A5063259639- Trace Elements in Health
- Regulation of Appetite and Obesity
- Iron Metabolism and Disorders
- Mitochondrial Function and Pathology
- Hemoglobinopathies and Related Disorders
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Dementia and Cognitive Impairment Research
- Cancer-related cognitive impairment studies
- Metabolism and Genetic Disorders
- Tryptophan and brain disorders
- Fibroblast Growth Factor Research
- Menopause: Health Impacts and Treatments
- Diabetes Management and Education
- Cancer, Stress, Anesthesia, and Immune Response
- Biochemical effects in animals
- Cardiac Ischemia and Reperfusion
- Folate and B Vitamins Research
- Pharmacological Effects and Toxicity Studies
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
Chiang Mai University
2016-2025
Excessive iron accumulation leads to toxicity in the brain; however underlying mechanism is unclear. We investigated effects of overload induced by high iron-diet consumption on brain mitochondrial function, synaptic plasticity and learning memory. Iron chelator (deferiprone) antioxidant (n-acetyl cysteine) iron-overload brains were also studied.Male Wistar rats fed either normal diet or for 12 weeks, after which each group treated with vehicle deferiprone (50 mg/kg) n-acetyl cysteine (100...
Iron overload in the heart can lead to iron-overload cardiomyopathy and cardiac arrhythmia. In past decades, growing evidence has suggested that mitochondrial dysfunction is associated with development of lethal arrhythmias. Despite these facts, effect iron on function still unclear. this study, we determined effects routes uptake. We tested hypothesis calcium uniporter (MCU) plays a major role for uptake under condition. Cardiac was assessed via determination swelling, reactive oxygen...
Abstract Aim Prolonged high‐fat diet (HFD) consumption has been shown to impair cognition and depression. The combined effects of HFD lipopolysaccharide (LPS) administration on those outcomes have never thoroughly investigated. This study investigated the LPS, consumption, a combination both conditions microglial dysfunction, morphological alterations, synaptic loss, cognitive depressive‐like behaviors. Methods Sixty‐four male Wistar rats were fed either normal (ND) or for 12 weeks, followed...
Iron chelators are used to treat iron overload cardiomyopathy patients. However, a direct comparison of the benefits three common (deferoxamine (DFO), deferiprone (DFP) and deferasirox (DFX)) or an antioxidant (N-acetyl cysteine (NAC)) with combined DFP NAC treatments on left ventricular (LV) function has not been investigated.Male Wistar rats were fed either normal diet high (HFe group) for 4 months. After 2 months, HFe-fed divided into 6 groups receive either: vehicle, DFO (25 mg/kg/day),...
Abstract Vagus nerve stimulation (VNS) therapy was shown to improve peripheral insulin sensitivity. However, the effects of chronic VNS on brain sensitivity, dendritic spine density, mitochondrial function, apoptosis and cognition in obese-insulin resistant subjects have never been investigated. Male Wistar rats (n = 24) were fed with either a normal diet 8) or HFD 16) for 12 weeks. At week 13, HFD-fed divided into 2 groups 8/group). Each group received sham an additional end treatment,...
Oxidative stress in the obese-insulin resistant condition has been shown to affect cognitive as well brain mitochondrial functions. Garlic extract exerted a potent antioxidant effect. However, effects of garlic on rats have never investigated. We hypothesized that improves function and induced by long-term high-fat diet (HFD) consumption. Male Wistar were fed either normal or HFD for 16 weeks (n = 24/group). At week 12, each dietary group received vehicle (250 500 mg·kg –1 ·day ) 28 days....
Brain mitochondrial dysfunction has been demonstrated in diabetic animals with neurodegeneration. Protocatechuic acid (PCA), a major metabolite of anthocyanin, shown to exert glycemic control and oxidative stress reduction the heart. However, its effects on function brain under condition have never investigated. We found that PCA exerted control, attenuates dysfunction, contributes prevention rats.
Abstract This quasi‐experimental study evaluated feasibility and preliminary efficacy of dementia‐preventive educational training intervention program based on the health belief model for improving perceived beliefs behaviors among people with type 2 diabetes mellitus. Two community hospitals 72 eligible participants were chosen from 12 local institutions using simple random sampling method. One hospital (22 patients) was allocated to intervention, other (23 control (using sampling). Primary...
Exogenous treatment of a neurotensin receptor 1 (NTR1) agonist exerted the neuroprotection in an obese and Alzheimer’s model. However, effects NTR1 modulation on peripheral/hippocampal impairment cognitive deficit following sustained HFD consumption are poorly understood. Forty rats received normal diet (ND) or for 16 weeks. At week 13, ND group vehicle ( n = 8). Thirty-two HFD-fed were randomized into four subgroups 8/subgroup) with vehicle, mg/kg agonist, NTR antagonist, combined (NTR1...
Abstract Increased fibroblast growth factor 21 (FGF21) levels have been found in patients with metabolic syndrome (MetS). MetS is also associated cognitive decline. However, the correlation between FGF21 and decline elderly nonelderly has not investigated. 116 non-elderly (age <65 years old) 96 (≥65 were enrolled. Blood samples for collected from all participants after 12-hour fasting. Cognitive function was assessed using Montreal assessment (MoCA) test. The MoCA score negatively age...