A5029668897- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Antimicrobial Resistance in Staphylococcus
- Neonatal and Maternal Infections
- Antibiotic Use and Resistance
- Anesthesia and Sedative Agents
- Pneumonia and Respiratory Infections
- Pediatric Pain Management Techniques
- Infant Nutrition and Health
- Nausea and vomiting management
- Hemoglobinopathies and Related Disorders
- Intensive Care Unit Cognitive Disorders
- Iron Metabolism and Disorders
- Colorectal Cancer Treatments and Studies
- Bacterial Identification and Susceptibility Testing
- Anesthesia and Neurotoxicity Research
- Antibiotic Resistance in Bacteria
- Erythropoietin and Anemia Treatment
- Palliative Care and End-of-Life Issues
- Lung Cancer Treatments and Mutations
- Nosocomial Infections in ICU
- Gastric Cancer Management and Outcomes
- Preterm Birth and Chorioamnionitis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Alberta Health Services
2015-2024
Foothills Medical Centre
2019-2024
Alberta Children's Hospital
2014-2023
Alberta Health
2020-2022
University of Calgary
2010-2022
Calgary Laboratory Services
2022
St. Boniface Hospital
2017
Hospital for Sick Children
2017
St. Paul's Hospital
2017
Background: Use of dexmedetomidine in critically ill pediatric patients is increasing despite limited data on effects mechanical ventilation times, use other sedatives, adverse effects, and withdrawal. Objectives: To describe the tolerability a large cohort children. Methods: This was retrospective study receiving intensive care unit. Ethical approval granted by local review board. Data administration, ventilatory support, withdrawal were collected. Results: There 219 included....
Vancomycin is widely used to treat infections caused by methicillin-resistant Staphylococcus aureus. Data for dosing and monitoring of this drug in pediatric patients are lacking, clinicians who treating children often follow guidelines established adults.To examine the total daily doses vancomycin required reach therapeutic trough levels (i.e., 10-20 mg/L) infants, children, adolescents, assess number whom achieved with current empiric (40-60 mg/kg daily).This chart review evaluated 1 month...
Background: Continuous infusions of dexmedetomidine are increasingly used for sedation in critically ill pediatric patients. Emerging data suggest potential benefits when neonates, including reduced sedative requirements and earlier enteral feeds. Objective: To describe the use, adverse effects, signs withdrawal a cohort neonates receiving dexmedetomidine, majority whom were concomitant opioids. Methods: This was retrospective, descriptive review 38 medical surgical neonatal intensive care...
BACKGROUND: Published information evaluating frequency of and risk factors for vancomycin-induced acute kidney injury (AKI) in the pediatric intensive care unit (PICU) population is conflicting. OBJECTIVES: The primary objective was to describe proportion our PICU patients who developed AKI with intravenous (IV) vancomycin. secondary associated potential factors. METHODS: Pediatric (0–18 years) received their first IV vancomycin dose were evaluated this retrospective chart review. defined...
Vancomycin is recommended for optimal treatment of late-onset sepsis caused by coagulase-negative Staphylococcus in neonates.To assess the performance an empirical vancomycin dosing regimen achieving target trough levels, and to revise this if needed.Data regarding doses levels were collected pharmacokinetic parameters calculated, where possible, neonates receiving vancomcyin a neonatal intensive care unit. The primary measure was percentage with initial prevancomycin <10 mg/L, 10 mg/L 20...
Nasal-swab screening for methicillin-resistant Staphylococcus aureus (MRSA) has a quicker turnaround time than other bacterial culture methods, with results available within 24 h. Although MRSA nasal-swab is not intended to guide antimicrobial therapy, this method may give clinicians additional information earlier tailoring of empiric agents.To describe the diagnostic characteristics in predicting infections hospitalized patients receiving treatment IV vancomycin.A retrospective...
<p><strong>ABSTRACT</strong></p><p><strong>Background:</strong> Thiamine (vitamin B1) is an essential cofactor responsible for the breakdown of glucose, and its deficiency associated with Wernicke encephalopathy (WE). There a lack evidence from systematic studies on optimal dosing thiamine WE.</p><p><strong>Objectives:</strong> The primary objective was to describe prescribing patterns IV in adult patients admitted large...
