A5114310140- Circadian rhythm and melatonin
- Genomics, phytochemicals, and oxidative stress
- Diet, Metabolism, and Disease
- Migraine and Headache Studies
- Pancreatic and Hepatic Oncology Research
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- Glutathione Transferases and Polymorphisms
- Sympathectomy and Hyperhidrosis Treatments
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Cancer Cells and Metastasis
- Trigeminal Neuralgia and Treatments
- Orthopaedic implants and arthroplasty
- Flowering Plant Growth and Cultivation
- Neural and Behavioral Psychology Studies
- Orthopedic Infections and Treatments
- Chronic Kidney Disease and Diabetes
- Ferroptosis and cancer prognosis
- Biological Research and Disease Studies
- Connective tissue disorders research
- Pediatric Urology and Nephrology Studies
- Ophthalmology and Eye Disorders
Chinese PLA General Hospital
2023-2025
Nankai University
2023-2024
University of California, San Diego
2023-2024
Moores Cancer Center
2024
PLA Academy of Military Science
2023
Salk Institute for Biological Studies
2023
Anhui Medical University
2023
Nanjing Agricultural University
2020
Abstract Background Migraine stands as a prevalent primary headache disorder, with prior research highlighting the significant involvement of oxidative stress and inflammatory pathways in its pathogenesis chronicity. Existing evidence indicates capacity Dl-3-n-butylphthalide (NBP) to mitigate inflammation, thereby conferring neuroprotective benefits many central nervous system diseases. However, specific therapeutic implications NBP context migraine remain be elucidated. Methods We...
Chronic migraine (CM) patients with medication overuse headache (MOH) exhibit distinct neurobiological alterations compared to those without MOH. However, prior studies, often limited single imaging modalities, have yielded inconsistent findings. This study employs multimodal MRI—combining structural, diffusion tensor, and functional imaging—to characterize brain abnormalities in CM MOH, while investigating the relationship between acute analgesic use frequency these changes. The employed...
Clinical observations have shown that transcutaneous occipital nerve stimulation (tONS) is effective in treating migraine. However, the underlying mechanisms are poorly understood. This study employs a rodent model to investigate therapeutic effects of tONS on migraine-related pain and explore potential mechanisms. The SD rats were used establish migraine by repeated epidural infusions inflammatory soup (IS). Modified bilateral electrodes attached noninvasively for treatments. Periorbital...
Sleep deprivation can trigger acute headache attacks in individuals with migraine; however, the underlying mechanism remains poorly understood. The aim of this study was to investigate effects sleep (ASD) on brain function migraine without aura (MWoA) via functional magnetic resonance imaging (fMRI). Twenty three MWoA and 23 healthy controls (HCs) were fairly included study. All participants underwent two MRI scans: one at baseline (prior deprivation) another following 24 h ASD. Images...
The study assessed the association between migraine and cardiovascular disease (CVD) mortality in US population.Previous studies have drawn different conclusions about CVD based on populations; therefore, it is important to explore relationship population.This prospective cohort included 10,644 participants from National Health Nutrition Examination Survey (NHANES) 1999-2004. Participants who reported having severe headache or were classified as migraine. Mortality data obtained by linkage...
Central composite design (CCD), utilized with three independent variables, verified that the optimal treatment conditions in bitter melon fruit were melatonin (MT) concentration of 120 µmol L−1, ethanol 6%, and immersing time 10 min. Under conditions, experimental values firmness, chilling injury (CI) index, weight loss shown as 27.81 N, 65.625%, 0.815%, respectively. Moreover, combined effect MT on CI physiological quality postharvest stored at 4 °C was investigated. It found contributed to...
The chemical carcinogen diethylnitrosamine (DEN) is often used to induce HCC in mice. Curiously, several labs have reported that the removal of oncoproteins from hepatocytes exacerbated DEN-induced HCC, with mechanisms unknown. This study aimed at deciphering molecular underlying tumor suppressive effect oncoproteins.
Migraine has been demonstrated to exhibit abnormal functional connectivity of large-scale brain networks, which is closely associated with its pathophysiology and not yet explored by edge connectivity. We used an edge-centric approach combined motif analysis evaluate higher-order communication patterns networks in migraine.
