A5101519159- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Environmental Toxicology and Ecotoxicology
- Membrane Separation Technologies
- FOXO transcription factor regulation
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Zebrafish Biomedical Research Applications
- Inflammasome and immune disorders
- Chemical synthesis and pharmacological studies
- Plant Gene Expression Analysis
- Membrane-based Ion Separation Techniques
- Fungal and yeast genetics research
- GABA and Rice Research
- Flavonoids in Medical Research
- Extraction and Separation Processes
- Heat shock proteins research
- Tissue Engineering and Regenerative Medicine
- Streptococcal Infections and Treatments
- Enzyme-mediated dye degradation
- Solar-Powered Water Purification Methods
- Pesticide and Herbicide Environmental Studies
- Neonatal and Maternal Infections
Xinxiang Medical University
2017-2025
Xi'an University of Architecture and Technology
2024
Universiti Sains Malaysia
2020-2023
Southwest University of Science and Technology
2023
Joint Laboratory for Extreme Conditions Matter Properties
2023
ShenZhen People’s Hospital
2020
Henan Radio and Television University
2013
Guangdong Medical College
2010-2011
Nankai University
2010
Tiangong University
2010
The transcriptional repressor FOXN3 plays a key role in regulating pulmonary inflammatory responses, which are crucial the development of fibrosis. However, its specific regulatory function lung fibrosis remains unclear. Here, we show that suppresses by inhibiting Smad activity. targets substantial number response gene promoters, facilitating Smad4 ubiquitination, disrupts association Smad2/3/4 complex with chromatin and abolishes response. In to pro-fibrotic stimuli, NEK6 phosphorylates at...
Abstract NF-κB activates the primary inflammatory response pathway responsible for methicillin-resistant Staphylococcus aureus (MRSA)-induced lung inflammation and injury. Here, we report that Forkhead box transcription factor FOXN3 ameliorates MRSA-induced pulmonary injury by inactivating signaling. competes with IκBα binding to heterogeneous ribonucleoprotein-U (hnRNPU), thereby blocking β-TrCP-mediated degradation leading inactivation. is directly phosphorylated p38 at S83 S85 residues,...
Mesenchymal stem cells regulate remote intercellular signaling communication via their secreted extracellular vesicles. Here, we report that menstrual blood-derived alleviate acute lung inflammation and injury vesicle-transmitted miR-671-5p. Disruption of this abundantly expressed miR-671-5p dramatically reduced the ameliorative effect vesicles released by on lipopolysaccharide (LPS)-induced pulmonary inflammatory injury. Mechanistically, directly targets kinase AAK1 for post-transcriptional...
Abstract In this paper, we evaluated the acute toxicity of five naphthoquinone compounds, expressed as median lethal concentration at 96 h (LC50) using zebrafish a model. The compounds were classified harmful or very toxic. Gaussian method was used to calculate quantitative-chemical parameters each compound. Based on structure-activity relationship analysis, interaction between naphthoquinones and target is likely mediated by 1-carbonyl hydrophobic fraction substituted in α -position via...
To discuss the protective effect of bone marrow mesenchymal stem cell (BMSC) on lung injury induced by vibrio vulnificus sepsis and its mechanism.BMSCs were isolated whole adherent culture from mouse. Male ICR mice randomly divided into normal saline control group (NS group), + BMSC (NSB (VV (VVB group) according to random number table, with 40 in each group. Sepsis mouse model was reproduced injecting (1 × 10⁷ cfu/mL) 5 mL/kg through left side peritoneal cavity, caudal intravenous injection...
The small ubiquitin-like modifier (SUMO) modification occurred at bud necks and sites of septum formation in hyphae the opportunistic fungal pathogen Candida albicans. Three genes encoding putative SUMO deconjugation enzymes (Ulp, protein specific proteases) C. albicans were obtained through sequence database searching with Ulp domain Saccharomyces cerevisiae Ulp1 (ScUlp1). These designated as CaULP1, CaULP2 CaULP3. open reading frames three ULPs cloned expressed Pichia pastoris, resulting...
