A5101495092- Immunotherapy and Immune Responses
- Muscle metabolism and nutrition
- Gastric Cancer Management and Outcomes
- RNA Interference and Gene Delivery
- Cardiovascular and exercise physiology
- Metastasis and carcinoma case studies
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Physical Activity and Health
- Genetics and Physical Performance
- Phonocardiography and Auscultation Techniques
- Body Composition Measurement Techniques
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Obesity, Physical Activity, Diet
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Sports Performance and Training
- Cancer Treatment and Pharmacology
- Nutrition and Health in Aging
- Exercise and Physiological Responses
Fuchu Hospital
2024-2025
Fukuoka University
2011-2024
Kagawa University Hospital
2013-2024
The University of Texas Southwestern Medical Center
2023
Osaka Metropolitan University
2022
Metropolitan University
2022
Asahi General Hospital
2022
Hokkaido University
2022
Toyama University Hospital
2017-2021
Kanazawa Institute of Technology
2018-2020
The insertion (I) allele of the human angiotensin-converting enzyme (ACE) gene is associated with lower serum and tissue ACE activity, greater endurance performance enhanced mechanical efficiency trained muscle. We tested hypothesis that ACE-I may be increased slow-twitch fiber, which more efficient than fast-twitch fiber in low-velocity contraction, by examining association between genotype skeletal muscle (SMF) types 41 untrained healthy young volunteer subjects (31 males, 10 females, age...
Glucagon-like peptide-2 (GLP-2) is an important regulator of nutritional absorptive capacity with anti-inflammatory actions. We hypothesized that GLP-2 reduces intestinal mucosal inflammation by activation vasoactive polypeptide (VIP) neurons the submucosal plexus. Ileitis or colitis was induced in rats injection trinitrobenzene sulfonic acid (TNBS), administration dextran sodium sulfate (DSS) drinking water. Subsets animals received (1-33)-GLP-2 (50 mug/kg sc bid) either immediately 2 days...
Circulating concentrations of adiponectin, an adipocyte-derived protein, are increased by thiazolidinediones and weight reduction, accompanied with improvement in insulin sensitivity. The effect exercise training, another therapy to increase sensitivity (SI), on adiponectinemia is currently unclear. present study was undertaken clarify whether training-induced SI related changes healthy men. Twelve non-obese men underwent ergometer training at lactate threshold (LT) intensity for 60 min/day...
Objective . To evaluate the effect of calorie restriction-induced weight loss with or without aerobic exercise on liver fat. Methods Thirty-three adults visceral adiposity were divided into restriction (CR;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mi> </mml:mi><mml:mo>=</mml:mo><mml:mi> </mml:mi><mml:mn>18</mml:mn></mml:math>) CR and (CR + Ex;<mml:math id="M2"><mml:mi>n</mml:mi><mml:mi> </mml:mi><mml:mn>15</mml:mn></mml:math>) groups. Target...
Body water content increases during carbohydrate loading because 2.7-4-g binds each 1 g of glycogen. Bioelectrical impedance spectroscopy (BIS) allows separate assessment extracellular and intracellular (ECW ICW, respectively) in the whole body segment. However, BIS has not been shown to detect changes induced by loading. Here, we aimed investigate whether had sufficient sensitivity determine segmental distribution after Eight subjects consumed a high-carbohydrate diet containing 12...
Abstract Breakfast skipping has become an increasing trend in the modern lifestyle and may play a role obesity type 2 diabetes. In our previous studies healthy young individuals, single incident of breakfast increased overall 24-h blood glucose elevated postprandial glycaemic response after lunch; however, it was difficult to determine whether this due omission or extra energy (i.e. lunch plus contents). The present study aimed assess measure their hormone levels when individuals had...
Oxidative cross-coupling of alpha-aryl-beta,beta-difluoroenol silyl ethers with heteroaromatics in the presence Cu(OTf)(2) wet acetonitrile proceeds smoothly, affording heteroaryldifluoromethyl aryl ketones 61-88% yields. Alcohols also react as nucleophiles under same conditions to provide alkoxydifluoromethyl 73-80% [reaction: see text]
There is no consensus regarding optimal exercise timing for reducing postprandial glucose (PPG). The purpose of the present study was to determine most effective timing. Eleven participants completed four different patterns 1) exercise; 2) preprandial (jogging); 3) and 4) brief periodic intervention (three sets 1-min jogging + 30 s rest, every min, 20 times total) in a random order separated by minimum 5 days. Preprandial consisted intermittent (1 min rest per set) repeated 3 day. Total...
