A5059611621- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Phosphodiesterase function and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Biological Activities
- Ginger and Zingiberaceae research
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Traditional and Medicinal Uses of Annonaceae
- Phytochemicals and Medicinal Plants
- Biological and pharmacological studies of plants
- Computational Drug Discovery Methods
- Phytochemical Studies and Bioactivities
- Chromatography in Natural Products
- Hair Growth and Disorders
- melanin and skin pigmentation
- Drug-Induced Hepatotoxicity and Protection
- Alzheimer's disease research and treatments
- Piperaceae Chemical and Biological Studies
- Skin Protection and Aging
- Oral microbiology and periodontitis research
Naresuan University
2016-2025
Pharmac
2008-2022
Naresuan University Hospital
2008-2022
Airlangga University
2020
Pharmaceutical Biotechnology (Czechia)
2015-2019
Chulalongkorn University
2008-2015
Leiden University
1999-2001
Mass spectrometry (MS) offers unrivalled sensitivity for the metabolite profiling of complex biological matrices encountered in natural products (NP) research. The massive and sets spectral data generated by such platforms require computational approaches their interpretation. Within approaches, annotation automatically links to candidate structures via a score, which is usually established between acquired experimental or theoretical databases (DB). This process leads various each MS...
Cerebral ischemia is known to produce brain damage and related behavioral deficits including memory. Recently, accumulating lines of evidence showed that dietary enrichment with nutritional antioxidants could reduce improve cognitive function. In this study, possible protective effect Zingiber officinale, a medicinal plant reputed for neuroprotective against oxidative stress-related damage, on memory deficit induced by focal cerebral was elucidated. Male adult Wistar rats were administrated...
At present, the scientific evidence concerning effect of Bacopa monnieri on brain activity together with working memory is less available. Therefore, we aimed to determine B. attention, cognitive processing, memory, and cholinergic monoaminergic functions in healthy elderly. A randomized double-blind placebo-controlled design was utilized. Sixty elderly subjects (mean age 62.62 years; SD 6.46), consisting 23 males 37 females, received either a standardized extract (300 600 mg) or placebo...
This study aims to investigate the biological activities related hair loss of Equisetum debile extracts, including 5α-reductase inhibition, interleukin-6 (IL-6) secretion reduction, and anti-oxidation. E. extracts were obtained by maceration in various solvents. Crude extract (CE) was 95% ethanol. Chlorophyll-free (CF) CE which chlorophyll has been removed electrocoagulation. Hexane (HE), ethyl acetate (EA), ethanolic (ET) fraction from hexane, acetate, ethanol, respectively. The...
Abstract Acetylcholinesterase (AChE) inhibitors have lately gained interest as potential drugs in the treatment of Alzheimer's disease. Three AChE were isolated from tubers a Thai medicinal plant, Stephania venosa (Bl) Spreng. They identified quaternary protoberberine alkaloids, stepharanine, cyclanoline and N-methyl stepholidine. expressed inhibitory activity on with IC50 values (concentration that caused 50% inhibition activity) 14.1K ± 0.81, 9.23 3.47 31.30 3.67 μM, respectively. The...
Acetylcholinesterase-inhibiting activity of marinoquinoline A (1), a new pyrroloquinoline from novel species marine gliding bacterium Rapidithrix thailandica, was assessed (IC50 4.9 μM). Two related pyrrole derivatives, 3-(2'-aminophenyl)-pyrrole (3) and 2,2-dimethyl-pyrrolo-1,2-dihydroquinoline (4), were also isolated two other strains R. thailandica. The isolation 3 natural source is reported here for the first time. Compound 4 proposed to be an artifact derived 3. compounds virtually...
Introduction: Cannabidiol (CBD), cannabinol (CBN), and Δ9-tetrahydrocannabinol (Δ9-THC) are major cannabinoids in cannabis resin products. The kinetic of the chemical reaction is important for product development storage. A few reports available literature on rate CBD Δ9-THC degradation, CBN formation dried solutions various pH. Materials Methods: Thermal degradation CBD, Δ9-THC, was studied at 50°C, 60°C, 70°C, 80°C resin. effect pH temperature transformation solution also examined 2, 4, 6,...
Abstract Androgenic alopecia is a common type of hair loss, usually caused by testosterone metabolism generating dihydrotestosterone and follicular micro-inflammation. These processes induce dermal papilla cells to undergo apoptosis. Currently approved effective medications for are Finasteride, an oral 5α-reductase inhibitor, Minoxidil, topical growth promoter, Diclofenac, anti-inflammatory agent, all which, however, have several adverse side effects. In our study, we showed the bioactivity...
The leaf extract of Tectona grandis L.f. has shown potential as a 5α-reductase inhibitor, with two bioactive markers, namely (+)-eperua-8,13-dien-15-oic acid (1) and (+)-eperua-7,13-dien-15-oic (2), used for standardization. purpose this research was to investigate the in vitro skin penetration behavior 1 2 T. ethanolic solution ready-to-use propylene glycol (PG), secondly, determine their physicochemical properties, including partition coefficients solubility. appropriate vehicle study...