A5032168576- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- GDF15 and Related Biomarkers
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Muscle Physiology and Disorders
- Frailty in Older Adults
- Lipid metabolism and biosynthesis
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Nail Diseases and Treatments
- Psoriasis: Treatment and Pathogenesis
- Endometrial and Cervical Cancer Treatments
- Neonatal Respiratory Health Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Urticaria and Related Conditions
- Pain Management and Placebo Effect
- Coenzyme Q10 studies and effects
- Reproductive Biology and Fertility
- Congenital Diaphragmatic Hernia Studies
- Pancreatic and Hepatic Oncology Research
- Growth Hormone and Insulin-like Growth Factors
- Muscle metabolism and nutrition
German Institute of Human Nutrition
2015-2024
University of Potsdam
2020
Max Planck Institute for Metabolism Research
2018
University of Alabama
2012
Article6 February 2020Open Access Transparent process Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress Mario Ost Corresponding Author [email protected] orcid.org/0000-0002-1811-2049 Department of Physiology Energy Metabolism, German Institute Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany Search for more papers by this author Carla Igual Gil Nutritional Science, University Potsdam, Verena Coleman Susanne Keipert Molecular...
Fibroblast growth factor 21 (FGF21) was recently discovered as stress-induced myokine during mitochondrial disease and proposed key metabolic mediator of the integrated stress response (ISR) presumably causing systemic improvements. Curiously, precise cell-non-autonomous cell-autonomous relevance endogenous FGF21 action remained poorly understood.We made use established UCP1 transgenic (TG) mouse, a model perturbations by specific decrease in muscle efficiency through increased respiratory...
Abstract Background and aims Non‐alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent nutrition intervention remains the most important therapeutic approach for NAFLD. Our aim was to investigate whether low‐ (LP) or high‐protein (HP) diets are more effective in reducing fat reversing NAFLD which mechanisms involved. Methods 19 participants with morbid obesity undergoing bariatric surgery were randomized into two hypocaloric (1500‐1600 kcal/day) diet groups, a low protein...
Mitochondrial dysfunction is usually associated with various metabolic disorders and ageing. However, salutary effects in response to mild mitochondrial perturbations have been reported multiple organisms, whereas molecular regulators of cell-autonomous stress responses remain elusive. We addressed this question by asking whether the nuclear factor erythroid-derived-like 2 (Nrf2), a transcription master regulator cellular redox status involved adaptive physiological including muscle...
Aging is accompanied by a progressive decline of muscle mass and strength also higher levels circulating cytokines such as growth differentiation factor 15 (GDF15). Studies evaluating the association GDF15 with are rare. In this analysis, we investigated concentrations their relationship in older men compared women. serum were measured 103 (60 years older) hospital patients an age-matched control group immunosorbent assay. Skeletal was determined bioelectrical impedance analysis. Grip knee...
Journal Article Controlled Trials with Trisulfapyrimidines in the Treatment of Chronic Trachoma Get access Chandler R. Dawson, Dawson Search for other works by this author on: Oxford Academic PubMed Google Scholar Lavelle Hanna, Hanna T. Rodman Wood, Wood Virginia Coleman, Coleman Odeon C. Briones, Briones Ernest Jawetz The Infectious Diseases, Volume 119, Issue 6, June 1969, Pages 581–590, https://doi.org/10.1093/infdis/119.6.581 Published: 01 1969 history Received: 14 December 1968
In the present investigation, we examined whether a change in whole body energy fluxes could affect ovarian follicular development, employing mice ectopically expressing uncoupling protein 1 skeletal muscle (UCP1-TG). Female UCP1-TG and wild-type (WT) were dissected at age of 12 weeks. Energy intake expenditure, activity, weight length, composition measured. Plasma insulin, glucose, leptin, plasma fibroblast growth factor 21 (FGF21) insulin-like (IGF1) levels analyzed follicle corpus luteum...
Abstract Recent research has identified growth differentiation factor 15 (GDF15) as a crucial in various physiological and pathological processes, particularly energy balance regulation. While the role of GDF15 modulating metabolism through hindbrain GDNF family receptor alpha-like (GFRAL) signaling been extensively studied, emerging evidence suggests direct peripheral metabolic actions GDF15. Using knockout mouse models, we investigated GFRAL’s roles adipose tissue metabolism. Our findings...
Chronic inflammation acts as a contributing factor in the development of age-related sarcopenia. Growth differentiation 15 (GDF15) is induced various tissues due to and oxidative stress (Unsicker et al., 2013). The aim study was evaluate association between GDF15, sarcopenia functional parameters geriatric patients healthy old controls. Serum GDF15 quantified with ELISA-kits. Bioelectrical impedance analysis used estimate skeletal muscle mass (SM, kg) SM-index (SMI, kg/m2). Sarcopenia...
Effects of a Protein Optimized Diet Combined with Moderate Resistance Training on the Postoperative Course in Older Patients Hip Fracture
The hormonal mediator fibroblast growth factor 21 (FGF21) is promptly induced by short fasting periods in animal models to regulate glucose and fat metabolism (Inagaki et al. 2007). Data on FGF21 humans are controversial has not yet been investigated geriatric patients with loss of appetite ongoing weight loss. We aimed explore the association cachexia old a healthy control group. Serum levels were measured commercial ELISA-kits. Cachexia was defined as ≥5% last three months (Evans al.,...