A5056788425- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Galaxies: Formation, Evolution, Phenomena
- Astronomy and Astrophysical Research
- Stellar, planetary, and galactic studies
- Obstructive Sleep Apnea Research
- Astrophysics and Star Formation Studies
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Astrophysical Phenomena and Observations
- Heart Rate Variability and Autonomic Control
- Sleep and Wakefulness Research
- Eicosanoids and Hypertension Pharmacology
- Sulfur Compounds in Biology
- Cardiovascular and Diving-Related Complications
- Hemoglobin structure and function
- Respiratory Support and Mechanisms
- Nitric Oxide and Endothelin Effects
- Neural dynamics and brain function
- Gamma-ray bursts and supernovae
- Plant Water Relations and Carbon Dynamics
- Neonatal Respiratory Health Research
- Enzyme Structure and Function
- Spectroscopy and Laser Applications
- Adipose Tissue and Metabolism
University of Chicago
2016-2025
Chinese Academy of Sciences
2008-2024
Xi'an Jiaotong University
2023-2024
State Key Laboratory of Electrical Insulation and Power Equipment
2023-2024
Peking University
2016-2024
Center for Systems Biology
2015-2024
Kavli Institute for Theoretical Sciences
2016-2024
Institute of Biophysics
2021-2024
Torrey Pines Institute For Molecular Studies
2024
Scripps (United States)
2024
Heterozygous mutations in the gene encoding isocitrate dehydrogenase-1 ( IDH1 ) occur certain human brain tumors, but their mechanistic role tumor development is unknown. We have shown that tumor-derived impair enzyme's affinity for its substrate and dominantly inhibit wild-type activity through formation of catalytically inactive heterodimers. Forced expression mutant cultured cells reduces enzyme product, α-ketoglutarate (α-KG), increases levels hypoxia-inducible factor subunit HIF-1α, a...
Reflexes from the carotid body have been implicated in cardiorespiratory disorders associated with chronic intermittent hypoxia (CIH). To investigate whether CIH causes functional and/or structural plasticity body, rats were subjected to 10 days of recurrent or normoxia. Acute exposures episodes evoked long-term facilitation (LTF) sensory activity CIH-conditioned but not control animals. The magnitude LTF depended on length conditioning and was completely reversible unique CIH, because a...
We present new improved constraints on the Hubble parameter H ( z ) in redshift range 0.15 < 1.1, obtained from differential spectroscopic evolution of early-type galaxies as a function redshift. extract large sample ∼ 11000) several surveys, spanning almost 8 billion years cosmic lookback time (0.15 1.42). select most massive, red elliptical galaxies, passively evolving and without signature ongoing star formation. Those can be used standard chronometers, firstly proposed by Jimenez...
Chronic intermittent hypoxia (CIH) occurs in patients with sleep apnoea and has adverse effects on multiple physiological functions. Previous studies have shown that reflexes arising from carotid bodies mediate CIH-evoked cardio-respiratory responses, reactive oxygen species (ROS) play important roles eliciting systemic responses to CIH. Very little is known about the molecular mechanisms underlying The transcriptional activator hypoxia-inducible factor-1 (HIF-1) mediates a broad range of...
Gaseous messengers, nitric oxide and carbon monoxide, have been implicated in O 2 sensing by the carotid body, a sensory organ that monitors arterial blood levels stimulates breathing response to hypoxia. We now show hydrogen sulfide (H S) is physiologic gasotransmitter of enhancing its Glomus cells, site express cystathionine γ-lyase (CSE), an H S-generating enzyme, with hypoxia increasing S generation stimulus-dependent manner. Mice genetic deletion CSE display severely impaired body...
Abstract The Cosmic Evolution Survey (COSMOS) has become a cornerstone of extragalactic astronomy. Since the last public catalog in 2015, wealth new imaging and spectroscopic data have been collected COSMOS field. This paper describes collection, processing, analysis these to produce reference photometric redshift catalog. Source detection multiwavelength photometry are performed for 1.7 million sources across 2 deg field, ∼966,000 which measured with all available broadband using both...
Context. How galaxies form, assemble, and cease their star formation is a central question within the modern landscape of galaxy evolution studies. These processes are indelibly imprinted on stellar mass function (SMF), its measurement understanding key to uncovering unified theory evolution. Aims. We present constraints shape SMF, quiescent fraction, cosmic density across 90% history Universe from z = 7.5 → 0.2 as means study physical that underpin Methods. The COSMOS survey an ideal...
To investigate whether the transcriptional activator hypoxia-inducible factor 1 (HIF-1) is required for ventilatory responses to hypoxia, we analyzed mice that were either wild type or heterozygous a loss-of-function (knockout) allele at Hif1a locus, which encodes O 2 -regulated HIF-1α subunit. Although response acute hypoxia was not impaired in +/− mice, primarily mediated via vagal afferents, whereas wild-type carotid body chemoreceptors played predominant role. When bodies isolated from...
