A5102975601- Myofascial pain diagnosis and treatment
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Muscle Physiology and Disorders
- Musculoskeletal pain and rehabilitation
- Circular RNAs in diseases
- Laser Applications in Dentistry and Medicine
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Pain Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Healthcare and Venom Research
- Sports injuries and prevention
- Pain Management and Treatment
- Acupuncture Treatment Research Studies
- Spine and Intervertebral Disc Pathology
- Signaling Pathways in Disease
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mesenchymal stem cell research
- Medical and Biological Ozone Research
- Amyotrophic Lateral Sclerosis Research
- Orthopedic Surgery and Rehabilitation
- Traditional Chinese Medicine Analysis
- Workplace Health and Well-being
- Protein Degradation and Inhibitors
Huadong Hospital
2014-2025
Fudan University
2014-2025
ShanghaiTech University
2024
PLA 306 Hospital
2018
Renji Hospital
2010
There is an extensive body of research about chronic pain and treatment in developed countries. In contrast there a lack on this topic developing countries including China. This study was aimed to estimate the prevalence different regions Data its were collected from 9357 participants using questionnaires telephone-based interviews, 31 Gathered data then coded into electronic acquisition system descriptive inferential statistical analysis performed. Out 9298 participants, ratio 31.54% with...
Neuropathic pain remains a prevalent and persistent clinical problem because it is often poorly responsive to the currently used analgesics. It very urgent develop novel drugs alleviate neuropathic pain. Galectin-3 (gal3) multifunctional protein belonging carbohydrate-ligand lectin family, which expressed by different cells. Emerging studies showed that gal3 elicits pro-inflammatory response recruiting activating lymphocytes, macrophages microglia. In study we investigated whether inhibition...
Abstract Background Sarcopenia is a common skeletal disease related to myogenic disorders and muscle atrophy. Current clinical management has limited effectiveness. We sought investigate the role of miR-1290 in myoblast differentiation Methods By transfecting into C2C12 cells, we investigated whether regulates myogenesis myotube atrophy via AKT/P70 signaling pathway. MHC staining was performed assess differentiation. Differentiation-related MHC, Myod, Myog protein levels, atrophy-related...
Abstract Background Latent and active myofascial trigger points (MTrPs) in knee-associated muscles may play a key role pain management among patients with knee osteoarthritis (KOA). The aim of this study was to investigate the effect dry needling treatment on intensity, disability, range motion (ROM) KOA. Methods This randomized, single-blinded, clinical trial carried out for 6 weeks 6-month follow-up. A total 98 met entry criteria were randomly assigned latent point stretching group or oral...
Physiological adaptations to microgravity involve alterations in cardiovascular, neuromuscular, and neuroendocrine systems. These result cardiac remodeling orthostatic hypotension. At present, the mechanism of induced by remains be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an inhibitor pressure-overload down-regulation phosphorylation HDAC4. However, role CKIP-1 unknown. The purpose this study was determine whether also involved regulation microgravity. We first detected...
Abstract Muscle atrophy is a frequently observed complication, characterized by the loss of muscle mass and strength, which diminishes quality life survival. No effective therapy except exercise currently available. In our previous study, repressing miR-29b has been shown to reduce atrophy. current we have constructed artificially engineered extracellular vesicles for delivery CRISPR/Cas9 target (EVs-Cas9-29b). EVs-Cas9-29b favorable functional effect with respect repression in specific...
Abstract Background Plantar fasciitis (PF) is the most common cause of heel pain. Among conservative treatments, extracorporeal shock wave therapy (ESWT) considered effective for refractory PF. Studies have shown that applying ESWT to trigger points (TrPs) in triceps surae may play an important role pain treatment patients with Therefore, purpose this study was combine concept and explore effect combination on plantar temperature pressure Methods After inclusion exclusion criteria, 86 PF...
Abstract Little is known about if and how circular RNAs (circRNAs) are involved in skeletal muscle atrophy. Here a conserved RNA Damage‐specific DNA binding protein 1 (circDdb1), derived from the host gene encoding (DDB1), as mechanism of atrophy identified. circDdb1 expression markedly increased variety types vivo vitro, human aging muscle. Both ectopic causes In contrast, multiple forms caused by dexamethasone, tumor necrosis factor‐alpha (TNF‐α), or angiotensin II (Ang II) myotube cells,...
