A5072718019- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Autoimmune Bullous Skin Diseases
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Hedgehog Signaling Pathway Studies
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Chemotherapy-related skin toxicity
- Vascular Tumors and Angiosarcomas
- Dermatological and Skeletal Disorders
- Soft tissue tumor case studies
- Cancer Treatment and Pharmacology
- Nail Diseases and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Eosinophilic Disorders and Syndromes
- Oral and Maxillofacial Pathology
- Chronic Lymphocytic Leukemia Research
- Urticaria and Related Conditions
- Cancer Immunotherapy and Biomarkers
- Neurofibromatosis and Schwannoma Cases
- Restraint-Related Deaths
- Vector-Borne Animal Diseases
- Dermatology and Skin Diseases
- T-cell and Retrovirus Studies
Ehime Prefectural Central Hospital
2021-2024
Tokushima University
2000-2022
Ibero American University
2019
Tokushima Red Cross Hospital
2015-2019
Komatsu (Japan)
2015
Fibroblast growth factors (FGFs) and their receptors (FGFRs) control a wide range of biological functions; however, involvement in the pathogenesis dermatofibroma (DF) dermatofibrosarcoma protuberans (DFSP) is currently unknown. In this study, we first confirmed histological diagnosis by detecting fusion COL1A1-PDGFB transcripts DFSP, examined expression all FGFRs (FGFR1-4), some ligands (FGF1, 2, 9), forkhead box N1 (FOXN1) as downstream target FGFR3 DF DFSP immunohistochemical analysis....
The authors have no conflicts of interest to report.
Band-shaped presentation of cutaneous angiosarcoma has not been reported. Cutaneous should be included in the differential diagnosis when a persistent erythematous lesion is observed head and neck region an elderly patient without clear explanation, but skin biopsy required for accurate diagnosis.
症例：79 歳，男性
Cowden syndrome (CS) is an autosomal dominant inherited disorder characterized by macrocephaly and multiple hamartomas. The responsible gene PTEN (phosphate tensin homolog detected on chromosome 10), which negatively regulates cell proliferation survival. We herein present a 46-year-old woman with the typical clinical features of CS. A DNA sequencing analysis coding regions flanking introns revealed novel heterozygous mutation (c.403A > G, p.Ile135Val) in exon 5 that had not been previously...