A5027369393- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Estrogen and related hormone effects
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Bipolar Disorder and Treatment
- Breast Cancer Treatment Studies
- Algal biology and biofuel production
- Cancer Treatment and Pharmacology
- Adolescent and Pediatric Healthcare
- Dermatological and COVID-19 studies
- Amoebic Infections and Treatments
- ATP Synthase and ATPases Research
- Histone Deacetylase Inhibitors Research
- Melanoma and MAPK Pathways
- Body Contouring and Surgery
- Vascular Tumors and Angiosarcomas
- Bone and Joint Diseases
Cixian People's Hospital
2024
Zhujiang Hospital
2012-2024
Southern Medical University
2012-2024
Zhejiang University of Technology
2024
Wenzhou Medical University
2024
Tianjin Medical University General Hospital
2023
Tianjin Medical University
2023
Weatherford College
2020
Ningbo University
2017
Nanfang Hospital
2014
Microbes, including bacteria, viruses, fungi, and other eukaryotic organisms, are commonly present in multiple organs of the human body contribute significantly to both physiological pathological processes. Nowadays, development sequencing technology has revealed presence composition intratumoral microbiota, which includes Fusobacterium, Bifidobacteria, Bacteroides, shed light on significant involvement progression colorectal cancer (CRC). Here, we summarized current understanding microbiota...
BACKGROUND Cancer-associated fibroblasts (CAFs) are key factors in malignant tumor initiation, progression, and metastasis. However, the effect of CAFs autophagy on triple-negative breast cancer (TNBC) cells is not clear. In this study, growth TNBC regulated by was evaluated. MATERIAL AND METHODS were obtained from invasive tumors identified Western blot immunofluorescence staining assay. co-cultured with cells, migration invasion evaluated Matrigel-coated Transwell inserts. detected MTT...
Accumulating evidence has demonstrated that long non‑coding RNAs (lncRNAs) play important roles in the pathogenesis and development of diverse types human disorders. Cancer susceptibility candidate 9 (CASC9), a gene encoding lncRNA, frequently been reported to be dysregulated implicated multiple malignancies. However, biological role lncRNA CASC9 breast cancer (BC) remains largely unknown. The present study aimed investigate BC elucidate potential molecular mechanisms involved. In study, was...
Tumor mutation burden (TMB) was a promising marker for immunotherapy. We aimed to investigate the prognostic role of TMB and its relationship with immune cells infiltration in gastric cancer (GC). analyzed landscape all GC cases each patient calculated patients were divided into TMB-high TMB-low group. Differentially expressed genes (DEGs) between two groups identified pathway analysis performed. The evaluated Kaplan-Meier performed infiltration. At last, hub risk score (TMBPRS) constructed...
Critical limb ischemia (CLI) remains a significant clinical challenge with high morbidity and mortality. Considering the critical role of hypoxia-inducible factor 1α (HIF-1α) in hypoxic site to induce angiogenesis by regulating expression growth factors, we prepared cooperative composite (P-F-HKUST-1) mixing thermo-responsive hydrogel (PPCN) folic acid modified copper-based MOFs (F-HKUST-1) for hindlimb therapy. The gelation P-F-HKUST-1 muscle generated more serious environment subsequently...
Background SARS-CoV-2 could trigger multiple immune responses, leading to several autoimmune diseases, including thyroid diseases. Many cases of diseases caused by COVID-19 infection have been reported. Here, we describe the disease development patients with after infection. Methods The clinical characteristics, diagnosis and treatment five different were Results Female primary which stable for many years One month infection, has undergone evolution. Case 1, a patient history long-term...
Based on its pathological characteristics, breast cancer is a highly heterogeneous disease. Triple negative (TNBC) an aggressive subtype, and due to lack of effective therapeutic targets, patients with TNBC do not significantly benefit from endocrine or anti‑HER2 therapy. Conventional chemotherapy has been regarded as the only systemic therapy option for TNBC, but efficacy remains limited. Estrogen receptor β (ERβ) identified tumor suppressor in TNBC. Therefore, aim present study was...
This study aims to investigate the correlations between rapidly accelerated fibrosarcoma/mitogen-activated protein kinase (MEK)/extracellular signal-regulated signaling pathway and clinicopathological features prognosis for patients with breast cancer having axillary lymph node metastasis.A total of 118 tissues metastasis (axillary group), 150 non-axillary (non-axillary 216 normal (normal group) were enrolled in this study. The messenger RNA expressions fibrosarcoma, MEK, extracellular...
Abstract Breast cancer is one of the most common malignancies in women worldwide. Many studies have shown that tumor microenvironment cells, immune and stromal cell infiltration an important impact on prognosis, so it to identify biomarkers for achieving better treatment prognosis. To understand relationship between cell-related genes we screened patients with breast The Cancer Genome Atlas (TCGA) database divided them into high low groups based immune/stromal scores. We next identified...
This study aimed to identify prognostic long noncoding RNAs (lncRNAs) signature for predicting the prognosis of patients with rectal cancer. LncRNA-sequencing data and clinicopathological cancer were retrieved from The Cancer Genome Atlas database. Univariate multivariate Cox proportional hazards regression analysis, least absolute shrinkage, selection operator analysis Kaplan-Meier curve method employed lncRNAs construct multi-lncRNA signature. Finally, five (AC079789.1, AC106900.2,...
Background: Adenosine triphosphatase H+ transporting accessory protein 2 (ATP6AP2), also known as (pro)renin receptor, is implicated in tumorigenesis and the progression of several types cancer. This study investigated role ATP6AP2 breast Methods: UALCAN ONCOMINE datasets were utilized to compare transcript levels cancer normal tissues. GOBO applied examine expression different cell lines. We used cBioPortal website explore gene alterations copy number Cell Counting Kit-8 transwell assays...
Background: The recent discovery of microRNAs (miRNAs) and their extracellular presence suggest a potential role these regulatory molecules in defining the metastatic cancer cells mediating cancer–host communication. This study aims to improve sensitivity miRNA detection via DNAzyme-based method enhance selectivity by using probe reduce nonspecific amplification. Methods: probes were chemically synthesized with phosphate at 5 ' end purified polyacrylamide gel electrophoresis. Exosomal RNA...
This study aimed to explore the impact of ABL1-tyrosine kinase inhibitors (TKIs) adherence on survival chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) children and clarify potential predictors patients' prognosis from TKIs intake practices.Ninety newly diagnosed Ph+ ALL patients who received were enrolled. We collected baseline characteristics adverse events in all children; moreover, was measured by an eight-item Morisky medication scale (MMAS-8). Progression-free (PFS) overall...
Objective To investigate the effect of DNA polymerase θ (POLQ) expression in breast cancer cell line MCF-7 on radiation sensitivity.Methods Real-time quantitative-polymerase chain reaction (qRT-PCR) and Western blotting were used to evaluate POLQ mRNA protein after cells transfected.Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay,colony-forming test,and flow cytometry changes.Results The mean level POLQ-siRNA group was (0.12 ±0.01 ) times blank control ( P＜0.01 ),and rate (32.01 ±...
Objective To clarify the effect of cancer-associated fibroblasts (CAFs ) autophagy on metastasis triple-negative breast cancer (TNBC) cells co-cultured with CAFs. Methods (1) Purification and identification CAFs. CAFs normal (NFs) were prospectively obtained from tissue six patients TNBC at stage Ⅱ or Ⅲ, who treated in Zhujiang Hospital Southern Medical University January 2015 to December 2016.α-smooth muscle actin (α-SMA) was labeled by fluorescent antibody proportion α-SMA positive...