifying genomic mutation sites. The MADD contributes to targeted therapy. Case presentation We report on...
Objective To describe negative symptoms in ultra-high-risk individuals of schizophrenia. Methods Twenty-two patients, 23 acute schizophrenia 18 stable patients from the Sixth Hospital Peking University were enrolled May 1st, 2012 to Mar 30th, 2013. The Positive and Negative Syndrome Scale (PANSS) for Assessment Symptoms (SANS) used assess each group. characteristic symptom among three groups was compared. Results The SANS scores group higher than those (58.68±21.29 vs....