A5052880224- Diabetes Management and Research
- Circadian rhythm and melatonin
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Adrenal Hormones and Disorders
- Cleft Lip and Palate Research
- Pituitary Gland Disorders and Treatments
- Spaceflight effects on biology
- Congenital heart defects research
- Diabetes Treatment and Management
- Electrolyte and hormonal disorders
- Adolescent and Pediatric Healthcare
- Sleep and related disorders
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- bioluminescence and chemiluminescence research
- Growth Hormone and Insulin-like Growth Factors
- Pediatric health and respiratory diseases
- Vitamin D Research Studies
- Neuroscience of respiration and sleep
- Light effects on plants
- Thyroid Disorders and Treatments
Asahikawa Medical University
2013-2023
Foundation for Growth Science
2016
Asahikawa Medical College Hospital
2010-2013
Hokkaido University
1998-2009
University of Massachusetts Chan Medical School
2005-2008
Toray (United States)
2008
The pattern of circadian behavioral rhythms is photoperiod-dependent, highlighted by the conservation a phase relation between rhythm and photoperiod. A model two separate, but mutually coupled, oscillators has been proposed to explain photoperiodic responses in nocturnal rodents: an evening oscillator, which drives activity onset entrains dusk, morning end dawn. Continuous measurement clock gene Per1 expression bioluminescence reporter enabled us identify separate oscillating cell groups...
Effects of daily physical exercise in the morning or evening were examined on circadian rhythms plasma melatonin and core body temperature healthy young males who stayed an experimental facility for 7 days under dim light conditions (<10 lux). Sleep polysomnogram (PSG) heart rate variability (HRV) also measured. Subjects performed 2-h intermittent with a bicycle ergometer at ZT3 ZT10 four consecutive days, where zeitgeber time 0 (ZT0) was wake-up. The rising phase rhythm delayed by 1.1 h...
This clinical practice guideline of the diagnosis and treatment adrenal insufficiency (AI) including crisis was produced on behalf Japan Endocrine Society. evidence-based developed by a committee all authors, reviewed subcommittee The Japanese version has already been published, essential points have summarized in this English language version. We recommend diagnostic tests, measurement basal cortisol ACTH levels combination with rapid (250 μg corticotropin) test, CRH for particular...
Effects of timed physical exercise were examined on the reentrainment sleep-wake cycle and circadian rhythms to an 8-h phase-advanced sleep schedule. Seventeen male adults spent 12 days in a temporal isolation facility with dim light conditions (<10 lux). The schedule was by 8 h from their habitual times for 4 days, which followed free-run session 6 during subjects deprived time cues. During shift schedule, group (n = 9) performed bicycle ergometer early middle waking period 2 each. control...
Abstract Context Lipoid congenital adrenal hyperplasia (LCAH) is caused by mutations in STAR. Classic (CLCAH) and nonclassic (NCLCAH) forms were reported as total partial deficiencies, respectively, of gonadal steroid hormones. The rarity LCAH has precluded large-scale epidemiological clinical investigations. Objective To determine the characteristics 2 LCAH. Design A multicenter cross-sectional cohort study Japan on December 1, 2017. Participants Fifty-seven patients with (median age, 23.7...
Effects of two different light intensities during daytime were examined on human circadian rhythms in plasma melatonin, core body temperature, and wrist activity under a fixed sleep schedule. Sleep qualities as indicated by polysomnography subjective sleepiness also measured. In the first week, dim conditions ( approximately 10 lx), onset peak nocturnal melatonin rise significantly delayed, whereas end was not changed. The level affected. As result, width shortened. second bright 5,000...
Somatic activating GNAS mutations cause McCune-Albright syndrome (MAS). Owing to low mutation abundance, mutant-specific enrichment procedures, such as the peptide nucleic acid (PNA) method, are required detect in peripheral blood. Next generation sequencing (NGS) can analyze millions of PCR amplicons independently, thus it is expected low-abundance quantitatively. In present study, we aimed develop an NGS-based method somatic mutations. encompassing exons 8 and 9 GNAS, which most occur,...
