A5082830311- Wound Healing and Treatments
- Pressure Ulcer Prevention and Management
- Garlic and Onion Studies
- NF-κB Signaling Pathways
- Antioxidants, Aging, Portulaca oleracea
- Telomeres, Telomerase, and Senescence
- Heat shock proteins research
- Phytochemical compounds biological activities
- Tissue Engineering and Regenerative Medicine
- Amino Acid Enzymes and Metabolism
- Mesenchymal stem cell research
- Burn Injury Management and Outcomes
- Genomics, phytochemicals, and oxidative stress
- Digestive system and related health
- Neuroinflammation and Neurodegeneration Mechanisms
Chulalongkorn University
2022-2024
King Chulalongkorn Memorial Hospital
2022
Mahidol University
2021
The endogenous DNA damage triggering an aging progression in the elderly is prevented youth, probably by naturally occurring gaps. Decreased gaps are found during chronological yeast. So we named "Youth-DNA-GAPs." hidden histone deacetylation to prevent break response and were also reduced cells lacking either high-mobility group box (HMGB) or NAD-dependent deacetylase, SIR2. A reduction results shearing strands decreasing cell viability. Here, show roles of genomic stability prevention...
Alu (B1 in rodents) hypomethylation, commonly found diabetes mellitus patients, increases DNA damage and, consequently, delays the healing process. siRNA methylation, reduces damage, and promotes cell proliferation. Aim: To explore whether B1 treatment restores resulting a reduction acceleration of process diabetic rat wounds. Methods: We generated splinted-excisional wounds streptozotocin (STZ)-induced type I model treated with siRNA/Ca-P nanoparticles to generate de novo methylation...
Kaab Dum, a prominent indigenous rice variety cultivated in the Pak Phanang Basin of Nakhon Si Thammarat, Thailand, is focus our study. We investigate therapeutic potential Dum extract context chronic wounds. Our research encompasses an examination nutritional compositions and chemical profiles extract. Additionally, we assess how affects wounds TGF-β-induced HaCaT cells. evaluation methods include detection cellular oxidative stress, endoplasmic reticulum (ER) wound healing assays, analysis...
Disability and mortality rates for renal failure are still increasing. DNA damage oxidative stress intoxication from body metabolism, high blood glucose, or the environment cause significant kidney damage. Recently, we reported that Box A of HMGB1 (Box A) acts as molecular scissors, producing gaps prevent in cell lines ultimately reverse aging phenotypes rat models. The present study aimed to demonstrate potency preventing D-galactose (D-gal)-induced injury.
Colorectal cancer (CRC) is an aggressive malignancy. Critical mechanisms that support CRC progression include cell migration, invasion, metastasis, and angiogenesis, which associated with L1 adhesion molecule (L1CAM) nuclear factor-kappa B (NF-κB) signaling pathways. In this study, viability of HT-29 cells human umbilical vein endothelial (HUVECs) was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays, apoptosis investigated flow cytometry assays. migration...
Background/Aim: Breast cancer is the most prevalent form of among women worldwide, with a high mortality rate. While common cause breast death metastasis, there currently no potential treatment for patients at metastatic stage. The present study investigated using combination HSP90 and mTOR inhibitor in cell growth, migration, invasion. Materials Methods: Gene Expression Profiling Interactive Analysis (GEPIA) was used to investigate gene expression profiles. Western blot analysis...