A5014248056- Asthma and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Allergic Rhinitis and Sensitization
- Intracranial Aneurysms: Treatment and Complications
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- Antibiotic Resistance in Bacteria
- Respiratory and Cough-Related Research
- Antimicrobial Peptides and Activities
- Inflammatory mediators and NSAID effects
- Erythrocyte Function and Pathophysiology
- Peroxisome Proliferator-Activated Receptors
- Antibiotic Use and Resistance
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Antimicrobial Resistance in Staphylococcus
- Sepsis Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Infection Control in Healthcare
- Mycobacterium research and diagnosis
- IL-33, ST2, and ILC Pathways
- T-cell and Retrovirus Studies
- Cerebrovascular and Carotid Artery Diseases
- Chemokine receptors and signaling
Hirosaki University
2014-2023
Hirosaki University Hospital
2015-2023
Toujinkai Hospital
2016-2018
Jichi Medical University
2018
Jichi Medical University Saitama Medical Center
2018
Southern Methodist University
2017
Yokosuka Kyosai Hospital
2015
Nippon Medical School
2004-2010
Akita University
1998-2007
Kindai University
2000
Abstract Background Spread of vancomycin-resistant Enterococcus (VRE) is a global concern as significant cause healthcare-associated infections. A series VR E faecium (VREf) outbreaks caused by clonal propagation due to interhospital transmission occurred in six general hospitals Aomori prefecture, Japan. Methods The number patients with VREf was obtained from thirty seven participating the local network prefecture. Thirteen performed active screening tests for VRE. Whole genome sequencing...
The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is great concern. We clarified the risk factors underlying CRE infection mortality in Japan.We conducted a retrospective, multicentre, observational cohort study patients with infections at 28 university hospitals from September 2014 to December 2016, using Japanese National Surveillance criteria. Clinical information, including patient background, type infection, antibiotic treatment, and treatment outcome,...
Abstract 15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2), mainly produced by mast cells, is known as a potent lipid mediator derived from PGD2 in vivo. 15d-PGJ2 was thought to exert its effects on cells exclusively through peroxisome proliferator-activated receptor-γ (PPARγ) and chemoattractant receptor-homologous molecule expressed Th2 (CRTH2), which are both human eosinophils. However, the physiological role of remains unclear, because concentration generated vivo generally much lower than that required...
This study investigated a new method of flow cytometry (FCM) for analysis red blood cell (RBC) osmotic fragility. Venous peripheral collected in sampling tube coated with EDTA 2Na was analyzed using FCM to determine RBC RBCs were represented as double-peaked forward scatter (FSC) histogram FCM. showed ballooning and spherical shape change hypotonic solutions before hemolysis. The expressed disappearance the minor peak by narrowing shift right FSC histogram. process hemolysis shrinking...
Abstract The effects of inflammatory responses and polymorphisms the genes encoding cytochrome P450 (CYP) ( CYP2C19 CYP3A5 ), flavin‐containing monooxygenase 3 FMO3 pregnane X receptor NR1I2 constitutive androstane NR1I3 CYP oxidoreductase POR ) on ratio voriconazole (VRCZ) N ‐oxide to VRCZ (VNO/VRCZ) steady‐state trough concentrations (C 0h were investigated. A total 56 blood samples collected from 36 Japanese patients. Results multiple linear regression analyses demonstrated that presence...
Reactive oxygen species (ROS) from eosinophils are known to cause tissue damage in allergic inflammation. CC chemokines, especially eotaxin and regulated on activation, normal T‐cell expressed secreted (RANTES), involved not only chemotaxis but also eosinophil such as ROS production. It has been shown that patients functionally equivalent those subjects. In the present study, characteristics of chemokineprimed production controls were compared. After pretreatment with stimulated calcium...
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<i>Background:</i> Prostaglandin D<sub>2</sub> (PGD<sub>2</sub>), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. PGD<sub>2</sub> demonstrates its effects through two G-protein-coupled receptors, DP and CRTH2. The PGD<sub>2</sub>/CRTH2 system mediates chemotaxis of eosinophils, basophils, Th2 which are involved the induction inflammation. Although recent studies have shown that...
Summary Background and Objective Inhaled corticosteroids ( ICS ) inhaled combined with long‐acting beta2‐agonist / LABA are standard treatments for asthma. However, factors that might help reduce medication in well‐controlled asthma unknown. We classified problems of patients into biological, psychological adherence factors, investigated associated the indication failure a step‐down treatment. Methods Two hundred twenty two receiving or were assessed physical psychiatric followed up one year...
<i>Background:</i> C-C chemokines and adhesion molecules expressed on eosinophils play an important role in the pathology of allergic inflammatory disease. such as eotaxin or RANTES are involved β<sub>2</sub> integrin expression purified eosinophils; so far we have no data unpurified peripheral blood. We measured β<sub>1</sub> activation after stimulation with vitro using whole-blood flow-cytometric analysis. <i>Methods:</i> Heparinized whole...
Eosinophils are major effector cells in allergic diseases including asthma. Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear receptor that regulates immune reaction. We have previously demonstrated human eosinophils express PPARγ and stimulation with synthetic agonist for attenuated the factor-induced eosinophil survival chemotaxis. However, modulator of expression has not yet been studied. In this study, we investigated effect theophylline dexamethasone (widely used drugs...
The technical factors and surgical methods employed in carotid endarterectomy are controversial. In particular, whether or not to use an indwelling arterial shunt during remains a source of conflict. We describe rare case which uncomplicated was followed by distal internal artery dissection suggest that this devastating complication due intimal damage produced the shunt.
G protein-coupled estrogen receptor (GPER) is an located on the plasma membrane. We previously reported that administration of G-1, a GPER-specific agonist, suppressed development acute ovalbumin (OVA)-induced asthma in mouse model. Herein, we evaluate involvement GPER model chronic OVA asthma. G-1 or saline was administered subcutaneously to BALB/c mice with asthma, and pathological immunological evaluation performed. In addition, Foxp3-expressing CD4-positive T-cells spleen ILC2 lungs were...
Selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline (SNRIs) are often used to treat outpatients with psychogenic somatoform symptoms but prove ineffective in some cases. The metabolite 3-hydroxybutyrate (3HB) is currently attracting attention as a marker of the severity depression. We investigated whether serum 3HB levels patients can predict effectiveness sertraline venlafaxine.Physical psychiatric problems were assessed 132 outpatients, symptomatic response...
Eosinophils are considered to be the major inflammatory cells in asthma. Since regulated on activation, normal T expressed and secreted (RANTES) is a potent chemoattractant for various important such as eosinophils well memory potentially recruiting these an inflamed focus, RANTES has been play key role allergic disorders To extend our understanding of participation relation production response specific allergen asthma, we examined from peripheral blood mononuclear cultured with atopic...
Theoretical investigations predicting the epidemic curves of seasonal influenza have been demonstrated so far; however, there is little empirical research using ever accumulated curves. The effects vaccine coverage and information distribution on epidemics were evaluated.Four indices for (i.e., onset-peak duration, onset-end ratio duration to steepness curves) defined, correlations between these anti-flu drug prescription dose, coverage, volume media search trend through internet analyzed....