A5059680487- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Advanced X-ray and CT Imaging
- Lung Cancer Treatments and Mutations
- MRI in cancer diagnosis
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Ultrasound and Hyperthermia Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Radiation Detection and Scintillator Technologies
- HER2/EGFR in Cancer Research
- Head and Neck Cancer Studies
- Synthesis and Biological Evaluation
- Peptidase Inhibition and Analysis
University of Alabama at Birmingham
2015-2025
University of Michigan–Ann Arbor
2022
Varian Medical Systems (United States)
2021
Purdue University West Lafayette
2019
Zhejiang Hospital
2017-2019
University of Alabama
2007-2017
China University of Petroleum, Beijing
2017
Orano (United States)
2015
Hospital Clínica Benidorm
2015
University of Alberta
2012
TM-601 binds to malignant brain tumor cells with high affinity and does not seem bind normal tissue. Preclinical studies suggest that iodine-131 (131I) -TM-601 may be an effective targeted therapy for the treatment of glioma. We evaluated safety, biodistribution, dosimetry intracavitary-administered 131I-TM-601 in patients recurrent glioma.Eighteen adult (17 glioblastoma multiforme one anaplastic astrocytoma) histologically documented glioma a Karnofsky performance status > or = 60% who were...
PURPOSE Lym-1, a monoclonal antibody that preferentially targets malignant lymphocytes, has induced remissions in patients with non-Hodgkin's lymphoma (NHL) when labeled iodine 131 ((131)I). Based on the strategy of fractionating total dose, this study was designed to define maximum-tolerated dose (MTD) and efficacy first two, maximum four, doses (131)I-Lym-1 given 4 weeks apart. Additionally, toxicity radiation dosimetry were assessed. MATERIALS AND METHODS Twenty advanced NHL entered 21...
Purpose: Study distribution, pharmacokinetics, and safety of intraperitoneal (IP) 212Pb-TCMC-trastuzumab in patients with HER-2-expressing malignancy. Experimental Design: IP was delivered, after 4 mg/kg intravenous (IV) trastuzumab, to 3 cancer who had failed standard therapies. Patients were monitored for toxicity pharmacokinetics/dosimetry parameters. Results: Imaging studies 0.2 mCi/m2 (7.4 MBq/m2) show little redistribution out the peritoneal cavity no significant uptake major organs....
Our purpose was to study the safety, distribution, pharmacokinetics, immunogenicity, and tumor response of intraperitoneal <sup>212</sup>Pb-TCMC-trastuzumab (TCMC is S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbamoylmethyl)cyclododecane) in patients with human epidermal growth factor receptor type 2 (HER-2)–expressing malignancy. <b>Methods:</b> In a standard 3 + phase 1 design for dose escalation, delivered intraperitoneally less than 4 h after administration...
Intensity modulated radiation therapy (IMRT) with a dynamic multileaf collimator (DMLC) requires synchronization of DMLC leaf motion dose delivery. A delay in communication is known to cause lag and lead dosimetric errors. The errors may be exacerbated by gated operation. purpose this study was investigate the effect on accuracy doses delivered IMRT. We first determined effective time measuring stationary phantom wedge-shaped fields. wedge fields were generated at various rates. so varied...
Abstract We recently identified CD46 as a novel prostate cancer cell surface antigen that shows lineage independent expression in both adenocarcinoma and small neuroendocrine subtypes of metastatic castration resistant (mCRPC), discovered an internalizing human monoclonal antibody YS5 binds to tumor selective epitope, developed microtubule inhibitor-based drug conjugate is multi-center phase I trial for mCRPC (NCT03575819). Here we report the development CD46-targeted alpha therapy based on...
Absorbed-dose calculations provide a scientific basis for evaluating the biologic effects associated with administered radiopharmaceuticals. In cancer therapy, radiation dosimetry supports treatment planning, dose-response analyses, predictions of therapy effectiveness, and completeness patient medical records. this study, we evaluated organ absorbed doses from intravenously (111)In- (90)Y-ibritumomab tiuxetan.Ten patients (6 men 4 women) non-Hodgkin lymphoma, cared at 3 different centers,...
While endoscopic ultrasound (EUS)-guided fiducial placement is technically feasible, its role in the delivery of image-guided radiation therapy (IGRT) unclear. In this study, we evaluated feasibility and safety using EUS-guided markers for delivering IGRT patients with pancreatic cancer. Following computed tomography (CT) simulation, a treatment plan was prepared each patient. A kilovoltage (kv) image obtained before session aligned images generated during planning, based on position...
Abstract Purpose/objectives Recent technological advancements have increased efficiency for clinical deliverability of online‐adaptive‐radiotherapy (oART). Previous cone‐beam‐computed‐tomography (CBCT) generations lacked the ability to provide reliable Hounsfield‐units (HU), thus requiring oART workflows rely on synthetic‐CT (sCT) images derived through deformable‐image‐registration (DIR) between planning CT (pCT) and daily CBCT. These sCTs are prone errors stemming from DIR, potentially...
This trial was conducted to assess the toxicity and efficacy of 131I-Lym-1 in patients with either malignant B-cell non-Hodgkin's lymphoma (NHL) or chronic lymphocytic leukemia (CLL) using low-dose, fractionated radioimmunotherapy (RIT).Thirty adult who had advanced malignancies (25 NHL 5 CLL) progressed despite standard therapy; 12 entered Karnofsky performance status (KPS) equal greater than 60. Patients were treated a series intravenous doses goal reaching cumulative dose each patient at...
Although radioimmunotherapy alone is effective in lymphoma, its application to solid tumors will likely require a combined modality approach. In these phase I studies, paclitaxel was with patients metastatic hormone-refractory prostate cancer or advanced breast cancer.Patients were imaged indium-111 (111In)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-peptide-m170. One week later, yttrium-90 (90Y)-m170 infused (12 mCi/m2 for and 22 cancer). Initial cohorts received alone....
Respiratory motion can introduce substantial dose errors during IMRT delivery. These are difficult to predict because of the nonsynchronous interplay between radiation beams and tissues. The present study investigates impact fractionation on respiratory induced dosimetric delivery their radiobiological implications by using measured 3D dose. We focused with dynamic multileaf collimation (DMLC‐IMRT). plans several beam arrangements were optimized for delivered a polystyrene phantom containing...