The use of patient-derived organoids (PDOs) to characterize therapeutic sensitivity and resistance is a promising precision medicine approach, its potential inform clinical decisions now being tested in several large multiinstitutional trials. PDOs are cultivated the extracellular matrix from basement membrane extracts (BMEs) that most commonly acquired commercially. Each site utilizes distinct BME lots may be restricted due availability commercial sources. However, effect different sources...
Patients with migraine often experience not only headache pain but also cognitive dysfunction, particularly in attention, which is frequently overlooked both diagnosis and treatment. The influence of these attentional deficits on the pain-related clinical characteristics remains poorly understood, clarifying this relationship could improve care strategies.
The use of patient-derived organoids (PDOs) to characterize therapeutic sensitivity and resistance (pharmacotyping) is a promising precision medicine approach. potential this approach inform clinical decisions now being tested in several large multi-institutional trials. PDOs are cultivated extracellular matrix from basement membrane extracts (BMEs) that most commonly acquired commercially. Each site utilizes distinct BME lots may be restricted due the availability commercial sources....
Abstract Migraine exhibits a substantial prevalence worldwide. The current diagnostic criteria rests exclusively on clinical characteristics without any objective and reliable means. calcitonin gene‐related peptide (CGRP), as biomarker for distinguishing migraine, undergoes swift degradation, featuring half‐life of under 10 min, which poses significant challenge to the point‐of‐care testing CGRP in application. Here, photonic crystal (PC)‐based biochip has been developed detect via...
Background The clinical profile of cluster headache may differ among different regions the world, warranting interest in data obtained from initial Chinese Cluster Headache Register Individual Study (CHRIS) for better understanding. Methods We conducted a multicenter, prospective, longitudinal cohort study on across all 31 provinces China, aiming to gather characteristics, treatment approaches, imaging, electrophysiological and biological samples. Results In total 816 patients were enrolled...
Abstract Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related death without effective treatment. Oncogenic drivers, including PTPN11/Shp2, Ikkβ kinase (IKK), c-Met and β-catenin, as well tumor microenvironment illustrated by a carcinogen or diethylnitrosamine (DEN)-treated models, have combined contribution to cancer progression that distinct prevalence in human HCC progression. We previously found disruption Ras/Erk Shp2 deletion with NF-κB unexpectedly...
Abstract The 5-year survival rate for pancreatic ductal adenocarcinoma (PDAC) is only 10%. PDAC projected to soon become the second leading cause of cancer death. Tobacco one main risk factors PDAC. Incidence increases 2-fold among tobacco users, and 20-35% cases are attributed smoking. However, specific pathways activated by carcinogens remain elusive.This research project addresses impact in etiology. We hypothesize that increase reactive oxygen species (ROS), which elevates Nrf2 redox...
Abstract Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy with five-year survival rate of less than 11%, making it one the deadliest cancers. Notably, 95% PDA cases exhibit KRAS mutations, contributing to dysregulated cell signaling networks. Despite extensive research into interplay various oncogenic pathways in pancreatic tumorigenesis, targeted therapies against these networks have displayed modest efficacy, most patients rapidly developing therapeutic resistance....
<title>Abstract</title> Background: Migraine stands as a prevalent primary headache disorder, with prior research highlighting the significant involvement of oxidative stress and inflammatory pathways in its pathogenesis chronicity. Existing evidence indicates capacity Dl-3-n-butylphthalide (NBP) to mitigate inflammation, thereby conferring neuroprotective benefits many central nervous system diseases. However, specific therapeutic implications NBP context migraine remain be elucidated....
<div>Abstract<p>The Ras/Erk and NF-κB pathways play critical roles in cell proliferation are known to drive oncogenesis when overactivated. Herein we report a gatekeeper function of the two by working synergy suppress liver tumorigenesis. Hepatocyte-specific deletion both Shp2/Ptpn11 Ikkβ mice, which promote signaling, respectively, exacerbated chemical carcinogenesis even triggered spontaneous development hepatocellular carcinoma (HCC). We show that unanticipated severe tumor...
SupplementaryFigure from Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation Hepatocarcinogenesis
Supplementary Data from Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation Hepatocarcinogenesis
Supplementary Data from Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation Hepatocarcinogenesis
Supplementary Data from Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation Hepatocarcinogenesis