Reflexes arising from the carotid bodies may play an important role in cardiorespiratory changes evoked by chronic intermittent hypoxia (CIH). In present study, we examined whether CIH affects hypoxic sensing ability of and, if so, what mechanisms. Experiments were performed on adult male rats (Sprague-Dawley, 250-300 g) exposed to two paradigms for 10 days: 1) multiple exposures short durations per day (SDIH; 15 s 5% O(2) + 5 min 21% O(2), 9 episodes/h, 8 h/day) and 2) single exposure...
Chronic intermittent hypoxia (CIH) augments physiological responses to low partial pressures of O2 in the arterial blood. Adrenal medullae from adult rats, however, are insensitive direct effects acute hypoxia. In present study, we examined whether CIH induces hypoxic sensitivity rat adrenal medulla and, if so, by what mechanism(s). Experiments were performed on male rats exposed (15 s 5% followed 5 min 21% O2; 9 episodes h(-1); 8 h d(-1); for 3 or 10 days) comparable, cumulative durations...
Respiratory motoneuron response to hypoxia is reflex in nature and carotid body sensory receptor constitutes the afferent limb of this reflex. Recent studies showed that repetitive exposures evokes long term facilitation nerve discharge (sLTF) rodents exposed chronic intermittent (CIH). Although with anti-oxidants suggested involvement reactive oxygen species (ROS)-mediated signaling eliciting sLTF, source mechanisms associated ROS generation have not yet been investigated. We tested...
Intermittent hypoxia (IH) occurs in many pathological conditions including recurrent apneas. Hypoxia-inducible factors (HIFs) 1 and 2 mediate transcriptional responses to low O(2). A previous study showed that HIF-1 mediates some of the IH-evoked physiological responses. Because HIF-2alpha is an orthologue HIF-1alpha, we examined effects IH on HIF-2alpha, O(2)-regulated subunit expression, pheochromocytoma 12 cell cultures. In contrast up-regulation was down-regulated by IH. Similar...
Close encounters between galaxies are expected to be a viable mechanism, as predicted by numerical simulations, which accretion onto supermassive black holes can initiated. To test this scenario, we construct sample of 562 (M* > 2.5 × 1010 M☉) in kinematic pairs over the redshift range 0.25 < z 1.05 that more likely interacting than well-matched control 2726 not identified being pair, both from zCOSMOS 20k spectroscopic catalog. Galaxies harbor an active galactic nucleus (AGN) on basis their...
Recurrent apnea with intermittent hypoxia is a major clinical problem in preterm infants. Recent studies, although limited, showed that adults who were born exhibit increased incidence of sleep-disordered breathing and hypertension, suggesting prematurity predisposes to autonomic dysfunction adulthood. Here, we demonstrate adult rats exposed as neonates exaggerated responses by the carotid body adrenal chromaffin cells, which regulate cardio-respiratory function, resulting irregular apneas...
ABSTRACT Star-forming galaxies can in principle be transformed into passive systems by a multitude of processes that quench star formation, such as the halting gas accretion (starvation) or rapid removal AGN-driven outflows. However, it remains unclear which are most significant, primary drivers SF-passive bimodality. We address this key issue galaxy evolution studying chemical properties 80 000 local Sloan Digital Sky Survey Data Release 7. In order to distinguish between different...
Complex interplay between three gases—oxygen, carbon monoxide, and hydrogen sulfide—is necessary to control breathing.
ABSTRACT In this paper, we investigate how massive central galaxies cease their star formation by comparing theoretical predictions from cosmological simulations: EAGLE, Illustris, and IllustrisTNG with observations of the local Universe Sloan Digital Sky Survey (SDSS). Our machine learning (ML) classification reveals supermassive black hole mass (MBH) as most predictive parameter in determining whether a galaxy is forming or quenched at redshift z = 0 all three simulations. This predicted...
We investigate the presence of ionised gas outflows in a sample 141 main-sequence star-forming galaxies at $1.2<z<2.6$ from KLEVER (KMOS Lensed Emission Lines and VElocity Review) survey. Our covers an exceptionally wide range stellar masses, $8.1<\log(M_\star/M_{\odot})<11.3$, pushing outflow studies into dwarf regime thanks to gravitationally lensed objects. stack optical rest-frame emission lines (H$\beta$, [OIII], H$\alpha$ [NII]) different mass bins seek for tracers by using novel,...
Long-term facilitation (LTF) of breathing elicited by episodic hypoxia (EH) is an extensively studied example plasticity respiratory motor behavior. Previous studies employed the paradigm EH wherein each episode was 5 min. This rarely encountered in nature. Brief episodes are frequently with recurrent apneas, hypoxic last a few seconds only. Recent suggest that chronic intermittent (CIH) represents form oxidative stress involving reactive O 2 species. The objectives present study were to...
Previous studies suggest that carotid body responses to long-term changes in environmental oxygen differ between neonates and adults. In the present study we tested hypothesis effects of chronic intermittent hypoxia (CIH) on adult rats. Experiments were performed neonatal (1-10 days) (6-8 wk) males exposed either CIH (9 episodes/h; 8 h/day) or normoxia. Sensory activity was recorded from ex vivo bodies. augmented hypoxic sensory response (HSR) both groups. The magnitude CIH-evoked...