A5080462027- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Frailty in Older Adults
- Asthma and respiratory diseases
- Click Chemistry and Applications
- Gene expression and cancer classification
- Lung Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Hormonal Regulation and Hypertension
- Single-cell and spatial transcriptomics
- Childhood Cancer Survivors' Quality of Life
- Peptidase Inhibition and Analysis
- Exercise and Physiological Responses
Positive Action
2023
Positive Impact
2023
Harvard University
2002-2008
Joslin Diabetes Center
2002-2008
Brigham and Women's Hospital
2002-2008
UNC Lineberger Comprehensive Cancer Center
2005
Humans expressing a defective form of the transcription factor AIRE (autoimmune regulator) develop multiorgan autoimmune disease. We used aire- deficient mice to test hypothesis that this regulates autoimmunity by promoting ectopic expression peripheral tissue- restricted antigens in medullary epithelial cells thymus. This proved correct. The mutant animals exhibited defined profile diseases depended on absence aire stromal Aire-deficient thymic showed specific reduction genes encoding...
Autoimmune regulator (aire) is a transcription factor that controls the self-reactivity of T cell repertoire. Although previous results indicate it exerts this function in part by promoting ectopic expression battery peripheral-tissue antigens epithelial cells thymic medulla, recent data argue for additional roles negative selection thymocytes medullary cells. As one approach to exploring such roles, we performed computational analyses microarray on RNA transcripts from aire-deficient versus...
The lymphotoxin pathway is critical for the development and maintenance of peripheral lymphoid organs. Mice with deficiencies in members this lack lymph nodes Peyer's patches have abnormal spleen architecture. These animals also develop autoantibodies to lymphocytic infiltrates multiple organs, provoking speculation that may play a role central tolerance induction. Indeed, series reports has claimed signals control expression Aire, transcriptional regulator expressed medullary epithelial...
Given the importance of NOD mouse as a model type 1 diabetes, there is surprising lack published information on overall composition thymic and peripheral T-cell compartments. In this study, we revisited some earlier reports abnormalities in strain examined number additional parameters to provide global view T-cells prediabetic mice. cases, concur with past conclusions, but other important areas, find that mice closely resemble nonautoimmune strains. Specifically, contrary reports, thymocyte...
There's always a catch. The post-translational modification of proteins with ubiquitin (Ub) or ubiquitin-like (Ubl) modifiers is an important signal in the regulation variety biological processes, such as degradation and gene expression. Here we report synthesis panel peptide vinyl sulfones (see scheme) harboring various portions Ub C terminus by using safety-catch linker. Depending on their length, compounds can efficiently target Ubl-specific proteases.
The Aire transcription factor plays an important role in immunological self-tolerance by mediating the ectopic expression of peripheral self-antigens thymic medullary epithelial cells (MECs), and deletion thymocytes that recognize them. In Aire-deficient humans or mice, central tolerance is incomplete multiorgan autoimmune disease results. We examined variability Aire's effects on among individual mice three different inbred strains. function was, overall, quite similar backgrounds, although...