A5061500809- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebral Venous Sinus Thrombosis
- Allergic Rhinitis and Sensitization
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Spinal Fractures and Fixation Techniques
- Botulinum Toxin and Related Neurological Disorders
- Ocular Surface and Contact Lens
- Virtual Reality Applications and Impacts
- Cervical and Thoracic Myelopathy
- S100 Proteins and Annexins
- Simulation-Based Education in Healthcare
- Glaucoma and retinal disorders
- Visual and Cognitive Learning Processes
Touro College
2021-2024
University of California, San Francisco
2019-2022
Abstract Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation macrophages around injured sensory neurons in root ganglia (DRG). Here we demonstrate critical contribution DRG macrophages, but not those at site, to both initiation maintenance mechanical hypersensitivity that characterizes neuropathic pain phenotype. In contrast reported sexual dimorphism microglial pain, depletion reduces injury-induced male female mice....
Microgliosis is a hallmark of many neurological diseases, including Alzheimer's disease, stroke, seizure, traumatic brain and spinal cord injuries, peripheral optic nerve injuries. Recent studies have shown that the newly self-renewed microglia specific functions. However, mechanism adult proliferation remains largely unclear. Here, with single-cell RNA sequencing, flow cytometry, immunohistochemistry, we demonstrate sciatic injury induced two distinct phases in mouse cord, each different...
Purpose: To compare clinical outcomes and patient preference for the dexamethasone intracanalicular insert (DEX) versus topical loteprednol (LOT) or olopatadine (OLO) treatment of allergic conjunctivitis in a real-world model allergen exposure. Methods: This was prospective comparative trial. Adults with testing-confirmed bilateral received DEX more symptomatic eye either LOT 2 times daily OLO once 30 days fellow eye. The primary outcome treatment. Clinical included ocular itching hyperemia,...
Little is known about the therapeutic relationship between coblation discoplasty and cervicogenic dizziness (CGD). CGD can be caused by abnormal proprioceptive inputs from compressed nerve roots, intradiscal mechanoreceptors nociceptors to vestibulospinal nucleus in degenerative cervical disc. The aim was analyze efficacy of through ablation disc decompression a 12-month follow-up retrospective study.From 2015 2019, 42 patients who received discolplasty were recruited as surgery group, 22...
There are growing interests to study the molecular and cellular interactions among immune cells sensory neurons in dorsal root ganglia after peripheral nerve injury. Peripheral monocytic cells, including macrophages, known respond a tissue injury through phagocytosis, antigen presentation, cytokine release. Emerging evidence has implicated contribution of macrophages neuropathic pain development axonal repair context Rapidly phenotyping (or "rapid isolation of") response is desired identify...
There are growing interests to study the molecular and cellular interactions among immune cells sensory neurons in dorsal root ganglia after peripheral nerve injury. Peripheral monocytic cells, including macrophages, known respond a tissue injury through phagocytosis, antigen presentation, cytokine release. Emerging evidence has implicated contribution of macrophages neuropathic pain development axonal repair context Rapidly phenotyping (or "rapid isolation of") response is desired identify...