A5004500126- Heavy Metal Exposure and Toxicity
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Ginseng Biological Effects and Applications
- Mercury impact and mitigation studies
- Multisensory perception and integration
- Trace Elements in Health
- Tactile and Sensory Interactions
- Heavy metals in environment
- Air Quality and Health Impacts
- Obesity, Physical Activity, Diet
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Interference and Gene Delivery
- Body Composition Measurement Techniques
- Healthcare professionals’ stress and burnout
- Cancer Mechanisms and Therapy
- Neurosurgical Procedures and Complications
- Melanoma and MAPK Pathways
- Child Nutrition and Water Access
- Autophagy in Disease and Therapy
- Aluminum toxicity and tolerance in plants and animals
- ATP Synthase and ATPases Research
- Telomeres, Telomerase, and Senescence
- Stress Responses and Cortisol
- Genomics, phytochemicals, and oxidative stress
Soochow University
2015-2025
Children's Hospital of Suzhou University
2023-2024
Soochow University
2022
XinHua Hospital
2012-2019
Shanghai Jiao Tong University
2012-2019
Hainan General Hospital
2016
Chongqing Medical University
2012-2015
Huainan Mining Industry Group (China)
2009
Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferroptosis and molecular events causing GPX4 reduction during ischemia-reperfusion (I/R) remain largely unknown. Using transcriptomics, we identify that situated at interface inner cortex outer medulla, a hyperactive site post-I/R injury. We further discover OTU deubiquitinase 5 (OTUD5) as...
Despite the global abundance of studies on children's lead (Pb) exposure, magnitude Pb exposure among children across China remains unclear, especially for rural areas. In 2000, was removed from petrol, marking a change in sources China. To better understand and inform potential approaches to reduction, we conducted national blood survey 31,373 (0–84 months old) May 2013 March 2015, using multi-stage multi-strata sampling method. Blood levels (BLLs) were tested graphite furnace atomic...
Our study aimed to explore the anxiety levels and possible associated factors in pediatric medical staff Jiangsu province during an outbreak of Coronavirus Disease 2019 (COVID-19).
Gallbladder cancer has poor prognosis and limited therapeutic options. Arctigenin, a representative dibenzylbutyrolactone lignan, occurs in variety of plants. However, the molecular mechanisms involved antitumor effect arctigenin on gallbladder have not been fully elucidated. The expression levels epidermal growth factor receptor were examined 100 matched pairs tissues. A positive correlation between high was observed Pharmacological inhibition or via RNA interference induced cellular...
This technical note introduces the application of a 3D-printed personalized cranial defect flap support device for treatment severe ipsilateral subgaleal effusion (SISE) after decompressive craniectomy (DC). By closely fitting this to defect, significant improvements were observed, including resolution effusion, restoration midline structures, and facilitation neurological recovery. report provides detailed description design manufacturing process highlights its therapeutic effects through...
Objective . To determine the blood lead levels and identify related risk factors among preschool children in a polluted area (Taizhou, China) provide theoretical support for prevention of pollution. Methods A stratified-clustered-random sampling method was used to survey sample. Blood were determined by tungsten atomizer absorption spectrophotometer. Results total 2,018 subjects (average age 59 months; 1,087 boys 931 girls) included. The arithmetic mean, geometric median 56.4 μ g/L, 48.9 46...
Leukemia stem cells (LSCs) play important roles in leukemia initiation, progression and relapse, thus represent a critical target for therapeutic intervention. Hence, it is extremely urgent to explore new strategies directly targeting LSCs acute myelogenous (AML) therapy. We show here that Angelica sinensis polysaccharide (ASP), major active component Dong quai (Chinese sinensis), effectively inhibited human AML <TEX>$CD34^+CD38^-$</TEX> cell proliferation vitro culture dose-dependent manner...
Glioblastoma is one of the most aggressive primary brain tumors with few treatment strategies. β-Elemene a sesquiterpene known to have broad spectrum antitumor activity against various cancers. However, signaling pathways involved in β-elemene induced apoptosis glioblastoma cells remains poorly understood. In this study, we reported that exhibited antiproliferative on U87 and SHG-44 cells, cell death through induction apoptosis. Incubation these led activation caspase-3 generation reactive...
The hematopoietic system is one of the potential targets lead intoxication. Recognition lead-related deleterious outcomes promotes us to explore therapeutic intervention. Here, we show that ginsenoside Rg1 (Rg1), extracted from Chinese herb Panax ginseng, remarkably ameliorates acetate-caused hematological index distortion as well advanced stem cells (HSCs) aging and associated inflammation response. Specifically, administration alleviated increment p53-p21-Rb signaling in aged HSCs induced...
In adults, bone hematopoietic cells are responsible for the lifelong production of all blood cells. It is affected in aging, with progressive loss physiological integrity leading to impaired function by cellular intrinsic and extrinsic factors. However, intervention measures, which directly inhibit aging cells, remain be investigated. present study, 10 µmol/l ginsenoside Rg1 (Rg1) markedly alleviated phenotypes Sca‑1+ following vitro exposure. addition, protective effects on was confirmed...
Abstract The mitochondrial integrity and function in endothelial cells are essential for angiogenesis. TIMM44 (translocase of inner membrane 44) is mitochondria. Here we explored the potential possible mechanisms In HUVECs, human retinal microvascular hCMEC/D3 brain cells, silence by targeted shRNA largely inhibited cell proliferation, migration vitro capillary tube formation. silencing disrupted functions causing protein input arrest, ATP reduction, ROS production, depolarization, leading...
Traditional chemotherapy strategies for human leukemia commonly use drugs based on cytotoxicity to eradicate cancer cells. One predicament is that substantial damage normal tissues likely occur in the course of standard treatments. Obviously, it urgent explore therapies can effectively eliminate malignant cells without affecting Our previous studies indicated ginsenoside Rg1 (Rg1), a major active pharmacological ingredient ginseng, could delay hematopoietic stem cell senescence. However,...