A5026142449- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Biochemical effects in animals
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Antioxidants, Aging, Portulaca oleracea
- Neuropeptides and Animal Physiology
- Alzheimer's disease research and treatments
- Lipoproteins and Cardiovascular Health
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Gut microbiota and health
- Phytoestrogen effects and research
Chiang Mai University
2015-2024
Thailand Center of Excellence in Physics
2012-2015
Chronic high-fat diet (HFD) consumption caused not only obese-insulin resistance, but also cognitive decline and microglial hyperactivity. Modified gut microbiota by prebiotics probiotics improved resistance. However, the effects of prebiotics, probiotics, synbiotics on cognition activity in an resistant condition have yet been investigated. We aimed to evaluate effect prebiotic (Xyloolidosaccharide), probiotic (Lactobacillus paracasei HII01), or male rats induced a HFD.Male Wistar were fed...
We previously demonstrated that a high-fat diet (HFD) consumption can cause not only peripheral insulin resistance, but also neuronal resistance. Moreover, the of an HFD has been shown to mitochondrial dysfunction in both skeletal muscle and liver. Rosiglitazone, peroxizome proliferator-activated receptor-γ ligand, is drug used treat type 2 diabetes mellitus. Recent studies suggested rosiglitazone improve learning memory human animal models. However, effects on resistance brain mitochondria...
Abstract High‐fat diet ( HFD ) consumption has been demonstrated to cause peripheral and neuronal insulin resistance, brain mitochondrial dysfunction in rats. Although the dipeptidyl peptidase‐4 inhibitor, vildagliptin, is known improve sensitivity, its effects on resistance caused by a are unknown. We tested hypothesis that vildagliptin prevents dysfunction, learning memory deficit . Male rats were divided into two groups receive either or normal ND for 12 weeks, after which each group fed...
Previous studies showed that 12 weeks of high-fat diet (HFD) consumption caused not only prediabetes but also cognitive decline and brain pathologies. Recently, necrostatin-1 (nec-1), a necroptosis inhibitor, beneficial effects in against stroke. However, the comparative nec-1 metformin on cognition pathologies have been investigated. We hypothesized equally attenuated prediabetic rats. Rats (n = 32) were fed with either normal (ND) or HFD for 20 weeks. At week 13, ND-fed rats given vehicle...
The endogenous DNA damage triggering an aging progression in the elderly is prevented youth, probably by naturally occurring gaps. Decreased gaps are found during chronological yeast. So we named "Youth-DNA-GAPs." hidden histone deacetylation to prevent break response and were also reduced cells lacking either high-mobility group box (HMGB) or NAD-dependent deacetylase, SIR2. A reduction results shearing strands decreasing cell viability. Here, show roles of genomic stability prevention...
Abstract Aim The study hypothesized that testosterone deprivation aggravates cognitive decline in obesity through increasing oxidative stress, glial activation, and apoptosis. Methods Male Wistar rats (n = 24) were fed with either normal‐diet (ND) or high‐fat diet (HFD) for 24 weeks. At week 13, ND‐fed HFD‐fed randomly assigned to two subgroups receive a sham‐operation bilateral‐orchiectomy (ORX). Rats evaluated metabolic parameters cognition at 4, 8, 12 weeks after the operation. end of...
Background: High-fat diet (HFD) consumption induced gut dysbiosis, inflammation, obese-insulin resistance. Perilla seed oil (PSO) is a rich source of omega-3 polyunsaturated fatty acids with health promotional effects. However, the effects PSO on microbiota/inflammation and metabolic disturbance in HFD-induced obesity have not been investigated. Therefore, we aimed to compare different doses metformin microbiota/inflammation, parameters HFD-fed rats. Methods: Thirty-six male Wistar rats were...