A5060917252- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- Vasculitis and related conditions
- Neonatal Health and Biochemistry
- Inflammatory Myopathies and Dermatomyositis
- Parvovirus B19 Infection Studies
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Lysosomal Storage Disorders Research
- Legionella and Acanthamoeba research
- Infections and bacterial resistance
- Pancreatitis Pathology and Treatment
- Glycogen Storage Diseases and Myoclonus
- Pediatric Hepatobiliary Diseases and Treatments
- Kawasaki Disease and Coronary Complications
- Bladder and Urothelial Cancer Treatments
- Genetic Syndromes and Imprinting
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Cystic Fibrosis Research Advances
- Neurological disorders and treatments
Asahikawa Medical University
2010-2024
Asahikawa Kosei Hospital
2019
MRC Protein Phosphorylation and Ubiquitylation Unit
2018
University of Dundee
2018
Medical Research Council
2018
Asahikawa Medical College Hospital
2009-2010
The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is great concern. We clarified the risk factors underlying CRE infection mortality in Japan.We conducted a retrospective, multicentre, observational cohort study patients with infections at 28 university hospitals from September 2014 to December 2016, using Japanese National Surveillance criteria. Clinical information, including patient background, type infection, antibiotic treatment, and treatment outcome,...
To clarify the impact of congenital cytomegalovirus (CMV) infection on developmental disabilities, 20 children with disabilities unknown cause were analyzed.Five CMV positive and had no clinical manifestations at birth.Intracranial calcification was observed in 4 cases.Thus, is a significant disabilities.Cytomegalovirus one most common causes intrauterine infection.The prevalence ranges from 0.3% to 2.4% live births developed countries.Approximately 10% infected neonates are symptomatic...
To evaluate the parameters associated with significant gastrointestinal (GI) involvement in Henoch-Schönlein Purpura (HSP), and construct a scoring system for identification of patients at high risk gross blood stools. Data HSP hospitalized each seven institutes were retrospectively analyzed. Patients divided into four groups according to consequent severity GI involvement. Identification laboratory time admission then used differentiate groups, predict intestinal bleeding was constructed....
Abstract Background Shiga toxin‐producing Escherichia coli ‐associated hemolytic uremic syndrome (STEC‐HUS) is a life‐threatening condition complicated by acute kidney injury, respiratory distress syndrome, and central nervous system disorders. The early identification of high‐risk patients required to facilitate timely appropriate treatment. Methods medical records with STEC‐HUS treated at 11 hospitals in Hokkaido, Japan, were reviewed retrospectively. A multi‐institutional retrospective...
Abstract The A20-binding inhibitor of NF-κB 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component the tumor progression locus (Tpl2) kinase complex. We generated a knock-in mouse expressing ubiquitin-binding–defective mutant ABIN2[D310N]. expression Tpl2 its activation by TLR agonists in macrophages or IL-1β fibroblasts from these mice was unimpaired, indicating that interaction ABIN2 oligomers not required for stability Tpl2. ABIN2[D310N] displayed intestinal...
Abstract Background The appropriate antimicrobial treatment period for febrile urinary tract infection ( UTI ) can be changed, depending on whether the patient has acute focal bacterial nephritis AFBN ). aim of this study was to clarify characteristics compared with those pyelonephritis APN and establish a strategy detect . Methods A total 77 patients diagnosed were enrolled. They divided into n = 64) groups 13). clinical data other laboratory biomarkers retrospectively analyzed. Results...
Context Effects of liposomal particles on immune function have not been adequately investigated. Earlier reports indicate that intravenous injection rats with pegylated liposomes comprising chemically defined specific lipids produces myeloid derived suppressor-cell (MDSC)-like cells in the spleen.Objectives After liposome injection, we sought a cell surface marker expressed specifically splenic macrophages. Then assessed immunosuppressive activity macrophages positive for marker....
Anti-nuclear matrix protein-2 (NXP2) antibody is associated with the severe, chronic myositis phenotype in juvenile dermatomyositis (JDM). Although hyperproduction of type I interferon considered to play an important role JDM, sequential changes biomarkers this pathophysiology have not yet been described detail. An 8-year-old boy who presented muscle weakness, heliotrope rash, and Gottron's papules was diagnosed JDM. With regard myositis-specific autoantibodies, anti-NXP2 detected. increase...
Juvenile-onset systemic sclerosis (jSSc) is a rare condition, having unique characteristic features compared to adult-onset SSc. Although cardiac involvement (CI) known as leading cause of mortality overall in SSc, the importance CI jSSc has not been emphasized. Here we present 13-year-old female with overlapped dermatomyositis (DM) complicated CI. She developed skin thickness and induration, Raynaud’s phenomenon, digital pitting scars fingertips, skeletal myositis. Oral prednisolone pulse...
A heterozygous mutation of STAT3 causes autosomal dominant hyper immunoglobulin E (IgE) syndrome; however, there are still many unclear points regarding the clinical spectrum this syndrome.In addition to a description patients in terms pedigree, genetic analysis, quantitation peripheral blood Th17 and ex vivo IL-17 production were carried out.The proband, 2-year-old boy (Patient 1) with early onset atopic dermatitis-like eczema recurrent bacterial infections, was suspected syndrome on basis...
Lower respiratory tract infections due to syncytial virus are associated with morbidity and mortality in infants children. Thus precise elucidation of lower infection pathophysiology is important.Medical records hospitalized patients were reviewed. Patients divided into three groups. Group I: who improved without oxygen supply. II: received supply, but not nasal high-flow cannula therapy. III: cannula. also by age group the <6 months ≥6 Parameters for differentiating severity among groups...
Abstract Infectious mononucleosis (IM) caused by Epstein-Barr virus (EBV) is a relatively common disease in adolescents and children. There have been few reports on serial changes EBV DNA load IM infants, we herein describe the precise clinical course as well kinetics of case infantile IM. An 11-month-old girl presented with persistent fever, splenomegaly, rash was diagnosed basis her despite absence significant increase anti–viral capsid antigen-IgM. The result cytomegalovirus antigenemia...