A5063555500- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuropeptides and Animal Physiology
- Cancer Treatment and Pharmacology
- Nerve injury and regeneration
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Nitric Oxide and Endothelin Effects
- Cancer Immunotherapy and Biomarkers
- Chemotherapy-induced organ toxicity mitigation
- Computational Drug Discovery Methods
- Pharmacological Effects and Toxicity Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacovigilance and Adverse Drug Reactions
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Multiple Myeloma Research and Treatments
- Biosimilars and Bioanalytical Methods
- Aortic aneurysm repair treatments
- Melanoma and MAPK Pathways
- Drug Transport and Resistance Mechanisms
- Pharmacy and Medical Practices
- Aortic Disease and Treatment Approaches
- Angiogenesis and VEGF in Cancer
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
Tokushima University
2018-2025
Tokushima University Hospital
2018-2025
Ibero American University
2019-2021
Setsunan University
2012-2017
Okayama University
2005-2016
Niigata University
2012
Okayama University of Science
2011
The University of Tokyo
2009
Okayama University Hospital
2007
Macrolides are associated with cardiovascular toxicity risk. However, data on their profiles beyond QT prolongation limited, and differences in the among various macrolide antibiotics remain unclear. We investigated of different macrolides using VigiBase, a global database individual case-safety reports. Disproportionality analysis was performed WHO Pharmacovigilance database, from 1968 to December 2023. Associations between five (erythromycin, clarithromycin, azithromycin, josamycin,...
ABSTRACT Interstitial lung disease (ILD) is a clinically relevant adverse event associated with biologic agent use. However, the current incidence of ILD remains unclear as large‐scale risk assessments agents have not been conducted. The aim this study was to clarify association between use and development in clinical practice by detecting signals using spontaneous drug reaction database. VigiBase database used for reporting. analysis focused on nine biologics treat psoriasis, rheumatoid...
Abstract Immune checkpoint inhibitors (ICIs) elicit antitumour effects by activating the host immunity and cause immune-related adverse events (irAEs). ICI-related interstitial lung disease (ICI-ILD) is a fatal irAE that difficult to treat; moreover, its incidence relatively higher in patients with cancer. Therefore, early ICI-ILD detection intervention are important for patient safety. However, risk assessment method has not been established prediction of occurrence difficult. The aim our...
Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed investigate the effects RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; animal model). Male Wistar (6 weeks old) received 15% fructose solution drinking water for 8 weeks. FDR showed significant increases plasma levels triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index resistance), systolic blood pressure, but not glucose...
Abstract Background Combination therapy can offer greater efficacy on medical treatments. However, the discovery of synergistic drug combinations is challenging. We propose a novel computational method, SyndrumNET, to predict by network propagation with trans-omics analyses. Methods The prediction based topological relationship, network-based proximity, and transcriptional correlation between diseases drugs. SyndrumNET was applied analyzing six including asthma, diabetes, hypertension,...
Rehospitalization of patients with heart failure (HF) incurs high health care costs and increased mortality. Infection-related rehospitalizations in HF occur frequently, the risk increases age. This study aimed to identify factors associated infection-related older HF. Demographic, clinical, pharmacological data from 1061 acute who were enrolled Kochi Registry Subjects With Acute Decompensated Heart Failure (Kochi YOSACOI study) analyzed. Additionally, a machine learning approach was applied...
Clazosentan, a selective endothelin receptor antagonist, is used to prevent cerebral vasospasm. We investigated patient characteristics and concomitant medications associated with an increased risk of clazosentan-induced fluid retention, the factors which remain unknown. retrospectively reviewed cases adverse drug reactions from Japanese Adverse Drug Event Report (JADER) database, published by Pharmaceuticals Medical Devices Agency. time course retention onset following clazosentan...
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries. Changes perfusion pressure to periarterial nerve stimulation and ACh were measured before after the Krebs solution containing antagonists. Distributions AChR arteries with an intact endothelium studied using Western blotting. expression level M1 M3 was significantly greater than that M2....
Background Exosome-like nanoparticles (ELNs) mediate interspecies intercellular communications and modulate gene expression. Hypothesis/Purpose In this study, we isolated purified ELNs from the dried rhizome of Atractylodes lancea (Thunb.) DC. [Asteraceae] (ALR-ELNs), a traditional natural medicine, investigated their potential as neuroinflammatory therapeutic agents. Methods ALR-ELN samples were using differential centrifugation, physical features microRNA contents analyzed through...
Abstract In the treatment of chronic myeloid leukemia (CML), resistance to BCR‐ABL inhibitors makes it difficult continue and is directly related life expectancy. Therefore, asciminib was introduced market as a useful drug for overcoming resistance. While combining molecular targeted drugs avoid resistance, new inhibitor conventional should be used monotherapy in principle. we investigated synergistic effect mechanism combination imatinib. We generated imatinib‐resistant cells using human...
Drug repositioning is a cost-effective method to identify novel disease indications for approved drugs; it requires shorter developmental period than conventional drug discovery methods. We aimed prophylactic drugs oxaliplatin-induced peripheral neuropathy by using data from large-scale medical information and life science databases.Herein, we analyzed the reported between 2007 2017 retrieved FDA's database of spontaneous adverse event reports (FAERS) LINCS provided National Institute...
Abstract Polyethylene glycol (PEG) is a polymer covalently attached to proteins improve their half‐life and efficacy. We previously reported that the PEGylated granulocyte colony‐stimulating factor (PEG‐G‐CSF) immunogenic, which could adversely impact drug efficacy safety in animal models. Here, we analyzed relationship between anti‐PEG antibody titers clinical of PEG‐G‐CSF 19 hematological patients. A gradual decrease from baseline was observed after administration. Of participants, 10 were...
Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants prevention methods. Sodium valproic acid a prophylactic drug candidate with high potential for clinical application cisplatin-induced injury. Therefore, in this study, we aimed elucidate the mechanism underlying effect on injury mouse model and HK2 PODO cells toxicity. In various renal function parameters tubular damage scores were worsened by cisplatin, but...
Propolis, a honeybee product, contains variety of biologically active substances. The present study was designed to investigate the effects propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases plasma levels insulin, Homeostasis Model Assessment ratio (HOMA-R, an index resistance), body weight, and systolic blood pressure but...
Several reports from basic researches and clinical studies have suggested that xanthine oxidase (XO) inhibitors suppressive effects on cardiovascular diseases. However, the roles of a XO inhibitor, febuxostat (FEB), in pathogenesis vascular remodeling hypertension independent serum uric acid level remain unclear.To induce mice, angiotensin II (Ang II) was infused for 2 weeks with subcutaneously implanted osmotic minipump. FEB administered every day during Ang infusion. Aortic fibrosis...
Abstract Breakpoint cluster region‐Abelson murine leukemia (BCR‐ABL) inhibitors markedly improve the prognosis of chronic myeloid leukemia. However, high treatment adherence is necessary for successful with BCR‐ABL inhibitors. Therefore, an adequate understanding adverse event profiles essential. Although many events are observed in trials, accurate identification based only on clinical trial results difficult because strict entry criteria or limited follow‐up durations. In particular,...