A5038527025- Pharmacy and Medical Practices
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Pharmaceutical Practices and Patient Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Safe Handling of Antineoplastic Drugs
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Antimicrobial Resistance in Staphylococcus
- Analytical Methods in Pharmaceuticals
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Nuclear Receptors and Signaling
- Endoplasmic Reticulum Stress and Disease
- Cancer Treatment and Pharmacology
- Alzheimer's disease research and treatments
- Pharmacovigilance and Adverse Drug Reactions
- Chemotherapy-induced organ toxicity mitigation
- CAR-T cell therapy research
- Radical Photochemical Reactions
- RNA regulation and disease
- Adenosine and Purinergic Signaling
- Forensic and Genetic Research
- Genetic Neurodegenerative Diseases
- Biosimilars and Bioanalytical Methods
Asahikawa Medical University
2013-2023
Asahikawa City Hospital
2018
Hokkaido University of Science
2018
Hokkaido Pharmaceutical University
2011-2016
Kyoto University Hospital
2013-2014
Asahikawa Medical College Hospital
2005-2010
Midorigaoka Hospital
2005-2007
The University of Tokyo
1990-2005
Jichi Medical University
1995-1996
Pharmaceutical Biotechnology (Czechia)
1995
Abstract: 1‐Benzyl‐1,2,3,4‐tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography‐selected ion‐monitoring method. The level of 1BnTIQ very high some patients compared with that controls other neurological diseases, mean value being three times higher (parkinsonians: 1.17 ± 0.35 ng/ml CSF, n = 18; vs. controls: 0.40 0.10 11; SEM, not significantly different). pole test, toxicological examination to evaluate...
In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tetrahydroisoquinoline (TIQ), which is well noted for inducing parkinsonism, whereas another 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), markedly reduced. This result agrees with finding human idiopathic parkinsonianism, confirmed by our previous research. addition, pretreatment 1-MeTIQ completely prevented MPTP-...
Abstract: Significant densities of mRNA for the dopamine D4 receptor in cerebral cortex, particularly frontal lobe, have been reported rats and monkeys, supporting hypothesis pathology schizophrenia. Using northern blot analysis competitive reverse transcription‐polymerase chain reaction (RT‐PCR) method, we determined relative levels human brain regions to clarify whether cortical level is also higher humans. Northern revealed an unexpected profile brain. The detected size, 1.5 kb, was quite...
With the aid of a new chiral derivatizing reagent and sensitive specific assay using capillary gas chromatography/negative ion chemical ionization mass spectrometry, proportions R S enantiomers 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ) in mammalian tissues foods were studied. R- S-1MeTIQ derivatized with reagent, perfluoro-2-propoxypropionylchloride, clearly separated. The ratio was R/S = 0.24, 0.55 0.60 wine, cocoa mouse brain. predominated all samples. This result suggested that...
The goal of ulcerative colitis (UC) treatment has recently been shown to be "mucosal healing," as no drug directly induces mucosal healing. Probiotics possess sufficient safety, but their efficacy in the UC remains controversial because influence intestinal conditions. It is believed that identification bioactive molecules produced by probiotics and application will help solve this issue. We therefore identified a probiotic-derived long-chain polyphosphate molecule enhancing barrier...
Automation in the drug distribution processes is helpful to pharmacists creating new clinical services. We have ameliorated inventory control system seamlessly connected with physician order-entry system. This application, named Artima, allows functions be faster and more efficient real time. The medicines used our hospital are automatically fixed arranged sold-packages, ordered from each wholesaler by a fax-modem every day. Artima can search lot number expiration date of purchase delivery...
Shou-Wu-Pian, a herbal remedy formulated from Polygonum multiflorum (PM), has been extensively used for the treatment of hair-loss, constipation and vertigo in Asia, Europe U.S.A. Although recent reports have indicated severe liver damage occurred after taking Shou-Wu-Pian humans, studies on hepatotoxicity this limited, organ-specific adverse effect induced by PM intake remains to be confirmed. In study, hot-water-extracted was investigated vitro vivo mice. After treating primary cultured...
To ensure the proper use of pharmaceutical products, it is important to check outpatient prescriptions brought by patients when they are hospitalized. In recent few years, with introduction Diagnosis Procedure Combination (DPC) into medical service fee system, patient's hospital days have been reduced. As this makes necessary schedule operations soon after admission, essential that pharmacists prescription drugs, over-the-counter drugs and supplements as possible hospitalization. For...