A5090308767- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Head and Neck Cancer Studies
- CRISPR and Genetic Engineering
- Tumors and Oncological Cases
- RNA modifications and cancer
- Fungal Biology and Applications
- Genomics, phytochemicals, and oxidative stress
- Chromatography in Natural Products
- Seaweed-derived Bioactive Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Telomeres, Telomerase, and Senescence
- RNA Interference and Gene Delivery
Chulalongkorn University
2015-2023
The endogenous DNA damage triggering an aging progression in the elderly is prevented youth, probably by naturally occurring gaps. Decreased gaps are found during chronological yeast. So we named "Youth-DNA-GAPs." hidden histone deacetylation to prevent break response and were also reduced cells lacking either high-mobility group box (HMGB) or NAD-dependent deacetylase, SIR2. A reduction results shearing strands decreasing cell viability. Here, show roles of genomic stability prevention...
DNA methylation of specific genome locations contributes to the distinct functions multicellular organisms. can be governed by RNA-dependent (RdDM). RdDM is carried out endogenous small-RNA-guided epigenomic editing complexes that add a methyl group precise location. In plants, Argonaute 4 (AGO4) protein one main catalytic components involved in RdDM. Although siRNA or shRNA has been shown able guide human cells, AGO protein-regulated humans not yet evaluated. This study aimed identify key...
Human papillomavirus (HPV) oncoproteins drive distinctive promoter methylation patterns in cancer. However, the underlying mechanism remains to be elucidated. Cyclin A1 (CCNA1) is strongly associated with HPV-associated CCNA1 found cervical cancers, as well head and neck squamous cell Numerous pieces of evidence suggest that E7 may methylation. First, methylated HPV-positive epithelial lesions after transformation. Second, at a high level when HPV integrated into human genome. Finally, has...
Cervical cancer is the most fourth common in women worldwide. The E6 and E7 high-risk human papillomavirus (HPV) types are main cause of this cancer. Several studies have revealed that promoter methylation tumor suppressor genes induced by HPV E7. Recently, it was found HPV16‑E7 DNA methyltransferase 1 complex could bind at cyclin A1 (CCNA1) promoter, resulting CCNA1 methylation. Therefore, there a need to study other for which may induce present investigated whether cell adhesion molecule...
The incidence of oral squamous cell carcinoma (OSCC) continues to increase each year. Clinical examination and biopsy usually detect OSCC at an advanced stage that is difficult treat, leading poor prognosis. DNA methylation pattern tissue specific has emerged as a biomarker for the detection cancers origin. Herein, we aimed discover novel site-specific marker OSCC.We selected datasets analyzed using IlluminaHumanMethylation27 BeadChip from Gene Expression Omnibus repository National Center...
Abstract Background Although the prevalence of breast cancer (BC) has been reduced in recent years, proficient therapeutic regimens should be further investigated with aim reducing mortality rate. To obtain more effective treatment, present study aimed to observe effects PL synergistically combined Smilax corbularia and S. glabra extracts (PSS) on BC cell lines, MCF7, T47D, MDA-MB-231, MDA-MB-468. Methods The half-maximal inhibition (IC 50 ) concentrations PSS were determined a dose-...
Overexpression of the E7 gene human papillomavirus (HPV) type 16 is one primary causes cervical cancer. The protein can bind with DNA methyltransferase I and induce methylation tumor suppressor genes, such as cyclin‑A1 (<em>CCNA1</em>), leading to suppression their expression, thus, cancer progression. In present study, confirmation methylation‑related expression chorionic gonadotropin subunit 3 (<em>CGB3</em>) nucleolar 56 (<em>NOP56</em>) genes in 5‑Azacytidine (5'‑aza)‑treated...