A5025681426- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Total Knee Arthroplasty Outcomes
- Lymphoma Diagnosis and Treatment
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- CAR-T cell therapy research
- Shoulder Injury and Treatment
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Venous Thromboembolism Diagnosis and Management
- Surgical site infection prevention
- Shoulder and Clavicle Injuries
- Knee injuries and reconstruction techniques
- Immunotherapy and Immune Responses
- Hip disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Healthcare Policy and Management
- Amyotrophic Lateral Sclerosis Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Antimicrobial Resistance in Staphylococcus
West Virginia University
2024
University of California, San Francisco
2020-2022
Steadman Clinic
2022
Southern District Health Board
2021
Dunedin Public Hospital
2021
New York University Langone Orthopedic Hospital
2015-2020
Orthopaedic Hospital
2018-2020
NYU Langone Health
2015-2019
Clinical Orthopaedics and Related Research
2018
Pacira (United States)
2018
Abstract Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation macrophages around injured sensory neurons in root ganglia (DRG). Here we demonstrate critical contribution DRG macrophages, but not those at site, to both initiation maintenance mechanical hypersensitivity that characterizes neuropathic pain phenotype. In contrast reported sexual dimorphism microglial pain, depletion reduces injury-induced male female mice....
In January 2013, a large, tertiary, urban academic medical center began participation in the Bundled Payments for Care Improvement (BPCI) initiative total joint arthroplasty, program implemented by Centers Medicare & Medicaid Services (CMS) 2011. Severity-Diagnosis Related Groups (MS-DRGs) 469 and 470 were included. We participated BPCI Model 2, which an episode of care includes inpatient all post-acute costs through 90 days following discharge. The goal this is to improve patient quality...
Total joint arthroplasty is a highly successful surgical procedure for patients with painful arthritic joints. The increasing prevalence of the generating significant expenditures in American healthcare system. Healthcare payers, specifically Center Medicare and Medicaid Services, currently target total as an area cost-savings initiatives, resulting increased scrutiny surrounding orthopaedic care, health resource utilization, hospital readmissions. Identifying complications associated hip...
Although pain management after total knee arthroplasty (TKA) affects rehabilitation, length of stay, and functional outcomes, for patients undergoing TKA has yet to be standardized. Femoral nerve blocks (FNBs) are commonly used as an adjunct; however, these can result in transient quadriceps weakness have been associated with in-hospital falls. Periarticular infiltration liposomal bupivacaine recently introduced a long-acting analgesic that administered without affecting motor function.(1)...
Background: Revision shoulder arthroplasty is a technically challenging procedure. It associated with increased blood loss and operative time, it frequently necessitates revision implants, augments, bone-grafting. Shoulder systems convertible-platform humeral stem have been developed to reduce the complexity of procedures by eliminating need for component explantation when converting from anatomic (hemiarthroplasty or total arthroplasty) reverse (rTSA). Methods: A multicenter, retrospective...
To review and report functional outcomes, complications, survivorship associated with total knee arthroplasty (TKA) in the treatment of post-traumatic arthritis (PTA).We conducted a systematic according to PRISMA guidelines. We searched PubMed, Cochrane Library, SCOPUS December 2015 for English-language clinical research studies, both prospective retrospective, examining use TKA PTA. All relevant articles were accessed full. The manual search included references retrieved articles. extracted...
Marked underutilization rates of total joint arthroplasty in minorities compared with nonminorities exist, a paucity literature surrounding inequities related to shoulder (TSA). Using the Statewide Planning and Research Cooperative System database, patients who underwent elective TSA New York State (NYS) were identified characterized by age, race, gender, medical comorbidities, payor status. Patients stratified into 4 separate 5-year periods from 1990 2009. Comorbidity severity was defined...
Background: Medial femoral condyle (MFC) chondral defects cause knee pain. Clinical studies have shown worse functional outcomes and cartilage defect fill rates after microfracture in obese patients (BMI ≥30) for with size ≥2 cm 2 . Purpose: To determine the effect of obesity, size, thickness on force sustained at base full-thickness MFC during weightbearing. Study Design: Controlled laboratory study. Methods: Eight human cadaveric knees were loaded 15° flexion. A sensor measured across...
Aims The aim of this study was to determine the optimal regimen for management pain following total knee arthroplasty (TKA) by comparing outcomes and cost-effectiveness different protocols implemented at a large, urban, academic medical centre. Patients Methods Between September 2013 2015, we used series modifications our standard after TKA. In May 2014, there department-wide transition from focused on femoral nerve blocks (FNB) periarticular injections liposomal bupivacaine. February...
Abstract Background TKA pain management protocols vary widely with no current consensus on a standardized regimen. Multimodal aim to address control, facilitate functional recovery, and maintain patient satisfaction. Questions/purposes (1) Did changes our protocol, specifically adding liposomal bupivacaine, eliminating patient-controlled analgesia (PCA), discontinuing femoral nerve blocks (FNBs), affect narcotic consumption after TKA? (2) these patient-reported scores? (3) Does the use of an...
Infection in the setting of shoulder arthroplasty can result significant pain, loss function, and need for additional surgery. As use increases, medical economic burdens periprosthetic joint infection increase as well. The ideal management infected prostheses has not been established. This report describes 9 patients from a single institution who had an that was definitively managed with cement spacer. All minimum 2 years follow-up. Of this study, 6 were men. Mean age 73±9 years. study...
Nasal-swab screening for methicillin-resistant Staphylococcus aureus (MRSA) has a quicker turnaround time than other bacterial culture methods, with results available within 24 h. Although MRSA nasal-swab is not intended to guide antimicrobial therapy, this method may give clinicians additional information earlier tailoring of empiric agents.To describe the diagnostic characteristics in predicting infections hospitalized patients receiving treatment IV vancomycin.A retrospective...