A5064589732- SARS-CoV-2 and COVID-19 Research
- Pesticide Residue Analysis and Safety
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Analytical chemistry methods development
- Parkinson's Disease Mechanisms and Treatments
- Dental Research and COVID-19
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Neurodegenerative Diseases
- Antimicrobial Peptides and Activities
- Animal Virus Infections Studies
- Biosimilars and Bioanalytical Methods
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Per- and polyfluoroalkyl substances research
- Environmental Toxicology and Ecotoxicology
- Cytokine Signaling Pathways and Interactions
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Biosensing Techniques and Applications
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Analytical Chemistry and Chromatography
- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
Rutgers New Jersey Medical School
2021-2023
Rutgers, The State University of New Jersey
2020-2023
University of Alabama
2016-2018
China Agricultural University
2009-2013
Jiangnan University
2006-2009
Innate immunity during acute infection plays a critical role in the disease severity of severe respiratory syndrome (SARS) and Middle East (MERS), is likely to contribute COVID-19 outcomes. Defensins are highly abundant innate immune factors neutrophils epithelial cells, including intestinal Paneth exhibit antimicrobial immune-modulatory activities. In this study, we investigated effects human α- β-defensins RC101, θ-defensin analog, on SARS-CoV-2 infection. We found that neutrophil peptides...
Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) is detectable in saliva from asymptomatic individuals, suggesting a potential benefit the use of mouth rinses to suppress viral load and reduce virus spread. Published studies on reduction SARS-CoV-2-induced cytotoxic effects by do not exclude antiseptic rinse-associated cytotoxicity. Here, we determined effect commercially available povidone-iodine infectivity replication-competent SARS-CoV-2 viruses pseudotyped viruses. We...
A general and broad class selective competitive enzyme-linked immunosorbent assay (ELISA) for the detection of alpha-cyano pyrethroids was developed. One specific hapten, 5-(3-benzylphenyl)-5-cyanopentanoic acid (CPBA-BE), conjugated with BSA as an immunogen. Polyclonal antibodies, PY-antibodies, were generated. The most selectivity family such cyphenothrin further optimized tested tolerance to cosolvent, pH, ionic strength changes. IC(50) values immunoassay 4.58 microg L(-1) cyphenothrin,...
We probed the role of alpha-synuclein (α-syn) in modulating sorting nexin 3 (Snx3)-retromer-mediated recycling iron transporters Saccharomyces cerevisiae and Caenorhabditis elegans. In yeast, membrane-bound heterodimer Fet3/Ftr1 is high affinity importer. Fet3 a multicopper ferroxidase, whose ferroxidase domain orthologous to human ceruloplasmin (Cp), that oxidizes external Fe+2 Fe+3; Fe+3 ions then channel through Ftr1 permease into cell. When concentration low (<1 µM), maintained on plasma...
Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent of disease 19 (COVID-19), enters cells through attachment to human angiotensin converting enzyme 2 (hACE2) via receptor-binding domain (RBD) in surface/spike (S) protein. Several pseudotyped viruses expressing SARS-CoV-2 S proteins are available, but many these can only infect hACE2-overexpressing cell lines. Here, we report use a simple, two-plasmid, virus system comprising spike-expressing plasmid and...
In this study, a gas chromatography—mass spectrometry method is successfully developed for the determination of 11 herbicide residues (alachlor, acetochlor, butachlor, pretilachlor, metolachlor, dimethenamid, propachlor, napropamid, propanil, atrazine, and metribuzin) in rice soybeans. The sample extracted with acetone—water, degreased by liquid—liquid partition, purified through solid-phase extraction Florisil. Experiments on 5 fortification concentrations are carried out, limit 0.02 mg/kg....
The discovery of new safe and effective pesticides is one the main means providing eco-friendly agricultural agents for modern crop protection. To identify biological molecules based anthranilic diamide skeleton novel pesticide chlorantraniliprole, which acts on ryanodine receptor functional groups in acyl hydrazine insect growth regulators, more than 40 compounds 2-acylamino-substituted N'-benzylbenzohydrazide derivatives were designed synthesized. structures characterized using (1)H...
Abstract SARS-CoV-2 is detectable in saliva from asymptomatic individuals, suggesting a potential benefit the use of mouth rinses to suppress viral load and reduce virus spread. Published studies on reduction SARS-CoV-2-induced cytotoxic effects by antiseptics do not exclude antiseptic-associated cytotoxicity. Here, we determined effect commercially available antiseptic povidone-iodine infectivity non-pathogenic, recombinant, infection vector (pseudotyped virus). We first cell viability...
We have been investigating the role that phosphatidylethanolamine (PE) and phosphatidylcholine (PC) content plays in modulating solubility of Parkinson's disease protein alpha-synuclein (α-syn) using Saccharomyces cerevisiae Caenorhabditis elegans. One enzyme synthesizes PE is conserved phosphatidylserine decarboxylase (Psd1/yeast; PSD-1/worms), which lodged inner mitochondrial membrane. previously found decreasing level due to knockdown Psd1/psd-1 affects homeostasis α-syn vivo. In S....
Abstract Interferon ɛ (IFNɛ) is a unique type I IFN that has been implicated in host defense against sexually transmitted infections. Zika virus (ZIKV), an emerging pathogen, can infect the female reproductive tract (FRT) and cause devastating diseases, particularly pregnant women. How IFNɛ contributes to protection ZIKV infection vivo unknown. In this study, we show plays critical role vaginal mice. We found was expressed not only by epithelial cells FRT but also immune stromal at baseline...
Tetrabromobisphenol A (TBBPA) has been an important brominated flame retardant worldwide and become a widely concerned environmental pollutant due to its persistence in the environment. In this study, monoclonal antibody (MAb, designated 3D9G6) against TBBPA was produced, indirect competitive enzyme-linked immunoassay (icELISA) for detecting trace developed. The limit of detection half maximum inhibition concentration phosphate-buffered saline were 0.8 3.87 ng·mL−1, respectively. assay...
The oral cavity is thought to be one of the portals for SARS-CoV-2 entry, although there limited evidence active infection by viruses. We assessed capacity infect and replicate in epithelial cells. Oral gingival cells (hTERT TIGKs), salivary gland (A-253), buccal (TR146), which occupy different regions cavity, were challenged with replication-competent viruses pseudo-typed expressing spike proteins. All undetectable or low levels human angiotensin-converting enzyme 2 (hACE2) but high...