This study examined the effect of Carthamus tinctorius (CT) extract plus captopril treatment on blood pressure, vascular function, nitric oxide (NO) bioavailability, oxidative stress and renin-angiotensin system (RAS) in N(ω)-Nitro-l-arginine methyl ester (l-NAME)-induced hypertension. Rats were treated with l-NAME (40 mg/kg/day) for five weeks given CT (75 or 150 300 500 mg/kg/day): (5 (300 two consecutive weeks. reduced pressure dose-dependently, most effective dose was mg/kg/day....

In the rat model of high carbohydrate, fat (HCHF) diet-induced metabolic syndrome (MS), previous studies have found that asiatic acid has an antihypertensive effect. this study, we investigated effects on vascular structure, function and renin-angiotensin system (RAS) in HCHF MS rats. Male Sprague–Dawley rats were divided into three treatment groups for 15 week study: a control group fed normal diet, diet plus % fructose their drinking water weeks, treated received weeks also orally...

A mass of evidence has identified a promoting nitric oxide (NO) production in endothelial cells using natural products as potential strategy to prevent and treat hypertension. This study investigated whether the aqueous extract Moringa oleifera leaves (MOE) could lower mean arterial pressure (MAP) relax mesenteric beds rats via stimulating endothelium-derived NO production. Intravenous administration MOE (1-30 mg/kg) caused dose-dependent reduction MAP anesthetized rats. In pretreated with...

The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries. Changes perfusion pressure to periarterial nerve stimulation and ACh were measured before after the Krebs solution containing antagonists. Distributions AChR arteries with an intact endothelium studied using Western blotting. expression level M1 M3 was significantly greater than that M2....

An aqueous extract of Moringa oleifera leaves (MOE) is known to cause relaxation mesenteric resistance arteries rats in which hypertension has been induced by the administration L-NAME, but mechanism(s) action MOE remains unclear. The purpose this study was investigate these mechanisms arterial beds isolated from L-NAME hypertensive rats. Methods: investigation vascular reactivity conducted on measuring changes perfusion pressure using an vitro system.MOE (0.001-3 mg 0.1 ml injection volume)...

Vascular blood vessels have various types of cholinergic acetylcholine receptors (AChR), but the source ACh has not been confirmed. Perivascular adrenergic nerves and nonadrenergic calcitonin gene-related peptide (CGRP)-containing (CGRPergic) innervate rat mesenteric arteries regulate vascular tone. However, function innervation remains unknown. The present study investigated by examining effects cholinesterase inhibitor (neostigmine), a muscarinic AChR antagonist (atropine), nicotinic...

Serum Levels of Heat Shock Protein 27 as a Potential Marker Diabetic Nephropathy in Egyptians with Type 2 DiabetesShahenda Mahgoub, Mahmoud Youns, Atef Bassyouni, Zeinab Hassan

5-HT is taken up by and stored in adrenergic nerves periarterial nerve stimulation (PNS) releases to cause vasoconstriction rat mesenteric arteries. The present study investigated whether PNS-released affects the function of perivascular calcitonin gene-related peptide-containing (CGRPergic) nerves.Rat vascular beds without endothelium with active tone were perfused Krebs solution. Changes perfusion pressure response PNS CGRP injection measured before (control) after solution containing (10...

Previous studies have demonstrated that nicotine releases protons from adrenergic nerves via stimulation of nicotinic ACh receptors and activates transient receptor potential vanilloid-1 (TRPV1) located on calcitonin gene-related peptide (CGRP)-containing (CGRPergic) vasodilator nerves, resulting in vasodilatation. The present study investigated whether perivascular release protons, which modulate axon-axonal neurotransmission.Perfusion pressure pH levels perfusate rat-perfused mesenteric...

Objective: To investigate the effect of Moringa oleifera leaf extract on angiogenesis and inflammatory process in a rat model streptozotocin-induced diabetic nephropathy. Methods: Four weeks after single injection 50 mg/kg streptozotocin, rats were treated with 100 or 200 mg/kg/day extract, 1 dapagliflozin, combination dapagliflozin for further eight weeks. Renal function, kidney histology, gene expression evaluated at end experiment. Results: function was significantly impaired as evidenced...

Mali-Nil Surin rice bran hydrolysate (MRH) contains highly nutritional proteins and beneficial phenolic compounds. This study investigated an antihypertensive effect of MRH evaluated the mechanisms mediating this action in Nω-nitro-L-arginine-methyl ester (L-NAME)-induced hypertensive rats. Antihypertensive activity was determined male rats orally administered with (100 or 300 mg/kg) enalapril (15 daily together L-NAME (50 mg/kg/day) drinking water, for 21 days. Concurrent oral treatment...

Moxifloxacin, a 4th generation of fluoroquinolones, is broad spectrum antibacterial agent against respiratory tract pathogens, including Gram-positive and Gram-negative bacteria, anaerobic bacteria atypical pathogens. In order to evaluate the efficacy safety generic moxifloxacin products, bioequivalence these products with an approved reference formulation should be demonstrated. Thus, aim this study was compare rate extent absorption new film coated tablet product (Rapiflox®, Atlantic...

Aqueous extract of Moringa oleifera leaves (MOE) is a potent inducer endothelium-dependent relaxation mesenteric resistance arteries rats induced to be hypertensive using Nω-nitro-L-arginine methyl ester (L-NAME). Hydrogen sulfide (H2S) has been shown participate in small arteries. Therefore, this study aimed investigate whether endothelial H2S-dependent signaling plays role the vasorelaxation response MOE.Mesenteric arterial beds isolated from L-NAME were set up an ex vivo perfusion system...

To compare the bioavailability of two meloxicam tablet formulations (MEL-OD, Zydus Cadila Healthcare Limited, India, as a test formulation and Mobic, Boehringer Ingelheim International GmbH, Germany, reference formulation) in healthy Thai male volunteers under fasting condition.A randomized, 2-treatment, 2-period, 2-sequence, single dose, crossover with washout period 2 weeks, was conducted 26 volunteers. Blood samples were collected 0, 1, 2, 3, 3.5, 4, 4.5, 5, 5.5, 6, 7, 8, 10, 12, 24, 36,...