Abstract Aim: To evaluate an extended interval dosing (EID) regimen of gentamicin in neonates ≤28‐week gestation. Methods: In 2008, EID for was introduced all admitted to the NICU Calgary. The based on a 22 h level after first dose 5mg/kg. We conducted observational study 33 infants gestation from day life and compared peak trough levels with historical control 34 who received 2.5 mg/kg every 24 (TID, traditional dosing). Results: group, level, 36 20 48 13 neonates. All neonates, except one,...
Vancomycin is recommended for optimal treatment of late-onset sepsis caused by coagulase-negative Staphylococcus in neonates. To assess the performance an empirical vancomycin dosing regimen achieving target trough levels, and to revise this if needed. Data regarding doses levels were collected pharmacokinetic parameters calculated, where possible, neonates receiving vancomcyin a neonatal intensive care unit. The primary measure was percentage with initial prevancomycin <10 mg/L, 10 mg/L 20...
Medication reconciliation can reduce medication errors and mortality. With limited availability of clinical pharmacists, it is important to determine the resources that will yield most complete information about a patient's history.To identify time-efficient sources history for use by clinicians in pediatric care setting.In July August 2009, newly admitted patients (under 18 years age) were identified, best possible (BPMH) was compiled from admission each chart, provincial prescription...
BACKGROUND: Extended-interval aminoglycoside dosing is increasingly used in neonates; however, guidance on how to monitor concentrations and adjust dosages accordingly limited. OBJECTIVE: To prospectively validate the use of a 22-hour gentamicin concentration table for individualization extended-interval neonatal population by examining peak trough achieved through its use. METHODS: A prospective observational study was carried out using post–first-dose determining intervals neonates....
This retrospective cohort study describes the patterns of antibiotic use for treatment ventilator-associated pneumonia (VAP) in Calgary Zone Alberta Health Services. Timing, appropriateness, and duration antibiotics were evaluated two hundred consecutive cases VAP derived from 4 adult intensive care units (ICU). Antibiotic therapy was initiated less than 24 hours diagnosis 83% cases. Although most patients (89%) received empiric that demonstrated vitro sensitivity to identified pathogens,...
We report 6 cases of intravenous levofloxacin use to treat multidrug-resistant nosocomial respiratory infections in neonates with a postmenstrual age ranging from 27 42 weeks. Because lack neonatal-specific information for levofloxacin, the usual pediatric dosage (10 mg/kg per dose every 12 hours) was used these patients. Clinical cure occurred 5 Only minimal short-term adverse effects were noted.
Objective: To assess the performance of a gentamicin dosing table for individualization extended-interval (EID) in neonatal population >7 days old.Methods: A prospective observational study was carried out on concentrations achieved using neonates old. Neonates were given 5 mg/kg IV gentamicin; then 22 h post-first dose used to individualize intervals. Pre- and post-serum measured calculate true peak trough achieved.Results: Use resulted intervals that provided appropriate (mean 9.8 ± 1.8...
Early-onset sepsis results in increased morbidity and mortality preterm infants. Antimicrobial Stewardship Programs (ASPs) address the need to balance adverse effects of antibiotic exposure with for empiric treatment infants at highest risk early-onset sepsis.All <34 weeks gestational age born during a 6-month period before (January 2017-June 2017) after 2019-June 2019) implementation ASP May 2018 were reviewed. The presence perinatal factors, eligibility for, versus initial antibiotics was...
To describe the practice settings and prescribing practices of oncology pharmacists with additional authorization.A descriptive, cross-sectional survey all in Alberta was conducted using a web-based questionnaire over four weeks between March April 2016. Pharmacists were identified from Cancer Services Pharmacy Directory leadership staff Health Services. Descriptive statistics used to setting, practices, motivators apply for authorization, facilitators barriers prescribing. Logistic...
To evaluate the impact of dexmedetomidine on opioid use in neonates.A retrospective chart review neonates that received compared to matched historical controls a surgical tertiary NICU. The primary endpoint was overall exposure. Secondary endpoints included duration regular use, wean, mechanical ventilation, and time achieve full enteral feeds.There were no statistically significant differences exposure (60.3 vs 42.6 mcg ME/kg, p = .25), (583 340 h, .07), or wean (261 147 .12) between two...
Neonates are susceptible to numerous infections. Factors that predispose these patients nosocomial infections include very low birth weight, small size for gestational age, immunologic immaturity, and exposure invasive procedures, including insertion of intravascular catheters assisted ventilation. Stenotrophomonas maltophilia is an opportunistic, gram-negative aerobic bacillus with a high level intrinsic resistance known cause This organism may many different systems, bloodstream...