The aim of the present study was to evaluate healing effect bone marrow-derived mesenchymal stem cells administered hyperglycemia model mice with skin wounds, and explore underlying mechanism contributing their effects in promoting refractory wound healing. A full‑thickness mouse established, refers a subcutaneous tissue. were randomly divided into three groups: Blank control group, hyperglycemic group treated cells. Wound monitored wound‑healing rate determined at 3, 6, 9, 12 days following...
Stem cells derived from adipose tissues (ADSCs) have emerged as an ideal candidate for various models of respiratory diseases, including asthma, Chronic Obstructive Pulmonary Disease (COPD), and acute distress syndrome. ADSCs qualities that may make them better suited treating inflammatory lung diseases than other MSCs. show a lower senescence ratio, higher proliferative capacity stability in terms their genetic morphology during long-term culture over Bone Marrow-derived Mesenchymal Cells...
In this paper, five naphthaquinones were regarded as research objects. The acute growth inhibition toxicities of on Chlorella pyrenoidosa at 72h, expressed median inhibit concentration (EC50) determined. results showed that these harmful, toxic and very to C. pyrenoidosa. active positions naphthoquinones acting the biomacromolecule maybe 1-carbonyl 2-alkyl naphthoquinone via hydrogen bond hydrophobic interaction. This study laid a foundation evaluate aquatic ecological risk toxicology mechanism
By a environmentally friendly method with the control of anionic amino acid surfactant N-lauroylsarcosine sodium (Sar-Na), hydroxyapatite (HAP) nanoplates were synthesized and adsorption behavior bovine serum albumin (BSA) carefully studied. The products characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) Fourier transform infrared spectroscopy (FTIR). Results showed that nanocrystals lengths 100 nm, width 10 nm high aspect ratio (10:1) obtained. UV-Vis spectrum...
Objective To investigate the protective effect of Baicalin on inflammation induced by lipopolysaccharide in H9C2 cardiomyocytes and its possible mechanism. Methods H9C2 myocardial cells were cultured pretreated with baicalin at final concentration 10, 20, 30 μmol/L for 12 hours, then stimulated LPS 1 μg/mL 6 hours. The control group was treated same amount saline to collect cell samples. CCK-8 (The Cell Counting Kit-8) used detect activity, enzyme-linked immunosorbent assay (ELISA)...
As a green and low-energy water treatment technology, solar-driven interface evaporation technology is widely used in seawater desalination, power generation wastewater systems. Here, we developed three-dimensional sponge as solar evaporator by using hydrophilic compounds (konjac glucomannan, KGM) absorber (copper sulfide, CuS). The achieved fast rate (1.58 kg m-2 h-1) an excellent interfacial efficiency (94.30%) under one sun. Due to the peculiarity of CuS KGM, had characteristics...
The predominant pyridine alkaloid in modern tobacco ( Nicotiana tabacum ) is Nicotine. However, with the existence of a class Nicotine demethylases, large proportion will be converted into Nornicotine during leaf senescence. Identification demethylases important, since nitrosated N'-nitrosonornicotine (NNN), which exhibit carcinogenic properties laboratory animals and harmful for human heath. Although many efforts have been performed to identified, no comprehensive analysis was carried out...
Objective To investigate the protective effect and mechanism of curcumin on acute lung injury in septic mice. Methods Totally 120 clean BALB/c male mice were randomly (random number) divided into 8 groups: sham group, sepsis control intervention negative virus-sepsis virus-curcumin Mfn2 interference-sepsis interference-curcumin 15 rats each group. Mice groups given cecal ligation puncture (CLP) 200 mg/(kg·d) for 1 week, group established by injection a adeno-associated virus tail...
Abstract Purpose: This study aimed to evaluate activity，resistance, clonality of MIC distribution, and the correlation between virulence＆resistance gene biofilm formation omadacycline (OMC) in clinical for Streptococcus agalactiae isolates from China. Methods: 162 were collected retrospectively China 2018 2019. The S. mainly body's cervical secretions, wound ear swab, semen, venous blood, cerebrospinal fluid, pee, urethral discharge, pus, umbilical reproductive tract sputum, gastric juice,...