A5088126655- Fibroblast Growth Factor Research
- Diabetes Treatment and Management
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Menopause: Health Impacts and Treatments
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Biochemical effects in animals
- Pancreatic function and diabetes
- Cancer-related cognitive impairment studies
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Estrogen and related hormone effects
- Neurological Disease Mechanisms and Treatments
- Physical Activity and Health
- Long-Term Effects of COVID-19
- Cardiovascular and exercise physiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Biomarkers in Disease Prognosis
- Salivary Gland Disorders and Functions
- Cardiovascular Function and Risk Factors
- Dietary Effects on Health
- Neuropeptides and Animal Physiology
- Advanced Glycation End Products research
Chiang Mai University
2015-2024
German Institute of Human Nutrition
2018
Thailand Center of Excellence in Physics
2015
Sodium-glucose cotransporter 2 inhibitor (SGLT2-i) effects on cardiac ischemia/reperfusion (I/R) injury are unclear. Unlike SGLT2-i, dipeptidyl peptidase 4 inhibitors (DPP4-i) have shown effective cardioprotection in I/R injury. We aimed to investigate whether SGLT2-i reduces myocardial dysfunction and a greater extent than DPP4-i obese insulin-resistant rats with/without The high-fat (HF) diet-induced were divided into groups received the following treatments for 28 days: vehicle (HFV);...
Abstract Background Postmenopausal women with obesity are markedly at risk of cognitive impairment and several health issues. Emerging evidence demonstrated that both diet exercise, particularly physical-cognitive exercise involved in benefits. However, the comparative effect diet, combined interventions postmenopausal on cognition cardiometabolic is still lacking. Identifying effective promotion program understanding changes linking these to would have important medical implications. This...
Fibroblast growth factor 21 (FGF21) acts as a metabolic regulator and exerts cardioprotective effects. However, the effects of long-term FGF21 administration on heart under FGF21-resistant condition in obese, insulin-resistant rats have not been investigated. We hypothesized that reduces resistance insulin attenuates cardiac dysfunction rats.Eighteen were fed either normal diet (n = 6) or high-fat (HFD; n 12) for 12 weeks. Then, HFD group divided into two subgroups 6 per subgroup) received...
Mitochondrial dysfunction is usually associated with various metabolic disorders and ageing. However, salutary effects in response to mild mitochondrial perturbations have been reported multiple organisms, whereas molecular regulators of cell-autonomous stress responses remain elusive. We addressed this question by asking whether the nuclear factor erythroid-derived-like 2 (Nrf2), a transcription master regulator cellular redox status involved adaptive physiological including muscle...
Brain mitochondrial dysfunction has been demonstrated in diabetic animals with neurodegeneration. Protocatechuic acid (PCA), a major metabolite of anthocyanin, shown to exert glycemic control and oxidative stress reduction the heart. However, its effects on function brain under condition have never investigated. We found that PCA exerted control, attenuates dysfunction, contributes prevention rats.
Cardiac function was markedly compromised in obese insulin-resistant and estrogen-deprived rats. Metformin dipeptidyl peptidase-4 inhibitor (vildagliptin) were reported to improve cardiac Their effects on the heart under conditions are, however, unknown. Therefore, of metformin, vildagliptin, estrogen female rats investigated.Bilateral ovariectomized (n = 48) divided be fed with either a normal diet (ND) or high-fat (HFD) for 12 weeks. Then, both ND- HFD-fed groups subdivided receive...
Abstract Dipeptidyl peptidase-4 (DDP-4) inhibitors and energy restriction (ER) are widely used to treat insulin resistance type 2 diabetes mellitus. However, the effects of ER or combination with vildagliptin on brain sensitivity, mitochondrial function, hippocampal synaptic plasticity cognitive function in obese insulin-resistant rats have never been investigated. We hypothesised that DDP-4 inhibitor exerts better efficacy than alone improving cognition male by restoring plasticity. A total...
Abstract Increased fibroblast growth factor 21 (FGF21) levels have been found in patients with metabolic syndrome (MetS). MetS is also associated cognitive decline. However, the correlation between FGF21 and decline elderly nonelderly has not investigated. 116 non-elderly (age <65 years old) 96 (≥65 were enrolled. Blood samples for collected from all participants after 12-hour fasting. Cognitive function was assessed using Montreal assessment (MoCA) test. The MoCA score negatively age...
Long-term consumption of a high-fat diet (HFD) causes not only obese-insulin resistance, but is also associated with mitochondrial dysfunction in several organs. However, the effect resistance on salivary glands has been investigated. We hypothesized that induced by HFD impaired gland function reducing salivation, increasing inflammation, and fibrosis, as well impairing calcium transient signaling. Male Wistar rats (200-220 g) were fed either ND or an (n = 8/group) for 16 weeks. At end week...
Background: Poor cardiorespiratory fitness poses the highest risk of mortality. Long-COVID-19 survivors exhibit a reduced (CRF). While exercise rehabilitation, such as cardiopulmonary exercise, is used for long-COVID-19 survivors, effects on CRF in this population remain inconclusive. In study, we aim to systematically summarise and synthesise whether rehabilitation improves among survivors. Methods: A comprehensive search was performed through PubMed, CINAHL, Embase, Scopus, Cochrane...
Cardiac ischemia-reperfusion injury (I/R) caused an oxidative burst, increased beta-amyloid production, and decreased dendritic spine density in the brain. However, effect of cardiac I/R brain estrogen-deprived rats who were or not obese have been investigated. Moreover, benefits estrogen dipeptidyl peptidase-4 (DDP-4) inhibitor therapies those conditions never determined. We hypothesized that aggravates pathology rats, to a greater extent when compared with lean treatment either DPP-4...
Summary Aims Comparative efficacy between fibroblast growth factor 21 (FGF21) and vildagliptin on metabolic regulation, cardiac mitochondrial function, heart rate variability (HRV), left ventricular (LV) function is not known. We hypothesized that FGF21 share a similar in improving these parameters high fat diet (HFD)‐induced obese‐insulin resistant rats. Methods Twenty‐four male Wistar rats were fed with either normal (ND) or HFD for 12 weeks. Then, ND received vehicle (NDV). Rats the group...
Obese-insulin resistance following chronic high-fat diet consumption led to cognitive decline through several mechanisms. Moreover, sex hormone deprivation, including estrogen and testosterone, could be a causative factor in inducing decline. However, comparative studies on the effects of hormone-deprivation brain are still lacking. Adult Wistar rats from both genders were conducted sham operations or orchiectomies/ovariectomies given normal for 4, 8, 12 weeks. Blood was collected determine...
Physical inactivity and a decline in cardiorespiratory fitness (CRF) are well-known risk factors for cardiovascular disease. Furthermore, evidence suggests correlation between obesity diminished CRF level. However, the influence of physical activity (PA) on level obese young adults remains unclear. The aim this study is to compare performance six-minute walk test (6MWT) physically active inactive aged 18-25 years. Fifty-six participants were included classified into two groups based their...