A5055084636- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Ischemia and Reperfusion
- Biochemical effects in animals
- Diet and metabolism studies
- Neurological Disease Mechanisms and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Alzheimer's disease research and treatments
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Hormonal and reproductive studies
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Cancer-related cognitive impairment studies
- Cancer Treatment and Pharmacology
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Erythropoietin and Anemia Treatment
- Vagus Nerve Stimulation Research
Chiang Mai University
2016-2025
Thailand Center of Excellence in Physics
2012-2018
Recent evidence has demonstrated that insulin resistance is related to the development of type 2 diabetes mellitus. Our previous study found high-fat diet (HFD) consumption caused not only peripheral and brain but also mitochondrial dysfunction cognitive impairment. Vildagliptin sitagliptin, dipeptidyl-peptidase-4 inhibitors, are recently developed anti-diabetic drugs. However, effects both drugs on behaviors function in HFD-induced insulin-resistant rats have yet been investigated. Sixty...
Abstract Background A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on the attenuation of hyperglycemia together with severity heart failure. However, effects acute dapagliflozin administration at time cardiac ischemia/reperfusion (I/R) injury are not established. Methods The function were investigated by treating I/R different points. Cardiac was instigated in forty-eight Wistar rats. These rats then split into 4 interventional groups: control, (SGLT2 inhibitor, 1...
Long-term high-fat diet (HFD) consumption has been shown to cause insulin resistance, which is characterized by hyperinsulinaemia with metabolic inflexibility. Insulin resistance associated cardiac sympathovagal imbalance, dysfunction and mitochondrial dysfunction. Dipeptidyl peptidase-4 (DPP-4) inhibitors, vildagliptin sitagliptin, are oral anti-diabetic drugs often prescribed in patients cardiovascular disease. Therefore, this study, we sought determine the effects of sitagliptin a murine...
Insulin resistance has been shown to be associated with cardiac sympathovagal imbalance, myocardial dysfunction, and mitochondrial dysfunction. Whereas metformin is a widely used antidiabetic drug improve insulin resistance, vildagliptin novel oral in group of dipeptidyl peptidase-4 inhibitors which its effect unclear. This study aimed determine the cardiovascular effects rats induced by high-fat diet. Male Wistar were fed either normal diet or (n =24 each) for 12 wk. Rats each divided into...
Background Obese-insulin resistance caused by long-term high-fat diet (HFD) consumption is associated with left ventricular (LV) dysfunction and increased risk of myocardial infarction. Metformin vildagliptin have been shown to exert cardioprotective effects. However, the effect these drugs on hearts under obese-insulin ischemia-reperfusion (I/R) injury unclear. We hypothesized that combined metformin provide better protective effects against I/R than monotherapy in resistant rats....
Background Cardiac ischemic/reperfusion (I/R) injury leads to brain damage. A new antihyperlipidemic drug is aimed at inhibiting PCSK 9 (proprotein convertase subtilisin/kexin type 9), a molecule first identified in neuronal apoptosis paradigm. Thus, the inhibitor ( 9i) may play role recovery following cardiac I/R insults. We hypothesize that 9i attenuates damage caused by via diminishing microglial/astrocytic hyperactivation, β-amyloid aggregation, and loss of dendritic spine. Methods...
Cognitive impairment has been reported in patients with myocardial infarction despite a successful reperfusion therapy. Several modes of cell death are involved brain damage during cardiac ischemia/reperfusion (I/R) injury. Although apoptosis, necroptosis, and ferroptosis inhibitors provided neuroprotection against cerebral I/R injury, the effects these on following injury have never investigated. We hypothesized that attenuate One-hundred twenty-six male rats were used: 6 assigned to sham...
Abstract Growing evidence demonstrated that cell death pathways including ferroptosis, apoptosis and necroptosis contribute to cardiac ischaemia/reperfusion (I/R) injury. We hypothesized differently myocardial damage during acute I/R Rats underwent or sham operation. I/R‐operated rats were divided into 4 groups: vehicle, (Z‐vad), ferroptosis (Fer‐1) (Nec‐1) inhibition. in each inhibitor group subdivided 3 different dose regimens: low, medium high. Infarct size, left ventricular (LV)...
Myocardial reperfusion via the re-canalization of occluded coronary arteries is gold standard for treatment acute myocardial infarction. However, itself can cause damage due to increased reactive oxygen species (ROS) production, a process known as ischemia/reperfusion (I/R) injury. Cardiac mitochondria are major organelle ROS production in heart. mitochondrial dysfunction caused by an increase cardiac arrhythmia incidence, infarct size, and dysfunction. Thus, preservation function promising...
Although coenzyme Q10 (CoQ10) supplementation has shown to reduce pain levels in chronic pain, the effects of CoQ10 on anxiety, brain activity, mitochondrial oxidative stress, antioxidants, and inflammation pregabalin-treated fibromyalgia (FM) patients have not clearly elucidated. We hypothesised that reduced better than pregabalin alone via reducing inflammation, increasing antioxidant FM patients. A double-blind randomised placebo-controlled trial was conducted. Eleven were enrolled with 2...
Previous studies showed that 12 weeks of high-fat diet (HFD) consumption caused not only prediabetes but also cognitive decline and brain pathologies. Recently, necrostatin-1 (nec-1), a necroptosis inhibitor, beneficial effects in against stroke. However, the comparative nec-1 metformin on cognition pathologies have been investigated. We hypothesized equally attenuated prediabetic rats. Rats (n = 32) were fed with either normal (ND) or HFD for 20 weeks. At week 13, ND-fed rats given vehicle...
Abstract Background We aimed to compare the changes in blood metabolomes and cardiac parameters following doxorubicin treatment HER2-positive HER2-negative breast cancer patients. Additionally, potential roles of as severity prognostic markers doxorubicin-induced cardiotoxicity were determined. Methods (n = 37) patients enrolled. Cardiac function assessment collection performed at baseline 2 weeks after completion all patients, well three months Blood obtained three-time points was processed...
ABSTRACT Patients with chronic kidney disease (CKD) are at increased risk of acute injury following exposure to contrast media. We evaluated the effect melatonin, a potent antioxidant, as protective strategy against contrast‐induced (CI‐AKI), focus on molecular mechanisms. randomized patients an eGFR < 60 mL/min/1.73 m 2 undergoing coronary angiography (CAG) into melatonin (10 mg twice daily) or placebo groups. Treatment started 48 h before CAG and continued for total 6 days. Peripheral...