The Research Committee of Disorders Adrenal Hormones, Japan, undertook a nationwide epidemiological study primary aldosteronism (PA). present was undertaken as part this to reveal the relationship between type treatment and prognosis PA. In survey, 4161 patients with PA during period January 1, 2003-December 31, 2007 were reported from 3252 departments internal medicine, pediatrics urology. secondary questionnaire that requested detailed clinical information on individual sent those...
Recently, GATA6 heterozygous loss‐of‐function mutations were reported to cause pancreatic agenesis and congenital heart defects (PACHD [OMIM:600001]). However, the molecular mechanisms resulting from premature termination codons have not been examined in this disorder. The objective of study was perform a genetic analysis patient with PACHD. A female presented ventricular septal defect, patent ductus arteriosus, diaphragmatic hernia at birth. Permanent neonatal diabetes mellitus exocrine...
Dual oxidase 2 (DUOX2) mutations are a cause of dyshormonogenesis (DH) and have been identified in patients with permanent congenital hypothyroidism (PH) transient (TH). We aimed to elucidate the prevalence phenotypical variations DUOX2 mutations.Forty-eight Japanese DH were enroled analysed for sequence variants DUOX2, DUOXA2, TPO using polymerase chain reaction-amplified direct sequencing.Fourteen including 10 novel variants, 11 patients. more prevalent (11/48, 22.9%) than (3/48, 6.3%)...
Background: Population impact of modifiable risk factors on orofacial clefts is still unknown. This study aimed to estimate population attributable fractions (PAFs) for nonsyndromic cleft lip with or without palate (CL±P) and only (CP) in Japan.
Background Glycated albumin (GA) reflects glycemic control in patients with neonatal diabetes mellitus (NDM). However, GA NDM is apparently low relation to glycemia. Objective To establish the reference intervals for healthy infants. Subjects and Methods Fifty-eight healthy, full-term newborn infants were used define values investigate its relationship plasma glucose (PG) serum albumin. The categorized into three groups according age: group A, 5 (4–6) median (range) d: n = 18; B, 33 (30–38)...
This prospective cohort study aimed to examine the associations between mold growth, type of stoves, and fragrance materials early childhood wheezing asthma, using data from Japan Environment Children's Study. Mold growth at home, usage kerosene/gas stove, wood stove/fireplace, air freshener/deodorizer were surveyed a questionnaire 1.5-year-old, doctor-diagnosed asthma during previous year obtained 3-year-old questionnaire. Multilevel logistic regression analysis was performed evaluate...
Background As the presence of fetal hemoglobin (HbF) affects accuracy A1c (HbA1c) analysis methods, HbA1c measurement may not be a good indicator for patients with neonatal diabetes mellitus, whereas glycated albumin (GA) indicator. Objective To investigate whether total (GHb) or HbF-adjusted (adj-HbA1c) can act as glycemic control marker in infants. Subjects and Methods Plasma glucose (PG), GA, HbF, GHb measured using affinity method, latex-immunoturbidimetry (LA) high-performance liquid...
There is concern that vitamin D deficiency prevalent among children in Japan as well worldwide. We conducted a nationwide epidemiologic survey of symptomatic to observe its incidence rate Japanese children. A questionnaire inquiring the number new patients with rickets and/or hypocalcemia for 3 years was sent 855 randomly selected hospitals pediatrics department Japan. In this survey, we found 250 were diagnosed deficiency. The estimated per year 183 (95% confidence interval (CI): 145–222)....
Background We previously reported that glycated albumin (GA) levels increased in an age-dependent manner infancy. In order to determine whether this phenomenon is true from infancy adulthood, we investigated the GA non-diabetic subjects of a wide range age. Methods 376 [average age, 31.8 ± 23.8 years (4 days–78 years)] were determined. A relationship between and logarithmically transformed age [log(age)] was analysed. Results significantly positively correlated with log(age) [ R = 0.865, P...