A5100668612- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Calpain Protease Function and Regulation
- Caveolin-1 and cellular processes
- Milk Quality and Mastitis in Dairy Cows
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Diet and metabolism studies
- Industrial Vision Systems and Defect Detection
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Magnesium Oxide Properties and Applications
- Chemical Synthesis and Analysis
- Coal Combustion and Slurry Processing
- Biochemical and Structural Characterization
- Extracellular vesicles in disease
- Glutathione Transferases and Polymorphisms
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
China University of Mining and Technology
2025
North China Electric Power University
2025
Shenzhen Technology University
2025
Wuxi People's Hospital
2023
Jiangxi Agricultural University
2023
Nanjing Drum Tower Hospital
2023
National Clinical Research Center for Digestive Diseases
2023
University of Science and Technology Beijing
2021
Shenyang Pharmaceutical University
2014-2018
Wuhan University of Technology
2018
Leukemic stem cells (LSCs) isolated from acute myeloid leukemia (AML) patients are more sensitive to nuclear factor κB (NF-κB) inhibition-induced cell death when compared with hematopoietic and progenitor (HSPCs) in vitro culture. However, inadequate anti-leukemic activity of NF-κB inhibition vivo suggests the presence additional survival/proliferative signals that can compensate for inhibition. AML subtypes M3, M4, M5 produce endogenous tumor necrosis α (TNF). Although stimulating HSPC TNF...
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine calpains, autophagy, endoplasmic reticulum (ER) stress, apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed ER stress induced by Earle’s balanced salt solution (EBSS) through starvation to induce metabolic stress. Secondly, inhibition 4-phenyl butyric acid...
Natural coumarins represent a diverse group of secondary metabolites with wide range biological activities. However, their specific molecular targets have remained largely unexplored. Employing chemical proteomics, comprehensive analysis the protein natural coumarin fraxetin has been conducted. Prostaglandin reductase 2 (PTGR2), key enzyme involved in final inactivation prostaglandins, was identified as primary target fraxetin. Inhibition PTGR2 can lead to accumulation 15-keto-PGE2, which...
Abstract Safe and standardized power maintenance repair is an essential part of ensuring the stable operation electricity also important way to protect personal safety personnel. Therefore, detect actions better improve target detection accuracy in overhaul maintenance, this paper proposes enhanced YOLOv5s algorithm based on Convolutional Block Attention Module (CBAM) attention mechanism. This adopts Mosaic9 data augmentation technique a distance‐based non‐maximum suppression replace...
ABSTRACT Blood–brain tumor barrier (BTB) impedes the transportation of antitumor therapeutic drugs into brain tumors. Its mechanism is still unknown, but learning how to improve BTB permeability critical for drug intervention. Recently, microRNAs (miRNAs) have appeared as regulation factors numerous biologic processes and targets diverse diseases. In this study, we identified that miR‐132‐3p an essential miRNA by increasing transcellular transport through BTB. We found expression was...
Deregulation of Nuclear Transcription Factor-κB (NF-κB) and Jun N-terminal kinase (JNK) signaling is commonly detected in leukemia, suggesting an important role for these two pathways the pathogenesis leukemia. In this study, using Jurkat cells, acute T-lymphoblastic leukemia (T-ALL) cell line, we evaluated effects NF-κB inhibitor a JNK individually combination on proliferation, survival clonogenic capacity leukemic cells. We found that stem/progenitor cells (LSPCs) were more sensitive to...
Sodium-coupled neutral amino acid transporter 2 (SNAT2) belongs to solute carrier 38 (SLC38) family of transporters, which is ubiquitously expressed in mammalian tissues and mediates transport small, acids, exemplified by alanine(Ala, A). Yet structural data on SNAT2, including the relevance intrinsic cysteine residues structure function, scarce, spite its essential roles many tissues. To better define potential cysteines form disulfide bonds mutagenesis experiments thiol-specific chemical...
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are key transmembrane proteins leading to reactive oxygen species (ROS) overproduction. However, the detailed roles of NOXs in retinal pigment epithelial (RPE) cell metabolic stress induced by Earle's balanced salt solution (EBSS) through starvation remain unclear. In this study, we investigated what play regard calpain activity, endoplasmic (ER), autophagy, and apoptosis during ARPE-19 cells. We first found that EBSS an...
Abstract To further understand the role of three conserved Val residues in insulin, B12Val, B18Val, and A3Val, five insulin mutants‐‐[A3Ser]insulin, [B12Thr]insulin, (desB30)[B12Ser]insulin, [B18Thr] [B18Leu]insulin‐‐were obtained by means site‐directed mutagenesis their receptor‐binding activities as well vivo biological potencies were measured. The two B18 mutants, [B18Thr]insulin [B18Leu]insulin, both retained relatively high (70% 30% native porcine respectively) potencies....
Mg 0.27 Al 2.58 O 3.73 N 透明陶瓷机械性能评价 张 舟, 王 皓, 涂兵田, 徐鹏宇, 王为民, 傅正义 (武汉理工大学 材料复合新技术国家重点实验室, 武汉 430070) 摘 要: MgAlON 透明陶瓷具有优良的光学与机械性能, 在军用和民用领域均具有重要的应用潜力。本研究表征并 评价了 透明陶瓷的机械性能, 实验测定了 透明陶瓷的维氏硬度、 断裂韧性 以及室温和高温断裂强度, 并使用 Weibull 函数对室温断裂强度测试结果进行统计。结果表明: 该透明陶瓷特征断裂强 度为 255 MPa、断裂韧性为 2.56 MPa/m 1/2 、杨氏模量为 288 GPa、硬度为 15.1 GPa。样品的 模数为 4.5, 1200℃ 下样品断裂强度达 125 MPa。同时还测定了不同载荷下 0.
Esophageal, gastric, liver, and colorectal cancers represent four prevalent gastrointestinal that pose substantial threats to global health due their high morbidity mortality rates.Peroxiredoxin 1 (PRDX1), a significant component of the PRDXs family, primarily functions counteract peroxides produced by metabolic activities in body, thereby maintaining dynamic equilibrium vivo.Intriguingly, PRDX1 expression correlates strongly with cancer's onset, progression, prognosis.This study mainly...