A5073339468- Olfactory and Sensory Function Studies
- Pharmacy and Medical Practices
- Biochemical Analysis and Sensing Techniques
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Treatments and Studies
- Heart Failure Treatment and Management
- Inflammatory Bowel Disease
- NF-κB Signaling Pathways
- Rare-earth and actinide compounds
- Web Data Mining and Analysis
- Hemoglobin structure and function
- Food Allergy and Anaphylaxis Research
- Sentiment Analysis and Opinion Mining
- Biochemical and Molecular Research
- Erythrocyte Function and Pathophysiology
- Allergic Rhinitis and Sensitization
- Liver physiology and pathology
- Pharmacovigilance and Adverse Drug Reactions
- Advanced Text Analysis Techniques
- Magnetic Properties of Alloys
- Pharmaceutical Practices and Patient Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Asthma and respiratory diseases
- Synthesis and biological activity
- Pharmacological Effects and Toxicity Studies
Asahikawa Medical University
2010-2023
Chiba University
2014
Asahikawa Medical College Hospital
2007-2008
Hokkaido University
2005-2007
Asahikawa University
2007
Physiol (Belgium)
2007
Hokkaido Pharmaceutical University
2005
Daiichi-Sankyo (Japan)
1994
Abstract Background Correlations of disease phenotypes with glycosylation changes have been analysed intensively in the tumor biology field. Glycoforms potentially associated carcinogenesis, progression and cancer metastasis identified. In therapy, drug resistance is a severe problem, reducing therapeutic effect drugs adding to patient suffering. Although multiple mechanisms likely underlie cells anticancer drugs, including overexpression transporters, relationship glycans not well...
Abstract Background Drug resistance is a major problem in cancer chemotherapy. Acquisition of chemo-resistance not only reduces the effectiveness drugs, but also promotes side effects and markedly patient's quality life. However, number mechanisms have been reported are thought to be reason for difficulties solving drug-resistance problems. Result To investigate drug resistance, set cell lines with different levels sensitivity possessing 5-fluorouracil (5-FU) was established from colorectal...
Type I interferon (IFN) was originally identified as an immunomodulatory cytokine because of its antiviral activity. Further characterization biological effects revealed a prominent role in the direct control cell growth and potent antiangiogenic actions. IFN-alpha IFN-beta had both been classified type IFN, but differences their antitumor activities were reported. We confirmed difference antiproliferative IFN-alpha2b toward HT29 SW480 cells. IFN treatment observed to prolong cycle...
The goal of ulcerative colitis (UC) treatment has recently been shown to be "mucosal healing," as no drug directly induces mucosal healing. Probiotics possess sufficient safety, but their efficacy in the UC remains controversial because influence intestinal conditions. It is believed that identification bioactive molecules produced by probiotics and application will help solve this issue. We therefore identified a probiotic-derived long-chain polyphosphate molecule enhancing barrier...
Abstract Background Over the past few years, several drugs, each with a different mechanism, have been developed for treatment of pulmonary hypertension (PH) and are now prescribed in clinical setting. While optimal doses these drugs adults determined, dose children, however, is unclear. The aim this study was therefore, to measure blood drug levels analyze pharmacokinetics two such children. Methods From April 2010 May 2015, we prospectively enrolled 23 children PH bosentan and/or...
Cremophor EL (CrEL) is a non-ionic surfactant widely used as vehicle for insoluble drugs, including immunosuppressive and anticancer agents. Although CrEL has often been reported to induce sensory neuropathies, its action on voltage-gated ion channels remains unknown. We show here that modulates sodium current (INa) potassium (IK) of human neuroblastoma cells (SH-SY5Y). First, suppressed the amplitude INa IK. The suppression–concentration curve was gradual but IK steeper, indicating...
Face-to-face communication during on-site monitoring is important for clinical trial quality assurance. However, with the coronavirus disease early 2020 pandemic, medical institutions placed restrictions on hospital visits to secure their systems.
A distribution‐analyzing latex immunoassay (DALIA), based on the agglutination of particles coupled with mite or wheat allergen, was developed to determine allergen‐specific IgG in human sera. The immune complex between chemically coupled‐allergen and specific agglutinated specifically efficiently by employing an IgM‐type monoclonal second antibody strong amplification activity. extent evaluated determining relative ratio volumes (RV) agglutinates residual nonagglutinating a particle...
The authors attempted to manufacture an investigational drug using a manufacturing facility within the university without outsourcing it contract organization (CMO). However, they experienced difficulty in purchasing exclusive as raw material for process. made inquiries Ministry of Health, Labor and Welfare (MHLW) about interpretation Notice Director-General regarding Article 138 Act on Securing Quality, Efficacy, Safety Products Including Pharmaceuticals Medical Devices. response was that...