A5003962079- DNA Repair Mechanisms
- Carcinogens and Genotoxicity Assessment
- Microtubule and mitosis dynamics
- PARP inhibition in cancer therapy
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Microfluidic and Capillary Electrophoresis Applications
- Polymer Nanocomposite Synthesis and Irradiation
- Wound Healing and Treatments
- Effects of Radiation Exposure
- Radiation Detection and Scintillator Technologies
- Genomics, phytochemicals, and oxidative stress
- Radiation Effects in Electronics
- Genomics and Chromatin Dynamics
- Telomeres, Telomerase, and Senescence
- Protein purification and stability
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Vector-borne infectious diseases
- Neuroblastoma Research and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mesenchymal stem cell research
- Viral Infections and Vectors
- Cancer therapeutics and mechanisms
- Advanced Radiotherapy Techniques
Mahidol University
2021-2022
University of Medical Sciences and Technology
2021
Bangkok University
2021
Tokyo Institute of Technology
2013-2021
Chulalongkorn University
2010
The endogenous DNA damage triggering an aging progression in the elderly is prevented youth, probably by naturally occurring gaps. Decreased gaps are found during chronological yeast. So we named "Youth-DNA-GAPs." hidden histone deacetylation to prevent break response and were also reduced cells lacking either high-mobility group box (HMGB) or NAD-dependent deacetylase, SIR2. A reduction results shearing strands decreasing cell viability. Here, show roles of genomic stability prevention...
Alu (B1 in rodents) hypomethylation, commonly found diabetes mellitus patients, increases DNA damage and, consequently, delays the healing process. siRNA methylation, reduces damage, and promotes cell proliferation. Aim: To explore whether B1 treatment restores resulting a reduction acceleration of process diabetic rat wounds. Methods: We generated splinted-excisional wounds streptozotocin (STZ)-induced type I model treated with siRNA/Ca-P nanoparticles to generate de novo methylation...
A quick, reliable, and reproducible biological assay to distinguish individuals with possible life-threatening risk following radiological or nuclear incidents remains a quest in biodosimetry. In this paper, we examined the use of γ-H2AX as an early dose estimation for rapid triage based on both flow cytometry image analyses. experiment, whole blood from 11 donors was irradiated ex vivo inside water phantom by gamma rays Co-60 at 0.51 Gy/min. After lysis red cells, white cells were collected...
Abstract DNA double-strand breaks (DSBs) are the most lethal form of damage to cells from irradiation. γ-H2AX (phosphorylated H2AX histone variant) has become one reliable and sensitive biomarkers DSBs. However, foci assay still limitations in time consumed for manual scoring possible variability between scorers. This study proposed a novel automated method using deep convolutional neural network based on You-Only-Look-Once (YOLO) algorithm quantify peripheral blood samples. FociRad,...
A colorimetric liquid sensor based on a poly(vinyl alcohol)/silver nanoparticle (PVA/AgNPs) hybrid nanomaterial was developed for gamma radiation in the range of 0−100 Gy. In this study, rays (Cobalt-60 source) triggered aggregation AgNPs PVA/silver nitrate (AgNO3) solution. The color solution visibly changed from colorless to dark yellow. Absorption spectra PVA/AgNPs were analyzed by UV-Vis spectrophotometry 350−800 nm. Important parameters, such as pH and AgNO3 concentration optimized....
Abstract Non-homologous end joining is one of the main pathways for DNA double-strand break (DSB) repair and also implicated in V(D)J recombination immune system. Therefore, mutations non-homologous end-joining (NHEJ) proteins were found to be associated with immunodeficiency human as well model animals. Several patients XRCC4 reported exhibit microcephaly growth defects, but unexpectedly showed normal function. Here, evaluate functionality these disease-associated terms radiosensitivity, we...
Iodine-131 meta-iodobenzylguanidine (131I-mIBG) has been utilized as a standard treatment to minimize adverse side effects by targeting therapies bind the norepinephrine transporter (NET) expressed on 90% of neuroblastoma cells. However, only minority patients who receive 131I-mIBG radiotherapy have clinical responses, and these are usually not curative. In this study, novel ligand-conjugated gold nanoparticles (GNPs) based mIBG were synthesized evaluated biologically with cells in vitro. To...
Attempt to improve latex immunoagglutination assay, a rapid method in medical diagnostics, reporting as quantitative results was interested this study by using microfluidic device. Sensitized produced physical adsorption of human polyclonal IgG antibody Plasmodium falciparum malaria parasite onto carboxylated polystyrene particle. Conventional agglutination assay firstly performed verify specific interaction on the bead surface versus antigen plasma. The agglutinate size around 30 µm...