A5040576127- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Alcohol Consumption and Health Effects
- Cardiac Arrest and Resuscitation
- Diet and metabolism studies
- Nosocomial Infections in ICU
- Neurosurgical Procedures and Complications
- Electromagnetic Fields and Biological Effects
- Epigenetics and DNA Methylation
- Diabetes and associated disorders
- Advanced Glycation End Products research
- Dementia and Cognitive Impairment Research
- Chromatin Remodeling and Cancer
- Ovarian function and disorders
- Obesity, Physical Activity, Diet
- Organ and Tissue Transplantation Research
- Microbial Inactivation Methods
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipid metabolism and disorders
- Thermoregulation and physiological responses
Air Force Medical University
2013-2025
Xijing Hospital
2018-2022
Dysregulation of transcription factors (TFs) is associated with tumor progression, but little known about TF expression patterns in the context gastric cancer (GC) metastasis. Using array-based profile analysis, we found that 22 TFs showed differential activities between GC cell lines low- and high-metastatic potential. Of this group TFs, serum response factor (SRF) was significantly upregulated metastatic cells. SRF frequently elevated a panel cells tissues, high-level more aggressive...
Abstract Background Sepsis-associated encephalopathy (SAE) is related to increased short-term mortality in patients with sepsis. We aim establish a user-friendly nomogram for individual prediction of 30-day risk SAE. Methods Data were retrospectively retrieved from the Medical Information Mart Intensive Care (MIMIC III) open source clinical database. SAE was defined by Glasgow Coma Score (GCS) < 15 or delirium at presence Prediction model constructed training set logistic regression...
Abstract Background The role of stress hyperglycemia ratio (SHR) on the prognosis spontaneous intracerebral hemorrhage (ICH) in patients with different diabetic status has not been elucidated. This study aimed to evaluate prognostic value SHR and admission blood glucose (ABG) for short- long-term mortality nondiabetic populations ICH. Method Participants ICH were retrospectively retrieved from Medical Information Mart Intensive Care (MIMIC-IV). primary outcome was all-cause 30-day 1-year...
Abstract Background The correlation between the triglyceride-glucose index (TyG) and prognosis of ischemic stroke has been well established. This study aims to assess influence TyG on clinical outcomes critically ill individuals suffering from intracerebral hemorrhage (ICH). Methods Patients diagnosed with ICH were retrospectively retrieved Medical Information Mart for Intensive Care (MIMIC-IV) eICU Collaborative Research Database (eICU-CRD). Various statistical methods, including restricted...
Episodic memory decline is a common complication of type 2 diabetes (T2D). To comprehensively explore the neural mechanisms underlying it, we aimed to sequence that episodic memory-related behavioral and brain-imaging biomarkers appear abnormal in progression T2D. We enrolled 62 healthy controls 110 patients with The California Verbal Learning Test, Montreal cognitive assessment, Stroop color word test was used assess memory, general function, executive function. Principal component analysis...
Sex differences in the incidence of thyroid nodules (TNs) are broadly recognized, but further analysis is lacking. Thus, aim this study was to evaluate association between TNs and anthropometric parameters type 2 diabetic males females. This cross-sectional included 747 patients with diabetes mellitus (T2DM). All underwent clinical examination, ultrasound, laboratory tests, anthropometrics body composition. Multivariable logistic regression assessed factors associated TNs, a simple nomogram...
ObjectiveTo develop an orthotopic, allogeneic, uterine transplantation technique and effective immunosuppressive protocol in the sheep model. MethodsIn this pilot study, 10 sexually mature ewes were subjected to laparotomy total abdominal hysterectomy with oophorectomy procure uterus allografts. The cold ischemic time was 60 min. End-to-end vascular anastomosis performed using continuous, non-interlocking sutures. Complete tissue reperfusion achieved all animals within 30 s after...
Abstract Growing evidence has shown that pulsed electromagnetic fields (PEMF) can modulate bone metabolism in vivo and regulate the activities of osteoblasts osteoclasts vitro. Osteocytes, accounting for 95% cells, act as major mechanosensors transducing external mechanical signals producing cytokines to osteoblastic osteoclastic activities. Targeting osteocytic signaling pathways is becoming an emerging therapeutic strategy diseases. We herein systematically investigated changes osteocyte...
To explore the relationship between serum uric acid (UA) and high-density lipoprotein cholesterol (HDL-C) ratio (UHR) metabolic syndrome (MetS) in nondiabetic individuals.A total of 15,760 participants were screened from China National Diabetes Metabolic Disorders Study. Pearson correlation was used to determine components MetS UHR, HDL-C, UA. Receiver operating characteristic curves evaluate ability UA identify population.A 6,386 men 9,374 women enrolled this study. There 1,480 (23.2%)...
Both protective and therapeutic functions of insulin-like growth factor-1 (IGF-1) in brain injury have been reported, but its effects on cognitive sequelae after septic encephalopathy (SE) remain unclear.This study was divided into three parts, a model built by cecal ligation puncture (CLP). First, survival analysis performed, IGF-1's long-term cognition depressive emotion were assessed. Second, the characteristics IGF-1 function evaluated. Finally, cytochrome C, caspase-9, tumor necrosis...
