A5060817706- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Neural dynamics and brain function
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Neuroscience and Neural Engineering
- Lipid Membrane Structure and Behavior
- Neurological Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Advanced Memory and Neural Computing
- Cancer, Hypoxia, and Metabolism
- Machine Learning in Healthcare
- Hereditary Neurological Disorders
- Stroke Rehabilitation and Recovery
- Autophagy in Disease and Therapy
- Visual perception and processing mechanisms
- ECG Monitoring and Analysis
- Non-Invasive Vital Sign Monitoring
- Neurological Disorders and Treatments
- Neurological disorders and treatments
First Hospital of Qinhuangdao
2017-2025
Abstract Monocarboxylate transporter‐4 ( MCT 4), a monocarboxylic acid transporter, demonstrates significantly increased expression in the majority of malignancies. We performed an experiment using BALB /C mice, and our results showed that Sh 4 transfection or pharmaceutic inhibition with 7acc1 strengthens activity NK cells. The calcein assay revealed cytotoxicity cells was strengthened via 4. In addition, ELISA testing content perforin CD 107a increased, PCR amplification immunoblotting NKG...
Abstract Mild cognitive impairment (MCI) is the initial phase of Alzheimer’s disease (AD). The decline linked to abnormal connectivity between different regions brain. Most brain network studies fail consider changes in patterns and do not reflect dynamic pathological characteristics patients. Therefore, this paper proposes a method for constructing networks based on microstate sequences. It also analyzes temporal parameters introduces new feature, homeostasis coefficient (Bhc), quantify...
Rheumatoid arthritis (RA) patients have accelerated atherosclerosis (AS) leading to excess cardiovascular morbidity and mortality, but traditional risk factors for disease (CVD) are invalid explain the problem. Sulfatides, as major components of serum lipoproteins, synthesized in liver. These molecules reported play an important role development AS, thrombogenesis, inflammation. However, it is unclear whether sulfatides responsible such issue. To elucidate possible association between...
Abstract Focal seizures are a type of epileptic event that has plagued the medical community for long time, and existing drug treatment is mainly based on modulation ${GABA}_a$-receptors to affect GABAergic signaling achieve therapeutic purpose. The majority research currently focuses impact neuronal firing, failing analyze molecular ionic mechanisms involved. Specifically, deeper-level how firing by altering ion activity not been addressed. This aimed study effects different...
Orientation selectivity, as an emergent property of neurons in the visual cortex, is critical importance processing information. Characterizing orientation selectivity based on neuronal firing activities or local field potentials (LFPs) a hot topic current research. In this paper, we used cross-frequency coupling and least absolute shrinkage selection operator (LASSO) to predict grating orientations V1 V4 two rhesus monkeys. The experimental data were recorded by utilizing chronically...
The recurrent neural network architecture improves the processing ability of time-series data. However, issues such as exploding gradients and poor feature extraction limit its application in automatic diagnosis mild cognitive impairment (MCI). This paper proposed a research approach for building an MCI diagnostic model using Bayesian-optimized bidirectional long short-term memory (BO-BiLSTM) to address this problem. was based on Bayesian algorithm combined prior distribution posterior...
In order to fully explore the neural oscillatory coupling characteristics of patients with mild cognitive impairment (MCI), this paper analyzed and compared strength for 28 MCI 21 normal subjects under six different-frequency combinations. The results showed that difference in global phase synchronization index cross-frequency δ-θ rhythm combination was statistically significant group control ( P = 0.025, d 0.398). To further validate feature, proposed an optimized convolutional network...
Steroids have been used for the treatment of Guillain-Barre Syndrome (GBS) since 1950s, while their clinical efficacy remains poorly defined. Most randomized controlled trials after 1970s yielded no clues significant differences between steroid therapy and symptomatic supportive therapy, adjusting factors that affected biases, reanalysis two with largest number samples among them showed intravenous methylprednisolone was superior to or its combination immunoglobulin exhibited effects. To...
miR-1 can affect the proliferation of various cancer cells but its effect on bone marrow mesenchymal stem (BMSCs) has not been reported. This study cultured BMSCs with glioma to investigate effects BMSCs. were co-cultured using Transwell chamber, and (MSCs) transfected mimics or miR-NC (miR-Ctrl) followed by analysis cell CCK8, expression real-time PCR, NF- B p65 protein level Western blot. MSCs number was significantly increased after transfection. Cell in experimental group blank elevated...