A5053566791- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Atrial Fibrillation Management and Outcomes
- Immunotherapy and Immune Responses
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- Immune cells in cancer
- Diabetes Management and Research
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- Diabetes Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Pharmaceutical Economics and Policy
- Prosthetics and Rehabilitation Robotics
- Glycosylation and Glycoproteins Research
- Plant Pathogens and Fungal Diseases
- Immune Response and Inflammation
- Plant Disease Resistance and Genetics
- IL-33, ST2, and ILC Pathways
- Fungal Plant Pathogen Control
- Demographic Trends and Gender Preferences
- Diabetes Management and Education
- Cystic Fibrosis Research Advances
Brown University
2022-2025
Royal Adelaide Hospital
2024
South Australia Pathology
2024
Medtronic (United States)
2023-2024
Northwestern University
2024
CSL (Australia)
2021
Rutgers, The State University of New Jersey
1993-2015
Rutgers Health
2014
Northern Illinois University
2014
Johnson University
1991-2013
Mesenchymal stem cells (MSCs) have been employed successfully to treat various immune disorders in animal models and clinical settings. Our previous studies shown that MSCs can become highly immunosuppressive upon stimulation by inflammatory cytokines, an effect exerted through the concerted action of chemokines nitric oxide (NO). Here, we show also enhance responses. This immune-promoting occurred when proinflammatory cytokines were inadequate elicit sufficient NO production. When inducible...
Mammalian mesenchymal stem cells (MSCs) have been shown to be strongly immunosuppressive in both animal disease models and human clinical trials. We reported that the key molecule mediating immunosuppression by MSCs is species dependent: indoleamine 2,3-dioxygenase (IDO) inducible nitric oxide synthase (iNOS) mouse. In present study, we isolated from several mammalian species, each of a different genus, investigated involvement IDO iNOS during MSC-mediated immunosuppression. The...
Mesenchymal stem cells (MSCs) are believed to exert their regenerative effects through differentiation and modulation of inflammatory responses. However, the relationship between severity inflammation cell-mediated tissue repair has not been formally investigated. In this study, we applied different concentrations dexamethasone (Dex) anti-CD3-activated splenocyte cultured with or without MSCs. As expected, Dex exhibited a classical dose-dependent inhibition T-cell proliferation....
The poor efficacy of the in vivo anti-tumor immune response has been partially attributed to ineffective T-cell responses mounted against tumor. Fas-FasL-dependent activation-induced cell death (AICD) T cells is believed be a major contributor compromised immunity. molecular mechanisms AICD are well-investigated, yet possibility regulating for cancer therapy remains explored. In this study, we show that histone deacetylase inhibitors (HDACIs) can inhibit apoptosis CD4+ within tumor, thereby...
The colon cancer cell line, HT29, produces a soluble substance (HT29 factor) that blocks mitogen-induced T proliferation and the production of interleukin 2 (IL 2). Inhibition by HT29 factor is reversible not due to decline in viability or an alteration kinetics proliferation. It occurs even when added only 24 hr before terminating cultures, indicating affects division after activation cells has already occurred. No inhibitory activity was found medium conditioned human colonic epithelial...
Background: This trial compared the long-term safety and efficacy of basal insulin preparations, detemir NPH insulin, in basal-bolus therapy for patients with type 1 diabetes. Methods: multinational open, parallel-group randomized to receive or twice daily addition mealtime human soluble insulin. Doses were titrated towards predefined glycemic targets. After an initial 6-month treatment period, invited participate a extension period. A total 289 from 421 elected continue trial, which 252...
Current estimates of atrial fibrillation (AF)-associated mortality rely on claims- or clinical-derived diagnoses AF, limit AF to a binary entity, are confounded by comorbidities. The objective the present study is assess association between device-recognized and among patients with cardiac implantable electronic devices capable sensitive continuous arrhythmia detection. Secondary outcomes include relative cohorts no paroxysmal persistent permanent AF. Using deidentified Optum Clinformatics...
Abstract Introduction Medicare beneficiaries face significant health risks and care disruptions during public emergencies, but little is known about how patterns evolved throughout the COVID-19 pandemic or differed between traditional (TM) Advantage (MA). Methods Using claims data for over 20 million hospital discharges 2018-2022, we examined trends in length of stay, discharge disposition, mortality among with five major comorbidities (dementia, diabetes, congestive heart failure, hip...
SUMMARY Human intestinal intraepithelial lymphocytes (IEL) demonstrate target cell-restricted spontaneous cytotoxic (SC) activity that is due to CD2+CD3+CD8+CD16−CD56– effector eells: they kill epithelial cell (EC) tumours (such as DLD-1 colon cancer eells), but not natural killer (NK)-sensitive K-562 cells. The present study shows the measured levels of SC activities by IEL correlated with those autologous lamina propria (LPL), peripheral blood (PBL). Also, susceptibilities clones lysis and...
Apple scab, caused by Venturia inaequalis, is one of the most damaging diseases worldwide on apple and currently managed mainly scheduled applications fungicides. Understanding pathogen population structure important for breeding deployment resistant cultivars. Isolates V. inaequalis were sampled from a number cultivars in China, India, United Kingdom to estimate differences populations. Amplified fragment length polymorphism (AFLP) markers used genotype isolates, mostly China Kingdom. The...
Abstract Aims Assessment of the long‐term safety and efficacy liquid inhaled insulin via AERx ® Diabetes Management System (iDMS) in a basal/bolus treatment regimen adults with Type 1 diabetes. Methods Patients were randomized 2 : to prandial ( n = 205) or subcutaneous (s.c.) 99) insulin, plus one/two daily injections neutral protamine Hagedorn (NPH) for 12 months. The primary endpoints pulmonary function tests (PFT) baseline changes chest X‐rays at Safety assessments measured regular...
Summary In food poisoning, Staphylococcus aureus secretes staphylococcal enterotoxin B (SEB), a superantigen that causes intense T‐cell proliferation and cytotoxicity. The effects of SEB on lytic activity by human intestinal intraepithelial lymphocytes (IEL) were investigated. Jejunal IEL, from morbidly obese individuals undergoing gastric bypass operations, tested for SEB‐induced cytotoxicity against C1R B‐lymphoblastoid cells, HT‐29 adenocarcinoma or CD1d‐transfected cells using the 51...