A5029145956- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Acute Kidney Injury Research
- Acute Myocardial Infarction Research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac Arrest and Resuscitation
- Congenital Diaphragmatic Hernia Studies
- Pregnancy and preeclampsia studies
- Lysosomal Storage Disorders Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Anesthesia and Sedative Agents
- Diet and metabolism studies
- Phosphodiesterase function and regulation
- Venous Thromboembolism Diagnosis and Management
- Cellular Mechanics and Interactions
- Connective tissue disorders research
- Cardiac electrophysiology and arrhythmias
- Dialysis and Renal Disease Management
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Systemic Sclerosis and Related Diseases
- Glycogen Storage Diseases and Myoclonus
Kanagawa Children's Medical Center
2023
Asahikawa Medical University
2011-2021
Asahikawa University
2013-2014
Otsu Municipal Hospital
2008
Background: Cardiac troponin I (cTnI) is currently considered to be the most sensitive and specific biochemical marker of acute coronary syndrome myocardial infarction. However, few reports have described use cTnI assays for evaluating abnormal hemodynamic load in children with congenital heart disease (CHD). It was hypothesized that significant overload due a left-to-right shunt induces injury. Methods Results: A highly assay used measure serum levels 30 atrial septal defect (ASD), 32...
Protein-losing enteropathy (PLE) is a rare and life-threatening complication that occurs after the Fontan procedure. We herein report case of an 11-year-old Japanese boy who developed PLE six times undergoing High-dose spironolactone therapy has been effective for 2 years. His high level serum aldosterone decreased to nearly normal range may have diuretic anti-inflammatory potential.
Abstract Background Malignant hyperthermia is an extremely dangerous condition that can occur with exposure to volatile inhalant anesthetics and depolarizing muscle relaxants, requires immediate intervention. Neurological complications have rarely been reported, no reports of electroencephalographic abnormalities or encephalopathy. Here, we report a case severe abnormality in the acute phase malignant eventually led diffuse cerebral cortical damage. Case presentation A 15-month-old Japanese...
Abstract Background Over the past few years, several drugs, each with a different mechanism, have been developed for treatment of pulmonary hypertension (PH) and are now prescribed in clinical setting. While optimal doses these drugs adults determined, dose children, however, is unclear. The aim this study was therefore, to measure blood drug levels analyze pharmacokinetics two such children. Methods From April 2010 May 2015, we prospectively enrolled 23 children PH bosentan and/or...
There are few reports on renal dysfunction in the remote period after biventricular repair, and biomarkers for early detection of not well understood. We examined whether fluctuation function occurs repair patients with congenital heart disease (CHD).Fourteen CHD were included. The examination values obtained by cardiac catheterization test indices based blood urine sampling compared.The median estimated glomerular filtration rate (eGFR) creatinine was 113 mL/min/1.73 m², eGFR cystatin C 117...
Background: Velocity-encoded cine magnetic resonance imaging (VEC-MRI) has recently been reported as effective for assessing not only pulmonary blood flow (Qp) but also arterial pressure (PAP) in adults. However, there have few reports on the usefulness of VEC-MRI PAP children with congenital heart disease (CHD). Methods and Results: We evaluated 34 CHD. Qp systemic flows (Qs) were determined by cardiac catheterization VEC-MRI. The right-to-left ratio (R/L) was measured perfusion...
Juvenile-onset systemic sclerosis (jSSc) is a rare condition, having unique characteristic features compared to adult-onset SSc. Although cardiac involvement (CI) known as leading cause of mortality overall in SSc, the importance CI jSSc has not been emphasized. Here we present 13-year-old female with overlapped dermatomyositis (DM) complicated CI. She developed skin thickness and induration, Raynaud’s phenomenon, digital pitting scars fingertips, skeletal myositis. Oral prednisolone pulse...
Background: The incidence of late complications related to the liver such as fibrosis/cirrhosis is increasing in patients who have undergone Fontan procedure and may contribute morbidity mortality. Recently, magnetic resonance elastography (MRE), a novel evaluation technique fibrosis, has been attracting attention. However, few reports described use MRE for evaluating fibrosis children with congenital heart disease (CHD). Methods: Thirty-two were examined divided into 4 groups: 12 CHD...
Abstract Background Pediatric continuous kidney replacement therapy (CKRT) uses blood as the priming fluid in CKRT circuit to prevent hemodilution and hypotension is dialyzed using a dialysate before start of CKRT. This study aimed investigate safety protocol no predialysis after underweight infants, based on hemodynamic laboratory data changes. Methods single-center retrospective cohort included children weighing < 5 kg cardiac surgery treated with from March 2019 February 2022. Our...
カテコラミン誘発多形性心室頻拍（Catecholaminergic polymorphic ventricular tachycardia: CPVT）は小児の突然死の原因の一つである．CPVTの初期治療としてはβ遮断薬が推奨されているが，それのみでは致死的なイベントを完全に防ぐことはできない．フレカイニドはIc群の抗不整脈薬であり，近年β遮断薬と同様にCPVT患者での運動誘発性の心室性不整脈の発症を減少させ，心イベントを予防すると報告された．フレカイニドに対する不整脈の改善は用量依存性であるとされているが，CPVT患者においてフレカイニド血中濃度と運動負荷心電図との直接的な関係をみた報告はない．我々は，8歳のCPVT患者に対して，β遮断薬とフレカイニドで治療を行い，治療効果判定として運動負荷心電図とフレカイニド血中濃度の測定を繰り返し行った．患者は十分な効果を得るために高用量のフレカイニド内服を要した．CPVT患者の治療に当たる際に，血中濃度と運動負荷心電図を繰り返し行うことはフレカイニドの効果判定に重要である．
Asplenia syndrome is frequently complicated by a total anomalous pulmonary venous connection. Pulmonary obstruction, following connection surgery, one of the risk factors for morbidity and mortality. In some patients, vasculature abnormal even in absence clinical evidence obstruction. We hypothesized that change hemodynamics could indicate abnormality vein patient with asplenia, single right ventricle, connection, Fontan procedure. Here, we present case obstruction which potential left was...
Mucopolysaccharidosis type 2 is a congenital lysosomal disease characterized by iduronate-2-sulfatase deficiency, which leads to excessive accumulation of glycosaminoglycans in tissue. Dysostosis, primarily involves decreased bone mineralization with morphological changes the bone, major skeletal condition mucopolysaccharidosis, but its pathophysiology not well known. Here, we report case mucopolysaccharidosis diagnosed at age years longitudinal follow-up data for more than 15 years....