A5075914665- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Synthesis and Catalytic Reactions
- Endoplasmic Reticulum Stress and Disease
- Protein Kinase Regulation and GTPase Signaling
- Cancer-related Molecular Pathways
- Enzyme Structure and Function
- Nuclear Structure and Function
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
Jinan University
2017-2024
Key Laboratory of Guangdong Province
2017-2024
Guangzhou Medical University
2016
The SPRY domain-containing SOCS box proteins SPSB1, SPSB2, and SPSB4 utilize their SPRY/B30.2 domain to interact with a short region in the N-terminus of inducible nitric oxide synthase (iNOS), recruit an E3 ubiquitin ligase complex polyubiquitinate iNOS, resulting proteasomal degradation iNOS. Inhibitors that can disrupt endogenous SPSB-iNOS interactions could be used augment cellular NO production, may have antimicrobial anticancer activities. We previously reported rational design cyclic...
The SPRY domain-containing SOCS box protein 2 (SPSB2) is one of four mammalian SPSB proteins that are characterized by a C-terminal and central SPRY/B30.2 domain. SPSB2 interacts with inducible nitric oxide synthase (iNOS) via the domain polyubiquitinates iNOS, resulting in its proteasomal degradation. Inhibitors can disrupt SPSB2–iNOS interaction augment NO production may serve as novel anti-infective anticancer agents. previously determined murine structure not reflect true apo...