A5056320978- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- Vibrio bacteria research studies
- Antifungal resistance and susceptibility
- Bacterial biofilms and quorum sensing
- Infection Control in Healthcare
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Listeria monocytogenes in Food Safety
- Infections and bacterial resistance
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Orthopedic Infections and Treatments
- Essential Oils and Antimicrobial Activity
- Enterobacteriaceae and Cronobacter Research
- Bacteriophages and microbial interactions
- Infectious Disease Case Reports and Treatments
Gifu University Hospital
2018-2024
Tokyo National Hospital
2018
Yokohama Municipal Minato Red Cross Hospital
2018
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2016
Essen University Hospital
2016
Kanazawa Medical University
2011-2015
Nagoya University
2001-2011
The University of Queensland
2009-2011
Nagoya University Hospital
2003-2009
Nagoya Medical Center
2007
To describe the population pharmacokinetics of vancomycin in patients with gram-positive infections and to investigate influence type infectious disease.A two-compartment open model was adopted as a pharmacokinetic model. The nonlinear mixed-effects used analyze models.We propose one general disease type-specific showed that clearance (CL) linearly correlated estimated creatinine (CL(CR)) when CL(CR) less than 85 mL/min, expressed by CL(L/h) = 0.0322 x + 0.32. distribution volumes central...
The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is great concern. We clarified the risk factors underlying CRE infection mortality in Japan.We conducted a retrospective, multicentre, observational cohort study patients with infections at 28 university hospitals from September 2014 to December 2016, using Japanese National Surveillance criteria. Clinical information, including patient background, type infection, antibiotic treatment, and treatment outcome,...
ABSTRACT Listeriolysin O (LLO), a cholesterol-binding cytolysin of Listeria monocytogenes , exhibits cytokine-inducing and cytolytic activities. Because the activity was abolished by cholesterol treatment but not, these activities appeared to be linked different domains LLO molecule. In this study, we constructed recombinant full-length (rLLO529) various truncated derivatives examined their cytolytic, cholesterol-binding, gamma interferon (IFN-γ)-inducing rLLO529 exhibited both...
We describe the first case of bloodstream infection caused by Rhodococcus erythropolis. The identification was performed using 16S rRNA sequencing. This illustrates that non-equi infections may be underdiagnosed due to difficulties in routine clinical microbiology laboratory.
We herein report the first case of necrotizing fasciitis caused by Pigmentibacter ruber. The isolated strain could not be identified biochemical characterization and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). was as P. ruber 16S ribosomal RNA whole genome sequencing. Although much remains unknown about pathogenicity this bacterial specie in humans, it has been revealed to cause life-threatening infections, such septicemia fasciitis. Since...
Objective: Invasive fungal infection is a major cause of morbidity and mortality in patients with febrile neutropenia unresponsive to antibacterial treatment. Empirical antifungal therapy amphotericin B has been the standard care for these patients; however, there remains need less toxic alternative drugs. Patients Methods: We conducted prospective study evaluate efficacy safety micafungin (MCFG), novel agent echinocandin class, an empirical setting neutropenia. Results: A total 31 acute...
Susceptibility to a range of antimicrobial agents was determined among isolates Streptococcus pneumoniae, pyogenes, and Haemophilus influenzae collected in 12 centers throughout Japan during years 1–5 (the respiratory seasons 1999–2004) the longitudinal Prospective Resistant Organism Tracking Epidemiology for Ketolide Telithromycin study. The most frequent source S. pneumoniae from patients with community-acquired pneumonia (CAP) (25.3%). Reduced susceptibility penicillin or erythromycin...
Molecular epidemiological techniques, such as pulsed-field gel electrophoresis (PFGE), or multilocus sequence typing (MLST) have facilitated our understanding of the transmission routes nosocomial infections by Pseudomonas aeruginosa. However, they are time consuming and technically demanding. To perform molecular analysis in a standard microbiology laboratory, we aimed to develop simpler effective technique based on open-reading frame (ORF) distribution patterns detected PCR, which call...
Background Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has the potential to permit early organism identification and optimization antibiotic therapy. However, MALDI-TOF MS combined with antimicrobial stewardship is available at only a limited number institutions. Here, we evaluated clinical impact implementing intervention in patients bloodstream infections. Methods We conducted single-centre, prospective cohort study evaluate Processes...
Listeriolysin O (LLO), a member of the cholesterol-dependent cytolysin (CDC) family, is major virulence factor Listeria monocytogenes and contributes to bacterial escape from intracellular killing macrophages. LLO activated under weakly acidic conditions; however, molecular mechanism this pH-dependent expression cytolytic activity poorly understood. In study, CDCs including LLO, ivanolysin (ILO), seeligeriolysin (LSO), pneumolysin (PLY), streptolysin (SLO) perfringolysin (PFO) were prepared...
To study comprehensive toxin profiles and the chromosomal diversity of current Japanese hospital-associated meticillin-resistant Staphylococcus aureus (HA-MRSA) strains, we conducted PCR-based identification 28 genes, staphylococcal cassette chromosome mec (SCC ) typing PFGE analysis 208 MRSA strains isolated from 100 hospitals throughout Japan. Of tested HA-MRSA 80.3 % were tst -positive. The most frequent gene profile was characterized by carriage 13 , sec seg sei sel sem sen seo lukED hla...
Implementation of an antifungal stewardship programme is a recognized need. However, there insufficient information to confirm the impact interventions. Further, few studies have evaluated clinical effects intervention using 1-3, β-D-glucan (βDG) testing. The aim present study was evaluate implementing with monitoring βDG values on use and outcomes.A single institutional prospective cohort conducted daily reviews agents patients who measured since August 2013. Antifungal consumption outcomes...
Exposure of healthcare workers to patients with rapidly fatal infections invariably raises concerns regarding the risk occupational acquisition. We describe acquisition Streptococcus pyogenes by 2 nurses from a patient pneumonia and review previously reported cases transmission bacterial pathogens workers.
Secondary bacterial pneumonia due to community onset methicillin-resistant Staphylococcus aureus (MRSA) has become a highly publicised cause of influenza-associated death. There is risk that case reports fatal outcomes with post-influenza MRSA may unduly influence antibiotic prescribing.The aim this study was demonstrate the incidence community-onset in 2009 H1N1 influenza patients.The microbiology records patients positive for A (H1N1) were reviewed blood or respiratory tract cultures and...
ABSTRACT Seeligeriolysin O (LSO), one of the cholesterol-dependent cytolysins produced by Listeria seeligeri , shows 80% homology to listeriolysin (LLO) monocytogenes at amino acid sequence level. In addition cytolytic activity, LLO has been shown exhibit cytokine-inducing activity. order determine whether LSO is also capable exhibiting these two different activities, we constructed a recombinant full-length (rLSO530) and noncytolytic truncated derivative with C-terminal deletion (rLSO483)...