A5105671813- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Gene expression and cancer classification
- Melanoma and MAPK Pathways
- Bioinformatics and Genomic Networks
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Ferroptosis and cancer prognosis
- FOXO transcription factor regulation
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- BRCA gene mutations in cancer
- RNA Interference and Gene Delivery
- Mechanisms of cancer metastasis
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
East China Normal University
2023-2025
Sun Yat-sen University
2025
Shanghai University of Traditional Chinese Medicine
2010-2025
Fuzhou University
2023-2024
Jilin Academy of Agricultural Sciences
2024
Zhejiang University
2023-2024
Guangzhou University
2024
Wuhan Union Hospital
2024
Jiujiang University
2023
Affiliated Hospital of Guizhou Medical University
2023
In the present study, a 36-year-old male presented with left scrotal enlargement without an obvious cause, accompanied by feeling of heaviness. Imaging examinations revealed testicular malignancy, patient underwent mass removal,and postoperative pathology results highly malignant germ cell tumor, tendency toward poorly differentiated embryonal carcinoma or seminoma. After surgery, condition deteriorated rapidly, and distant tumor metastasis occurred. Lymph node puncture consistent...
Genome-wide association studies (GWAS) have identified loci associated with kidney diseases, but the causal variants, genes, and pathways involved remain elusive. Here, we a disease gene called pancreatic progenitor cell differentiation proliferation factor (PPDPF) through integrating GWAS on function multiomic analysis. PPDPF was predominantly expressed in healthy proximal tubules of human mouse kidneys via single-cell Further investigations revealed that functioned as thiol-disulfide...
Abstract Base editors, including dual base are innovative techniques for efficient conversions in genomic DNA. However, the low efficiency of A-to-G conversion at positions proximal to protospacer adjacent motif (PAM) and A/C simultaneous editor hinder their broad applications. In this study, through fusion ABE8e with Rad51 DNA-binding domain, we generate a hyperactive ABE (hyABE) which offers improved editing region (A 10 -A 15 ) PAM, 1.2- 7-fold improvement compared ABE8e. Similarly,...
Protein arginine methylations are crucial post-translational modifications (PTMs) in eukaryotes, playing a significant regulatory role diverse biological processes. Here, we present our investigation into the detailed methylation pattern of C-terminal RG-rich region METTL14, key component m6A RNA machinery, and its functional implications biology disease. Using ETD-based mass spectrometry vitro enzyme reactions, uncover specific on METTL14. methyltransferase activity assays were used to...
Aim The purpose of this study was to explore the treatment and prognosis head neck rhabdomyosarcoma (RMS) in adults. Methods Fifty-nine patients with RMS adults (AHNRMS) treated one institution were selected. Multivariate analysis used evaluate various variables related overall survival (OS). Results estimated 5-year OS 36%. rate cervical lymph node (CLN) involvement 28%. Patients embryonic who underwent chemotherapy enjoyed a favorable outcome according multivariate (P = 0.047). Local...
Abstract Motivation: Many evolutionarily distant, but functionally meaningful links between proteins come to light through comparison of spatial structures. Most programs that assess structural similarity compare two each other and find regions in common them. Structural classification experts look for a particular motif instead. Programs base scores on superposition or closeness either Cartesian coordinates inter-residue contacts. Experts pay more attention the general orientation main...
Primary nuclear protein in testis (NUT) carcinoma is a rare malignant tumor originating from the salivary glands that usually occurs midline structures, such as head and neck, has been identified young patients. Progression of NUT rapid, there high degree invasion. The median survival time patients 6 to 9 months, 80% die within 1 year after diagnosis.This case report summarizes treatment 36-year-old male patient with right parotid gland. overall was 2 years. We also discuss applications...
Numerous studies compared the effectiveness of various formats video-based teaching, yet their focus has primarily been on relatively straightforward content, such as concepts and basic procedures. Research teaching complex content through different videos remains limited. This study addresses this gap by conducting a well-controlled comparison between recorded video narrated animation in context physics problem-solving, challenging area with easily measurable difficulty levels. The employed...
Ting He, Yi Zhong, Hongliang Li, Fei Jiang, Haobing Cai, Huan Yang, Song Ouyang, Weifan Yin, Xiaohua Dong, Qiuming Zeng
The main purpose of this study was to establish an ideal arrhythmia model using isoproterenol and explore its mechanism.Fifty healthy male SD rats were randomly divided into the following groups: control (CON), subcutaneous injection (SC; 5 mg/kg ISO for 2 consecutive days), intraperitoneal (IP; + 1 (5 by SC days then 3 IP day), 6 day). Electrocardiograms (ECGs) recorded a BL-420F system, pathological changes in myocardial tissue observed HE Masson staining. serum cTnI, TNF-α, IL-6, IL-1β...
Connexin 43 (Cx43) is a critical gene for maintaining myocardial homeostasis. Interestingly, Cx43 and stress-induced phosphoprotein 1 (STIP1) were recorded to be lowly expressed in ischemia/reperfusion (I/R). However, their impacts on reperfusion arrhythmia (RA) remain explored. Our study aimed find out the related underlying mechanisms.After establishment of an isolated heart model through Langendorff perfusion, rate, conduction activation time, velocity, direction left ventricle evaluated,...
This study was a randomized, double-blind, placebo-controlled to evaluate the safety and viral shedding of live attenuated influenza vaccine (LAIV) in Chinese healthy juveniles adults. A total 80 Eligible volunteers were divided into two age groups (≥18 3-17 years old). Volunteers randomly equally assigned experimental group by ratio 3:1 each group. Vaccination carried out steps. Totally, 34 (56.67%) adverse events 24 (40.00%) reactions LAIV reported. Most grade 1 2, incidence that 3 5%. The...
The incidence rates of non-alcoholic fatty liver disease (NAFLD) are increasing as a result lifestyle modifications, particularly dietary alterations. So, we investigated that diet intervention may be potential strategy to prevent or reduce NAFLD. NAFLD mice models were established by fed with high-fat (HFD) for 13 weeks. In the prevention trial and trial, resveratrol (RSV) was given study underlying protective effects. Hydroxypropyl-β-Cyclodextrin (HBC) embedding significantly increased...
e18046 Background: In the traditional chemotherapy paradigm, Surgical resection was tailored to tumor's pre-treatment dimensions. Neoadjuvant immunochemotherapy has demonstrated higher remission rates and more profound tumor regression, suggest a substantial reduction in necessary surgical margins. Hence, reducing extent following neoadjuvant could maintain treatment efficacy while conserving critical organ functionality. Methods: This single-center, single-arm Phase II clinical trial...
Soil salinity and alkalinity present a serious threat to global agriculture.The objective of this study is elucidate candidate genes associated with salt stresses in maize plant tissues through the utilization transcriptome transgene methods.Specifically, 8723 P138 cultivars were employed as salt-tolerant salt-sensitive materials, respectively.To verify tolerance materials screen best stress experimental concentration, different concentrations treatment carried out.Then, analysis was...
Objective Myeloma-related bone disease (MBD) is one of the most common complications multiple myeloma (MM). This study aims to investigate correlation between serum metabolism indexes (BMIs), clinical characteristics and prognosis newly diagnosed MM (NDMM) patients.
Abstract Students’ success in physics problem-solving extends beyond conceptual knowledge of physics, relying significantly on their mathematics skills. Understanding the specific contributions different skills to can offer valuable insights for enhancing education. Yet such studies are rare, particularly at high school level. This study addresses underexplored area this topic secondary education by investigating associations between performance using a robust methodological framework. We...