A5004465732- Circadian rhythm and melatonin
- Cardiac Ischemia and Reperfusion
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
- Erythropoietin and Anemia Treatment
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Metabolism and Genetic Disorders
- Vagus Nerve Stimulation Research
- Ferroptosis and cancer prognosis
- Cardiac electrophysiology and arrhythmias
- Tryptophan and brain disorders
- Immune cells in cancer
- Free Radicals and Antioxidants
- Metabolism, Diabetes, and Cancer
- Immune Response and Inflammation
- Birth, Development, and Health
- Electron Spin Resonance Studies
- Coenzyme Q10 studies and effects
- Peroxisome Proliferator-Activated Receptors
- Alzheimer's disease research and treatments
Chiang Mai University
2018-2023
Cognitive impairment has been reported in patients with myocardial infarction despite a successful reperfusion therapy. Several modes of cell death are involved brain damage during cardiac ischemia/reperfusion (I/R) injury. Although apoptosis, necroptosis, and ferroptosis inhibitors provided neuroprotection against cerebral I/R injury, the effects these on following injury have never investigated. We hypothesized that attenuate One-hundred twenty-six male rats were used: 6 assigned to sham...
Previous studies reported the beneficial effects of pretreatment with melatonin on heart during cardiac ischemia/reperfusion (I/R) injury. However, given after ischemia, as well its comparative temporal are unknown. These include pretreatment, and at onset reperfusion. Also, association between receptors arrhythmias, mitochondrial function dynamics, autophagy, mitophagy I/R have not been investigated. We tested two major hypotheses in this study. Firstly, effect administration exerts...
High-fat diet (HFD) consumption induces prediabetes and left ventricular dysfunction through many pathways including cell death pathway like necroptosis. Although the benefit of necroptosis inhibitor (necrostatin-1 or Nec-1) in brain prediabetic rats was shown, effects Nec-1 on cardiac autonomic function, blood pressure, along with its mechanistic insight have not been investigated. Male Wistar were fed either a normal ( n = 8) HFD 24) for 12 weeks to induce prediabetes. Prediabetic randomly...
Acute myocardial infarction (AMI) leads to cardiac dysfunction and also causes brain pathology. The neuroprotective effects of erythropoietin (EPO), the hormone controlling production red blood cells, have been shown in case cerebral ischemic/reperfusion (I/R) injury. However, EPO on pathologies induced by I/R injury not investigated. We hypothesized that administration attenuates damage caused through decreasing peripheral oxidative stress, preserving microglial morphology, attenuating...
Abstract Background The number of obese people is increasing globally. Our previous studies showed that chronic high-fat diet (HFD) consumption led to obesity with peripheral insulin resistance, which was associated left ventricular (LV) dysfunction. Mechanistically, cardiac mitochondrial dysfunction and cell death are proposed as an underlying mechanism for LV in subjects. Recently, necroptosis defined a novel pathway, can be found various types diseases such myocardial ischaemia heart...
Abstract Background Chronic inflammation involves in the left ventricular (LV) dysfunction high-fat diet (HFD)-induced prediabetes, along with cardiac mitochondrial dysfunction. This involved an activation of myeloid differentiation factor 2 (MD2)/toll-like receptor 4 (TLR4) by lipopolysaccharide, leading to inflammatory cytokines production heart. MAC28 is a novel MD2 inhibitor, which had been shown provide effects against LPS-induced cytokine secretion from macrophages. However, potential...
Cardiac ischemia/reperfusion (I/R) injury is not only the major cause of cardiac dysfunction, but also leads to brain damage. It has been shown that blood barrier (BBB) breakdown, increased oxidative stress, apoptosis, beta-amyloid (Aβ) production, and mitochondrial dysfunction occurred following I/R injury. However, alteration dynamics investigated. The present study aims investigate alterations phosphorylation (OXPHOS) We hypothesize dynamic imbalance impaired respiration. Rats were...
Abstract Background Cardiac ischaemia/reperfusion (I/R) injury has been an economic and health burden worldwide. Previous studies have reported the beneficial effects of melatonin when given prior to cardiac ischaemia in animals with I/R injury. However, on hearts it is after or at onset reperfusion, which more relevant clinical setting, not known. Moreover, mechanisms responsible for potential benefits roles receptors heart during fully investigated. Purpose We tested hypothesis that rats...
Abstract Background Cardiac ischemia/reperfusion (I/R) injury caused the detrimental effects not only to heart but also brain. We previously reported that cardiac I/R led blood brain barrier (BBB) breakdown, mitochondrial dysfunction, and microglial hyperactivation, resulting in amyloid beta (Aβ) aggregation. Pretreatment with melatonin showed a neuroprotective effect against cerebral injury. However, of on pathologies following have never been investigated. Therefore, we hypothesize...
Abstract Background Myeloid differentiation factor 2 inhibitor (MD2i) is a novel anti-inflammatory agent that exerts favorable outcomes in various diseases including cardiac ischemia/reperfusion (I/R) injury. However, whether potent antioxidant N-acetyl cysteine (NAC) can augment the beneficial effects of MD2i rats with I/R injury have never been investigated. Purpose We tested hypothesis NAC increases against rats. Methods Rats were divided into either sham (n=6) or group (n=72). received...