A5101862331- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Protein Kinase Regulation and GTPase Signaling
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Protease and Inhibitor Mechanisms
- Traditional Chinese Medicine Studies
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Indoor and Outdoor Localization Technologies
- Healthcare and Venom Research
- Evolution and Genetic Dynamics
- Genomic variations and chromosomal abnormalities
- Cardiovascular Issues in Pregnancy
- Ocular Surface and Contact Lens
- Microbial infections and disease research
- Calpain Protease Function and Regulation
- Lipid metabolism and disorders
- Curcumin's Biomedical Applications
- Yersinia bacterium, plague, ectoparasites research
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Ectopic Pregnancy Diagnosis and Management
- Retinal and Macular Surgery
University of Electronic Science and Technology of China
2014-2024
Quzhou University
2024
Mianyang Central Hospital
2023
Guiyang Medical University
2021
Chongqing Medical University
2021
Beijing University of Chinese Medicine
2017
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2015-2016
Xinjiang Production and Construction Corps
2015
Shanghai Xuhui Central Hospital
2013
Zhejiang University
2009-2010
Indoor localization utilizing received signal strength (RSS) fingerprint has garnered significant attention over the past decade because it is readily captured from MAC layer of ubiquitous hardware devices. However, accuracy RSS fingerprint-based methods notably influenced by two primary factors: 1) disparities between offline and online data distributions induced dynamic environmental changes device heterogeneity 2) inconsistencies among hetero-measure samples (different collected at same...
Background: Genetic factors have been studied extensively for their role in the pathogenesis of primary open angle glaucoma (POAG). This study was conducted to investigate whether manganese superoxide dismutase (SOD2) variants play a significant POAG Chinese population.Methods: included 416 unrelated patients and 997 control subjects. Four SOD2 tag single nucleotide polymorphisms (SNPs), including rs6917589 rs2842980, rs5746136 rs4880, were genotyped by dye terminator-based SNaPshot method....
The CYP1B1 gene has been shown to be related primary open-angle glaucoma (POAG). This study aimed identify the mutation profile of in Chinese individuals with POAG.The included 416 unrelated cases diagnosed as POAG by standard ophthalmological examinations, and 657 healthy controls a population. Genomic DNA was collected from peripheral blood all participants. coding sequence amplified PCR genomic DNA, followed direct sequencing.Among patients POAG, 13 missense mutations, including nine...
Abstract Background Genotyping technologies enable us to genotype multiple Single Nucleotide Polymorphisms (SNPs) within selected genes/regions, providing data for haplotype association analysis. While haplotype-based analysis is powerful detecting untyped causal alleles in linkage-disequilibrium (LD) with neighboring SNPs/haplotypes, the inclusion of extraneous SNPs could reduce its power by increasing number haplotypes each additional SNP. Methods Here, we propose a stepwise procedure...
Glaucoma is a leading cause of irreversible blindness worldwide, and previous studies have shown that, in addition to affecting the eyes, it also causes abnormalities brain. However, not yet clear how primary visual cortex (V1) altered glaucoma. This study used DBA/2J mice as model for spontaneous secondary The aim was compare electrophysiological histomorphological characteristics neurons V1 between 9-month-old age-matched C57BL/6J mice. We conducted single-unit recordings...
Retinitis pigmentosa (RP) is the most important hereditary retinal disease caused by progressive degeneration of photoreceptor cells. This study to identify gene mutations responsible for autosomal recessive retinitis (arRP) in a Chinese family using next-generation sequencing technology. A with 7 members including two individuals affected severe early-onset RP was studied. All patients underwent complete ophthalmic examination. Exome performed on single patient (the proband this family) and...
Congenital cataract is the most common cause of visual disability and blindness in childhood. This study aimed to identify gene mutations responsible for autosomal dominant congenital (ADCC) a Chinese family using next-generation sequencing technology. included eight unaffected five affected individuals. After complete ophthalmic examinations, blood samples proband two available members were collected. Then whole exome was performed on Sanger applied validate causal mutation control samples....
Retinitis pigmentosa (RP) is a leading cause of inherited blindness characterized by progressive degeneration the retinal photoreceptor cells. This study aims to identify genetic mutations in Chinese family RP-2236, an Indian RP-IC-90 and 100 sporadic individuals with autosomal recessive RP (arRP). Whole exome sequencing was performed on index patients all patients. Direct Sanger used validate identified. Four novel one reported mutation crumbs homolog 1 (CRB1) gene, which has been known...
Abstract High prevalence and severity of rheumatoid arthritis (RA) with an early age onset have previously been described in Alaska Native American Indian (AN/AI) populations. The contribution HLA‐DRB1 alleles encoding a similar amino acid sequence, referred to as the shared epitope (SE), RA risk is well recognized multiple populations worldwide. DRB1*1402 allele major SE‐encoding AN/AI However, highly prevalent healthy Natives Southeast (AN), no significant difference from patients,...
Kimmel, R. R., Agnani, S., Yang, Y., Jordan, and Schwartz, J. L. DNA Copy-Number Instability in Low-Dose Gamma-Irradiated TK6 Lymphoblastoid Clones. Radiat. Res. 169, 259–269 (2008).Genomic instability that might occur early during low-dose, fractionated radiation exposures may be traceable radiogenic compared to spontaneous cancers. Using a human 18K cDNA microarray-based comparative genome hybridization protocol, we measured changes copy number at over 14,000 loci nine low-dose 137Cs...
Objectives . Differences among healthy subjects and associated disease risks are of substantial interest in clinical medicine. According to the theory “constitution‐disease correlation” traditional Chinese medicine, we try find out if there is any connection between intolerance cold Yang deficiency constitution molecular evidence gene expression basis specific disorders. Methods Peripheral blood mononuclear cells were collected from Han individuals with ( n = 20) balanced 8) (aged 18–28)...
Routine nerve conduction study (NCS) parameters are less sensitive in the early stage of carpal tunnel syndrome (CTS). Recently, some studies have shown that prolonged distal sensory action potential (DSNAP) duration may be a more technique for diagnosis demyelinating peripheral neuropathies. We aimed to evaluate sensitivity median DSNAP patients with CTS.DSNAP and routine NCS data were retrospectively collected 173 CTS patients, 73 controls, 78 cervical radiculopathy patients.Prolonged...
Objective: To establish the animal model of subchronic manganism, and to explore effect manganese on neurofunction rats protective curcumin neurotoxicity manganism rats. Methods: From July December 2019, 80 SPF male SD were divided into 8 groups according body weight by random number table method, which blank control group, low, middle high dose exposure antagonistic group with 10 in each group. The given intraperitoneal injection 5 mg/kg, mg/kg 15 MnCl(2)·4H(2)O respectively. 100 200 400...
Objective To study the effect of rigid gas permeable contact lens (RGP) on irregular astigmatism caused by corneal laceration. Methods twenty eyes 20 patients with laceration were collected. The fram glasses and RGP fitting performed, corrected visual acuity was recorded. follow-up time 3 months. Results Compared wearing frame glasses, all had an average increase (4.40±0.88)lines when RGP.And difference statistically significant(t=13.58, P=0.00). Conclusion Wearing could...
Abstract Background Owing to the crucial role endometrium plays in embryo implantation, four main endometrial preparation protocols have become important factors study of pregnancy outcomes FET cycles. Previous studies shown that best these remains controversial for women undergoing FET. Methods A total 10333 cycles from January 2018 December were analyzed this study. They categorized into groups according regimen: natural (Group NC,n = 815), hormone replacement therapy HRT ,n 6434), GnRH...