Ferulic acid (FA) is a plant phenolic that has several pharmacological effects including antihyperglycaemic activity. Thus, the objective of this study to investigate effect FA on glucose and lipid metabolism in high-fat diet (HFD)-induced obese mice. Institute for Cancer Research (ICR) mice were fed HFD (45 kcal% fat) 16 weeks. At ninth week induction, orally administered with daily doses 25 50 mg/kg next eight The results show significantly reduced elevated blood serum leptin levels,...

The mechanism of the relaxant action and structure-activity relation flavonols (fisetin, quercetin, 3,3′, 4′-trihydroxyflavone) flavones (apigenin, chrysin, luteolin) were examined in rat isolated thoracic aorta. control responses to compared with observed after removal endothelium or presence L-type Ca2+ channel blocker, nifedipine (10−7M). effects flavonoids on contraction caused by influx extracellular agonist-induced release intracellular also investigated. exhibited...

Metabolic syndrome is a cluster of metabolic abnormalities characterized by obesity, insulin resistance, hypertension and dyslipidemia. Ferulic acid (FA) the major phenolic compound found in rice oil various fruits vegetables. In this study, we examined beneficial effects FA minimizing vascular dysfunction remodeling rat model high-carbohydrate, high-fat diet-induced changes, which regarded as an analogue (MS) man. Male Sprague-Dawley rats were fed high carbohydrate, fat (HCHF) diet 15%...

A high carbohydrate-high fat (HCHF) diet causes insulin resistance (IR) and metabolic syndrome (MS). Rice bran has been demonstrated to have anti-dyslipidemic anti-atherogenic properties in an obese mouse model. In the present study, we investigated beneficial effects of rice protein hydrolysates (RBP) HCHF-induced MS rats. After 12 weeks on this diet, HCHF-fed group was divided into four subgroups, which were orally administered RBP 100 or 500 mg/kg, pioglitazone 10 tap water for a further...

Curcumin from turmeric is commonly used worldwide as a spice and has been demonstrated to possess various biological activities. This study investigated the protective effect of curcumin on mouse model cadmium (Cd)—induced hypertension, vascular dysfunction oxidative stress. Male ICR mice were exposed Cd (100 mg/L) in drinking water for eight weeks. (50 or 100 mg/kg) was intragastrically administered every other day concurrently with Cd. induced hypertension impaired responses phenylephrine,...

Mulberry (Morus alba L.) leaf tea is promoted for its health benefits and the control of diabetes in Asian nations. The blood glucose lowering activity mulberry extract (MA) has been proven; however, molecular basis underlying this effect remains unclear. aim present work to elucidate mechanism antihyperglycemic action, by examining MA on uptake translocation transporter 4 protein (GLUT4) plasma membrane adipocytes isolated from diabetic rats. incubation with 5–45 μg/ml resulted 31–54%...

Oxidative stress has been shown to play an important role in the pathogenesis of diabetes-induced cardiac dysfunction. Protocatechuic acid (PCA) is a phenolic compound, main metabolite anthocyanin, which reported display various pharmacological properties. We proposed hypothesis that PCA exerts cardioprotection type 1 diabetic (T1DM) rats. T1DM was induced male Sprague–Dawley rats by single i.p. injection 50 mg/kg streptozotocin (STZ) and groups these animals received following treatments...

In recent years, a number of studies have investigated complementary medical approaches to the treatment hypertension using dietary supplements. Rice bran protein hydrolysates extracted from rice is rich source bioactive peptides. The present study aimed investigate vasorelaxation and antihypertensive effects peptides-derived (RBP) in rat model two kidney-one clip (2K-1C) renovascular hypertension. 2K-1C was induced male Sprague-Dawley rats by placing silver around left renal artery, whereas...

A mass of evidence has identified a promoting nitric oxide (NO) production in endothelial cells using natural products as potential strategy to prevent and treat hypertension. This study investigated whether the aqueous extract Moringa oleifera leaves (MOE) could lower mean arterial pressure (MAP) relax mesenteric beds rats via stimulating endothelium-derived NO production. Intravenous administration MOE (1-30 mg/kg) caused dose-dependent reduction MAP anesthetized rats. In pretreated with...

Quercetin, a dietary antioxidant flavonoid, possesses strong anti-inflammatory and cytoprotective activities. The effects were investigated in an animal model of lipopolysaccharide (LPS)-induced endotoxaemia vascular dysfunction vivo. Male ICR mice injected with LPS (10 mg/kg; i.p.). Quercetin (50 or 100 mg/kg) was intragastrically administered either before after administration. Fifteen hours injection, found endotoxaemic condition, as manifested by hypotension, tachycardia, blunted...

Umbelliferone (UMB) is a natural product that has several pharmacological effects including antihyperglycemic activity in diabetic rats. Thus, the objective of this study was to investigate effect UMB on insulin resistance and regulation glucose lipid metabolism type 2 Type diabetes induced rats by feeding high-fat diet (45 kcal% fat) single dose streptozotocin injection. After 8 weeks treatment, significantly reduced elevated blood levels increased liver glycogen serum adiponectin....

Rice bran, which is a byproduct of rice milling process, contains various nutrients and biologically active compounds. bran protein hydrolysates have pharmacological activities such as antidiabetic antidyslipidemic effects. However, there are limited studies about the mechanisms (RBP) on insulin resistance lipid metabolism. RBP used in this study were prepared from Thai Jasmine rice. When HepG2 cells treated with IL-6, IRS-1 expression Akt phosphorylation suppressed. This effect IL-6 was...

Background: One of the biological activities agar wood (Aquilaria sinensis Lour., Thymelaeaceae), is anti-hyperglycemic activity. The methanolic extract (ME) was proven to possess fasting blood glucose activity in rat and uptake transportation by adipocytes. Objective: To determine decreasing level constituents affordable for vivo test. If test positive, mechanism which positive ME, transportation, will be performed. Materials Methods: ME separated column chromatography identified...