OBJECTIVE—To detect whether mild exercise training improves glucose effectiveness (SG), which is the ability of hyperglycemia to promote disposal at basal insulin, in healthy men. RESEARCH DESIGN AND METHODS—Eight men (18–25 years age) underwent ergometer lactate threshold (LT) intensity for 60 min/day 5 days/week 6 weeks. An insulin-modified intravenous tolerance test was performed before as well 16 h and 1 week after last session. SG insulin sensitivity (SI) were estimated using a...
Purpose: The purpose of this study was to evaluate the efficacy 3-dimensional computed tomographic angiography (3D CTA) using 16-channel multidetector-row helical tomography (MDCT) in preoperative visualization laparoscopic gastrectomy for early gastric cancer. Materials and Methods: Twenty consecutive patients with cancer who underwent (CT) examination MDCT (0.625 mm × 16) before surgery were included study. At a rate 4 mL/s, 2 mL/kg 300 mg I/mL contrast material intravenously injected....
Lymph node (LN) metastasis is one of the most important prognostic factors for undifferentiated-type early gastric cancer (EGC). The aim this study was to examine expansion micrometastasis in regional LNs clarify importance lymphadenectomy EGC.Clinicopathological features 307 patients with EGC who underwent gastrectomy between 1997 and 2010 at Department Surgical Oncology, Osaka City University, were retrospectively reviewed. Micrometastasis detected by immunohistochemistry using...
Genetic polymorphisms and sex differences are suggested to affect muscle fiber composition; however, no study has investigated the effects of genetic on composition with respect differences. Therefore, present examined in Japanese population. The included 211 healthy individuals (102 men 109 women). Muscle biopsies were obtained from vastus lateralis determine proportion myosin heavy chain (MHC) isoforms (MHC-I, MHC-IIa, MHC-IIx). Moreover, we analyzed α-actinin-3 gene ( ACTN3; rs1815739 ),...
Little information is available about the association between peripheral T-lymphocyte expression of programmed cell death protein 1 (PD1) and efficacy immune checkpoint inhibitor therapy in patients with non-small lung cancer (NSCLC). We analyzed PD1 cytotoxic associated 4 (CTLA4) blood T-lymphocytes NSCLC receiving therapy.Patients who were scheduled to receive treatment inhibitors prospectively enrolled this study November 2017 2018. Peripheral samples obtained within week before or after...
Mutations in the p53 gene are most common genetic alterations found human tumours, and these mutations result high levels of protein tumour cells. Since expression wild-type nonmalignant tissue usually much lower contrast, is an attractive target for cancer immunotherapy. We tested encoded HLA-A24 binding peptides their capacity to elicit anti-tumour cytotoxic T lymphocytes (CTL) vitro. These were murine p53-derived peptides, which being presented CTL by H-2Kdand H-2Kbmolecules, because...
The purpose of the present investigation was to assess relationship between bouts very short daily physical activity (PA) lasting <10 min with obesity and abnormal fat distributions. A total 42 females (age 50±6 years, height 156±5 cm, body weight 54±8 kg, mass index 22±3 kg/m<sup>2</sup>) participated in investigation. Computed tomography used evaluate area visceral adipose tissue subcutaneous (VAT SAT). All participants wore a pedometer one-axial accelerometer (Lifecorder, Kenz, Japan)...
We investigated the effect of macronutrient composition pre-exercise meals on endurance performance. Subjects consumed a high-carbohydrate diet at each meal for 3 days, followed by high-fat (HFM; 1007 ± 21 kcal, 30% CHO, 55% F and 15% P) or (HCM; 71% 20% 9% 4 h before exercise. Furthermore, just prior to test, subjects in HFM group ingested either maltodextrin jelly (M) placebo (P), while HCM jelly. Endurance performance was measured as running time until exhaustion speed between lactate...
Although survival of patients with metastatic breast cancer (MBC) has been significantly prolonged over the past decade due to improvement anti-cancer therapeutics, only a few survive for more than 10 years. It not determined which can have long-term treatment. To determine prognostic factors responsible survival, we retrospectively compared clinicopathologic MBC who survived 50 months or after diagnosis did not. Of 70 received chemotherapy between November 2005 and September 2011, 23 28...