The treatment of plantar heel pain is highly challenging. We report ultrasound-guided pulsed radiofrequency (UG-PRF) in the gastrocnemius to treat and minimize safety issues.This study compared UG-PRF with sham 100 patients pain. Primary outcome measures include subscale Foot Health Status Questionnaire (FHSQ-pain) "first step" as measured on a visual analogue scale (VAS-"first-step" pain). secondary FHSQ-foot function general foot health, health related quality life (assessed using Short...
Metformin is an important antidiabetic drug that has the potential to reduce skeletal muscle atrophy and promote differentiation of cells. However, exact molecular mechanism underlying these functions remains unclear. Previous studies revealed transcription factor zinc finger E-box-binding homeobox 1 (ZEB1), which participates in tumor progression, inhibits atrophy. Therefore, we hypothesized protective effect metformin might be related ZEB1. We investigated positive on IL-1β-induced by...
This study sought to statistically map the neck disability index (NDI) six-dimension health state short form (SF-6D) estimate algorithms for use in economic analyses patients with chronic pain (CNP). The relationships between NDI and SF-6D scores were estimated by using data from a cohort of (n = 272). By ordinary least squares (OLS), generalized linear modeling (GLM), censored absolute deviations (CLAD) Tobit regression, all 10 items instruments univariately tested against values retained...
<title>Abstract</title> Posttranslational modifications (PTMs) of tubulin, termed as the "tubulin code", play important roles in regulating microtubule functions within subcellular compartments for specialized cellular activities. While numerous tubulin PTMs have been identified, a comprehensive understanding complete repertoire is still underway. In this study, we report that α-tubulin lactylation catalyzed by HDAC6 using lactate to increase dynamics neurons. We identified on lysine 40...
Abstract Muscle atrophy is commonly caused by various diseases but still lacks effective treatment in clinical practice. Here, an artificial circular RNA (circRNA) named circmiR‐29b, which designed to be a molecular sponge for miR‐29b containing 12 imperfect bulged binding sites constructed. CircmiR‐29b shows favorable functional effect with respect repression specific and drastic manner. can protect against vitro muscle induced dexamethasone (Dex), angiotensin II (Ang II), tumor necrosis...
Abstract Objectives To compare the long‐term efficacy between pulsed radiofrequency (PRF) combined with passive stretching (PRF‐PS) exercise and PS alone in reducing pain improving quadriceps muscle strength knee function. Methods Sixty‐two participants were randomly assigned a 1:1 allocation to PRF‐PS group or group. Level of pain, strength, function assessed from baseline first, third, sixth months after treatment using VAS, peak torque (PT), Western Ontario McMaster Universities...
This study compares ultrasound-guided pulsed radiofrequency (UG-PRF) with dry needling (UG-DN) for treating painful shoulder periarthritis (PSP). Twenty-four patients PSP were chosen from the Pain Department of Sixth People's Hospital Nantong between August 2022 and December 2023. They divided into 2 groups, UG-PRF (n = 12) UG-DN 12), using a random number table. Both groups received 1 treatment session stretching exercises afterwards. The aims to analyze compare levels pain severity...
Objective To evaluate the efficacy of wet cupping in treatment postherpetic neuralgia (PHN).Methods One hundred PHN patients were randomized into control group (n=53) (conventional therapies such as anticonvulsants,opioids,superlaser and so on) (n--47) (wet cupping,on top conventional therapies.Wet is done first with a triangular needle pricking skin briefly.Later vacuum tank was immediately placed on that,air extraction helped to suction blood out.Wet administered,twice per week,lasting 4...
Abstract Background Plantar fasciitis (PF) is the most common cause of heel pain. Among several conservative treatments, extracorporeal shock wave therapy (ESWT) considered an effective treatment for refractory plantar fasciitis. Studies have shown that trigger points (TrPs) in triceps surae ESWT may play important role pain PF patients. Therefore, purpose this study was to evaluate efficacy waves combined with TrPs patients by using temperature and pressure based on concept pointsand ESWT....
Zygapophysial joint syndrome is one of the causes chronic cervical and low back pain. At present, mainly in clinical X-ray facet injection, medial branch block neurolysis guided by widely utilized to diagnose or treat pain originated from zygapophysial dysfonction. In recent years, ultrasound as a non-radioactive, convenient, real-time technology, was found be able guide interventional diagnosis treatment syndrome. Its research focus on application relevant efficacy, limitations prospects...