Abstract Aims Glycated albumin (GA) is a biomarker for short‐term (2–3 weeks) glycaemic control. However, the predictive utility of GA diabetes and prediabetes largely uncharacterised. We aimed to investigate relationships baseline serum levels with incident prediabetes. Methods This was longitudinal cohort study involving 516 subjects without or at baseline. Blood glucose were observed during follow‐up. Hazard ratios (HRs) 95% confidence intervals (CIs) calculated using COX proportional...
Hepatoma‑derived growth factor (HDGF) regulates various cellular processes involved in the onset and development of tumors. To evaluate role HDGF human gliomas, western blotting analysis, immunohistochemistry staining reverse transcription‑quantitative polymerase chain reaction were performed to detect protein mRNA expression levels glioma intractable epileptic brain tissue. Various clinicopathological characteristics, including age, gender, World health Organization grade, level, Karnofsky...
Abstract Purpose Metabolic syndrome (Mets) is a pathological condition that includes many abnormal metabolic components and requires simple detection method for rapid use in large population. The aim of the study was to develop diagnostic model Mets Chinese population with noninvasive anthropometric demographic predictors. Patients methods Least absolute shrinkage selection operator (LASSO) regression used screen A sample from China National Diabetes Disorders Survey (CNDMDS) logistic...
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<title>Abstract</title> This research aimed to investigate the association between various anthropometric indexes and metabolic syndrome (MetS) evaluate their predictive effectiveness for MetS. Data from China National Diabetes Metabolic Disorders Survey (CNDMDS) were analyzed, including 44,557 adults aged 20 years above. Eleven assessed with prevalence of MetS diagnosis was based on Joint Interim Statement (JIS) criteria, discriminatory ability each index evaluated using receiver operating...
Background/Objectives: This study aims to investigate the effects of 4-methylumbelliferone (4-MU) on islet morphology, cell phenotype and function, explore possible mechanisms β regeneration. Methods: The Type 1 diabetes (T1D) model was induced by continuous dose injection streptozotocin (STZ), mice were treated with 4-MU for 3 weeks. Plasma insulin level, immune infiltration determined IPGTT, ELISA, HE immunofluorescence. Ins2Cre/+/Rosa26-eGFP transgenic used detect identity change. Primary...
DACH1 is an important component of the retinal determinate gene network (RDGN), which regulates expression target genes by directly binding or interacting with other factors. shows inhibitory effects in most tumors, but its role papillary thyroid carcinoma unclear and warrants further investigation. We assessed different tissues correlation immune infiltration The Cancer Genome Atlas (TCGA) Tumor Immune Estimation Resource (TIMMER2.0 databases). on proliferation migration TPC-1 Bcpap cells...
Liang, Sheng-Ru; Cai, Jing; Yang, Yang; Zhang, Lei; Taylor, Peter; Ming, Jie; Yu, Xin-Wen; Hu, Ruo-Fan; Zhou, Da-Yan, Colin M.; Ji, Qiu-HeEditor(s): Guo, Li-Shao Author Information
Abstract Background & Aims: Although many studies have shown that non-alcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes mellitus (T2DM), no cohort study has explored the relationship between histopathological grade of NAFLD and risk T2DM in patients. We aimed to explore whether a higher concentration cytokeratin-18 (CK-18), as reliable marker hepatic fibrosis, was greater patients NAFLD. Methods: The population-based based on China National Diabetes Metabolic...
Abstract BackgroundThe over-consumption of time for data collection in the Sequential Organ Failure Assessment (SOFA) score and poor performance quickSOFA (qSOFA) predicting prognosis among patients with suspected infection intensive care unit (ICU) may delay treatment towards sepsis. The aim this study is to develop a prediction model early identify who are under high risk in-hospital mortality ICU.MethodsPatients were retrospectively retrieved from Medical Information Mart Intensive Care...
Abstract Background Sepsis-associated encephalopathy (SAE) is related to an increased in-hospital mortality in patients with sepsis. We aim establish a user-friendly nomogram for individual prediction of death probability SAE. MethodsData were retrospectively retrieved from the Medical Information Mart Intensive Care (MIMIC III) open source clinical database. SAE was defined by Glasgow Coma Score (GCS) <15 at presence Prediction model constructed training set Logistic regression analysis...
Abstract Background: Sepsis-associated encephalopathy (SAE) is related to an increased in-hospital mortality in patients with sepsis. We aim establish a user-friendly nomogram for individual prediction of death probability SAE.Methods: Data were retrospectively retrieved from the Medical Information Mart Intensive Care (MIMIC III) open source clinical database. SAE was defined by Glasgow Coma Score (GCS) <15 at presence Prediction model constructed training set Logistic regression...
Abstract Background Conscious impairment is related to worse prognosis in patients with sepsis. we aimed evaluate the impact of conscious disorder on 30-day mortality sepsis and identify remediable risk factors for it. Methods Data were retrospectively retrieved from a prospective intensive care database. was assessed by Glasgow Coma Score (GCS). The dysfunction its potentially modifiable evaluated using Cox proportional hazard regression logistic regression, respectively. Results A total...