A5021490163- Plant and Fungal Interactions Research
- Bioenergy crop production and management
- Biofuel production and bioconversion
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Pancreatic and Hepatic Oncology Research
- Genetic Associations and Epidemiology
- Neuroscience and Neuropharmacology Research
- Gastric Cancer Management and Outcomes
- Genomics and Rare Diseases
- Epilepsy research and treatment
- Chromosomal and Genetic Variations
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes and associated disorders
- Genomic variations and chromosomal abnormalities
- Tracheal and airway disorders
- Optical Systems and Laser Technology
- Plant nutrient uptake and metabolism
- Cardiomyopathy and Myosin Studies
- Monoclonal and Polyclonal Antibodies Research
Shanghai Power Equipment Research Institute
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Shandong First Medical University
2024
Shandong Provincial Hospital
2024
State Administration of Foreign Exchange
2023
Yangzhou University
2019-2020
University of Ottawa
2018
Chinese Academy of Sciences
2014-2017
University of Chinese Academy of Sciences
2015-2017
Institute of Botany
2014-2017
Abstract Post-transcriptional modifications of RNA, such as RNA methylation, can epigenetically regulate behavior, for instance learning and memory. However, it is unclear whether methylation plays a critical role in the pathophysiology major depression disorder (MDD). Here, we report that expression fat mass obesity associated gene (FTO), an demethylase, downregulated hippocampus patients with MDD mouse models depression. Suppressing Fto results depression-like behaviors adult mice, whereas...
Major depressive disorder (MDD) is a prevalent and devastating mental illness. To date, the diagnosis of MDD largely dependent on clinical interviews questionnaires still lacks reliable biomarker. DNA methylation has stable reversible nature likely associated with course therapeutic efficacy complex diseases, which may play an important role in etiology disease. Here, we identified validated biomarker for from four independent cohorts Chinese Han population. First, integrated analysis...
Long non-coding RNA (lncRNA) is a class of with important regulatory roles in biological process organisms. The systematic comparison lncRNAs protein coding mRNAs population expression and their response to environmental change are still poorly understood. Here we identified 17,610 calculated levels based on RNA-seq 80 individuals Miscanthus lutarioriparius from two environments, the nearly native habitats transplanted field, respectively. LncRNAs had significantly higher diversity lower...
Abstract The development of second‐generation energy crops on marginal land relies the identification plants with suitable physiological properties. In this study, we measured and compared leaf photosynthesis water use efficiency 22 populations from three M iscanthus species, . lutarioriparius , sacchariflorus sinensis planted in two experimental fields located Qingyang Gansu Province ( QG ) Jiangxia Hubei JH C hina. is L oess P lateau, one world's most seriously eroded regions particularly...
Abstract Expression variation plays an important role in plant adaptation, but little is known about the factors impacting expression when population adapts to changing environment. We used RNA-seq data from 80 individuals 14 Miscanthus lutarioriparius populations, which were transplanted into a harsh environment native habitat, investigate level, diversity and genetic for genes expressed both environments. The level of with lower or without SNP tended be more changeable new environment,...
Abstract Miscanthus lutarioriparius is an endemic species that grows along the middle and lower reaches of Yangtze River a valuable source germplasm for development second‐generation energy crops. The plant propagates via seeds, stem nodes, rhizomes shows high phenotypic variation strong local adaptation. Here, we examined magnitude spatial distribution genetic in M. across its entire distributional range tested underlying factors shaped variation. Population analyses were conducted on 644...
While it is widely accepted that genetic diversity determines the potential of adaptation, role gene expression variation plays in adaptation remains poorly known. Here we show could have played a positive Miscanthus lutarioriparius. RNA-seq was conducted for 80 individuals species, with half planted energy crop domestication site and other control near native habitats. A leaf reference transcriptome consisting 18,503 high-quality transcripts obtained using pipeline developed de novo...
Understanding the genetic basis of water use efficiency (WUE) and its roles in plant adaptation to a drought environment is essential for production second-generation energy crops water-deficit marginal land. In this study, RNA-Seq WUE measurements were performed 78 individuals Miscanthus lutarioriparius grown two common gardens, one located warm wet Central China near native habitats species other semiarid Loess Plateau, domestication site crop. The field showed that M. location was...
The use of transcriptome data in the study population genetics a species can capture faint signals both genetic variation and expression provide broad picture species' genomic response to environmental conditions. In this study, we characterized diversity Miscanthus lutarioriparius by comparing more than 16,225 transcripts obtained from 78 individuals, belonging 10 populations distributed across entire geographic range. We only observed low level nucleotide (π = 0.000434) among these...
Abstract Given the growing need for biofuel production but lack of suitable land producing biomass feedstock, development stress‐tolerant energy crops will be increasingly important. We used comparative transcriptomics to reveal differential responses long‐term salt stress among five populations Miscanthus lutarioriparius grown in natural habitats and salinity experimental site. A total 59 genes were found potentially responsive high‐salinity conditions shared by populations, including those...
As a promising candidate for the second-generation C4 energy crop, Miscanthus lutarioriparius has well acclimated to water-limited and high-light Loess Plateau in China by improving photosynthesis rate water use efficiency (WUE) compared its native habitat along Yangtze River. Photosynthetic genes were demonstrated as one major category of underlying physiological superiority. To further study how photosynthetic interact improve acclimation potential M. lutarioriparius, population expression...
The relative risk of GWAS-confirmed loci strongly associated with schizophrenia may be underestimated due to the decay linkage disequilibrium between index SNPs and causal variants. This study is aimed investigate schizophrenia-associated signals detected in 1q24-25 region order identify a variant LD GWAS SNPs, potential biological functions gene.Re-genotyping analysis was performed that harbors three (rs10489202, rs11586522, rs6670165) total 9801 case-control subjects Chinese Han origin....
Microtia is a congenital malformation characterized by small, abnormally shaped auricle (pinna) ranging in severity. Congenital heart defect (CHD) one of the comorbid anomalies with microtia. However, genetic basis co-existence microtia and CHD remains unclear. Copy number variations (CNVs) 22q11.2 contribute significantly to CHD, respectively, thus suggesting possible shared cause embedded this genomic region. In study, 19 sporadic patients as well nuclear family, were enrolled for...
Adaptation is a characteristic that enhances the survival or reproduction of organisms; selection critical process leading to adaptive evolution. Therefore, detecting important in studying evolutionary biology. Changes allele frequency are fundamental The entire genes at genomic scale more intensive and precise for analyzing effects, compared with simple sequence repeat single nucleotide polymorphism (SNP) alleles from nuclear gene fragments. Here, we analyzed 29,094 SNPs derived 80...
Our retrospective study assessed the efficacy and safety of irinotecan plus raltitrexed in esophageal squamous cell cancer (ESCC) patients who were previously treated with multiple systemic therapies. Between January 2016 December 2018, records 38 ESCC underwent chemotherapy after at least one line reviewed. Efficacy assessment was performed every two cycles according to RECIST version 1.1. A total 95 administered, median course 3 (range 2-6). There no treatment-related death. Nine had...